Research Documents Scalable Production, Survival Following,Engraftment and Positive Impact on Cardiac Function in Infarcted,Rats for Geron's Human Embryonic Stem Cell-Based Therapeutic for,Heart Failure
MENLO PARK, Calif.--(BUSINESS WIRE)--Jun 19, 2007 - Geron
Corporation (Nasdaq: GERN) today reported that research documenting
the scalable production, survival following engraftment and
positive impact on cardiac function in infarcted rats was presented
today for GRNCM1, the company's human embryonic stem cell
(hESC)-based therapeutic for heart failure, at the International
Society for Stem Cell Research (ISSCR) Annual Meeting in Cairns,
The presentation was one of seven involving Geron scientists and
collaborators that documented the company's progress in developing
multiple therapeutic products from its hESC platform. Other
presentations focused on the gene expression and neurotrophic
protein secretion patterns of hESC-derived oligodendroglial
progenitor cells for acute spinal cord injury, the functional
characterization of hESC-derived islets for diabetes, and
hESC-derived chondrocytes for arthritis and other orthopedic
"We have made significant progress in the development of
hESC-based therapeutics," said Thomas B. Okarma, Ph.D., M.D.,
Geron's president and chief executive officer. "GRNCM1 will be the
second product we intend to develop clinically. Large animal proof
of concept studies are imminent. With our most advanced cell type,
GRNOPC1 for acute spinal cord injury, we remain on track for the
filing of an Investigational New Drug (IND) Application with the
U.S. Food and Drug Administration later this year pending the
outcome of our ongoing safety studies. Lastly, we recently
published our scalable method to produce GRNIC1, hESC-derived
islets for diabetes. We presented data at the ISSCR Annual Meeting
on a procedure to enhance the insulin-secreting potency of the
cells that are currently in animal studies in our collaborator's
laboratories at the University of Alberta. Geron remains at the
forefront of taking embryonