Navigation Links
Research Indicates Geron's Human Embryonic Stem Cell-Based,Therapeutic for Spinal Cord Injury Evades Direct Attack by the,Human Immune System

MENLO PARK, Calif.--(BUSINESS WIRE)--Jun 11, 2007 - Geron Corporation (Nasdaq:GERN) today announced the presentation of research studies indicating that GRNOPC1, the company's human embryonic stem cell (hESC)-based therapeutic for the treatment of spinal cord injury, evades a direct attack by the human immune system.

Presented by Geron scientist Ross Okamura at the Federation of Clinical Immunology Societies meeting in San Diego, the findings could mean that patients treated with GRNOPC1 would require significantly lower doses and/or shorter courses of immunosuppression than what are required for patients who undergo solid organ transplants.

"The results imply that our cell-based therapeutic, unlike traditional solid organ transplants, is minimally recognized by the human immune system," said Thomas B. Okarma, Ph.D, M.D., Geron's president and chief executive officer. "Because GRNOPC1 cells are allogenic, it was expected that they would be recognized and destroyed by multiple immune rejection modulators. This isn't the case. The benefit to patients is that a reduction in the requirement for immunosuppression decreases the potential for untoward side effects that are common with those types of drugs."

The data indicate that GRNOPC1 cells have low susceptibility to both direct cell and antibody-mediated immune responses. The data also show that GRNOPC1 cells do not widely express non-human antigens, such as Neu5GC, that might have originated from mouse feeder cells to which the original hESC cell line was exposed in its initial derivation. Expression of such non-human antigens would typically lead to lysis by antibodies present in the sera of normal individuals.

In the studies, GRNOPC1 cells were tested for susceptibility to both immune effector cells and sera from normal healthy individuals. GRNOPC1 cells stimulated very low levels of T cell proliferation. Allogenic T cell proliferation is a
'"/>




Page: 1 2 3

Related medicine technology :

1. NIEHS Researchers Identify Enzyme Critical in DNA Replication
2. Stanford Researchers Find Brain Pathway of Depression in Rats
3. Suven Life Sciences Presenting Pre-clinical data of their NCE’s SUVN-502 and SUVN-507at International Brain Research Organization (IBRO) 2007 World Congress of Neuroscience
4. From Clinical Cancer Research: Rethinking Therapeutic Cancer Vaccine Trials
5. Researchers Discover Method for Identifying How Cancer Evades the Immune System
6. Infertile Voice Supports Stem Cell Research: RESOLVE Calls for Patient Options in Using Frozen Embryos
7. Fact Sheet: Advancing Stem Cell Research While Respecting Moral Boundaries
8. President Bush Ignores Americas Plea for Support of Stem Cell Research
9. Researchers Discover Gene For Rare Skin Disorder
10. The Christopher and Dana Reeve Foundation Expresses Disappointment Over President Bushs Veto of the Stem Cell Research Enhancement Act
11. Research on New Treatment for Neglected Disease Published in The New England Journal of Medicine
Post Your Comments:
(Date:8/28/2015)... 28, 2015 , Joint research by ... from Biostar , Published in ,Stem Cells Translational ... lifespan through multiple IV administration of Adipose-derived MSC ... expectancy found , Commercialization within 5 years expected ... possibility that adult mesenchymal stem cells (MSCs) may extend ...
(Date:8/28/2015)... SAN FRANCISCO , August 28, 2015 ... is expected to reach USD 49.12 billion by 2020, ... 2020, according to a new report by Grand View ... an estimated CAGR of 49.7% from 2014 to 2020. ... Growing aging population along with rising incidences of ...
(Date:8/27/2015)... Aug. 27, 2015 Biosimilars are not ... the U.S. Food and Drug Administration (FDA) for ... in its draft guidance issued today. The FDA,s ... proposes distinguishable names, calling for biological products to ... suffix. This proposal reflects the agency,s thinking that ...
Breaking Medicine Technology:Korean Researchers Find the Possibility that Adult Mesenchymal Stem Cells (MSCs) May Extend Lifespan 2mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 2mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 3mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 4mHealth Market is Expected to Reach $49.12 Billion By 2020: Grand View Research, Inc. 5Biologics Prescribers Collaborative (BPC) Statement on FDA Draft Guidance entitled "Nonproprietary Naming of Biological Products" 2
... Lytle LLP, one of the region,s best known law ... Court in Rochester, upheld a high-profile products liability verdict ... In its decision, the Fourth Department judicial panel found ... of Cheektowaga, NY a quadriplegic.  In making its findings, ...
... 18, 2011 The U.S. Food and Drug Administration ... (neovascular) age-related macular degeneration (AMD), a leading cause of ... older. (Logo: http://photos.prnewswire.com/prnh/20090824/FDALOGO ) ... affects the macula, the part of the eye that ...
Cached Medicine Technology:The Appellate Division of State Supreme Court has Upheld a Landmark 2010 Products Liability Verdict Which Found Cybex International Responsible for Catastrophic Injuries Suffered by a Cheektowaga Woman 2The Appellate Division of State Supreme Court has Upheld a Landmark 2010 Products Liability Verdict Which Found Cybex International Responsible for Catastrophic Injuries Suffered by a Cheektowaga Woman 3FDA Approves Eylea for Eye Disorder in Older People 2
(Date:8/28/2015)... ... August 28, 2015 , ... Dr. Gregory K. Toumayan, D.C., Q.M.E., is ... in shoulder pain, hip pain, neck pain, stiffness, muscle spasms, and numbness. ... University of Illinois, and then went on to earn his title of Doctor of ...
(Date:8/28/2015)... Newton, Mass. (PRWEB) , ... August 28, 2015 ... ... is proud to announce its collaboration with coffee connoisseur and Emmy-nominated actress, Sofia ... Bar™ brewer. It features revolutionary Thermal Flavor Extraction™ technology, which delivers a variety ...
(Date:8/28/2015)... ... August 28, 2015 , ... United Benefit Advisors (UBA), the ... Group as its newest Partner Firm. Founded in 1924 and headquartered in Pittsburgh, ... on their goals. Within the past 10 years, TJS Insurance Group has emerged ...
(Date:8/28/2015)... ... August 28, 2015 , ... A complimentary webinar offered by healthcare consulting ... Services’ (CMS) proposal to mandate bundled payments through the Comprehensive Care for ... Game Day: Comprehensive Care for Joint Replacement,” takes place at 12 noon EDT on ...
(Date:8/28/2015)... ... , ... Santa Rosa was recently recognized, for the fourth consecutive year, as ... KLAS “2015 Midterm Performance Review: Software & Services”, Santa Rosa achieved the highest rating ... and KLAS are directly related to our company culture.” said Richard Helppie, chairman and ...
Breaking Medicine News(10 mins):Health News:Healthpointe Welcomes Dr. Gregory K. Toumayan, Chiropractor, to Colton, Temecula, and Perris 2Health News:Healthpointe Welcomes Dr. Gregory K. Toumayan, Chiropractor, to Colton, Temecula, and Perris 3Health News:Sofia Vergara Partners With SharkNinja® To Launch The Ninja Coffee Bar™ 2Health News:Sofia Vergara Partners With SharkNinja® To Launch The Ninja Coffee Bar™ 3Health News:TJS Insurance Group Is Latest Partner Firm To Join United Benefit Advisors 2Health News:TJS Insurance Group Is Latest Partner Firm To Join United Benefit Advisors 3Health News:PYA Offers Complimentary CCJR Webina — Game On 2Health News:PYA Offers Complimentary CCJR Webina — Game On 3Health News:Santa Rosa Consulting Recognized by Modern Healthcare as One of the Top 100 Best Places to Work and from KLAS Research with the Highest Rating for Go-Live Support 2
... (April 26, 2010, 4 p.m. EDT) Myelodysplastic syndromes (MDS) ... five times more common in seniors than previously thought, according ... Cancer Center at Hackensack University Medical Center. The study ... at much higher risk for heart attack, diabetes and other ...
... development of screening tests for early detection , MONDAY, April ... of ovarian cancer may lead to the development of a ... In the study, scientists uncovered early tumors and precancerous lesions ... surface. , "This is the first study giving very strong ...
... ... , ... -- Few of us, by the age of 25, have a life story complete and ... born author, Nathalia Zongo, who lived a childhood of crisis, hardship and deliverance in a ...
... believe , MONDAY, April 26 (HealthDay News) -- Two kinds ... the risk of heart disease and high blood pressure by ... , In a new study, researchers report that the findings ... when it comes to protecting the body from high blood ...
... study finds , MONDAY, April 26 (HealthDay News) -- ... new study finds that people battling depression reach for ... , Many people believe that "when they are feeling ... said lead researcher Dr. Beatrice A. Golomb, an associate ...
... or diabetes now widespread, CDC survey finds , MONDAY, ... American adults have either high blood pressure, high cholesterol ... disease, stroke and other cardiovascular problems, a new government ... National Health and Nutrition Examination Survey (NHANES) 1999-2006 shows ...
Cached Medicine News:Health News:MDS, a blood cancer, strikes nearly 5 times more Americans than previously thought 2Health News:MDS, a blood cancer, strikes nearly 5 times more Americans than previously thought 3Health News:Study Makes Strides in Understanding Ovarian Cancer 2Health News:Autobiography Gives Child's Eye View of West African Regime Change and Family Fallout 2Health News:Autobiography Gives Child's Eye View of West African Regime Change and Family Fallout 3Health News:Autobiography Gives Child's Eye View of West African Regime Change and Family Fallout 4Health News:Chocolate a Sweet Pick-Me-Up for the Depressed 2Health News:Chocolate a Sweet Pick-Me-Up for the Depressed 3Health News:Nearly Half of U.S. Adults Have Heart Risk Factors 2Health News:Nearly Half of U.S. Adults Have Heart Risk Factors 3
Two prong stainless steel tips; with titanium handle/...
Straight shaft with fine pointed 0.3mm Tips for Grasping Delicate Capsule; In Titanium....
12mm from bend to 0.12mm 1x2 teeth; In Titanium....
Straight Shafts with 0.12mm 1X2 Teeth With 5mm Tying Platform; In Titanium...
Medicine Products: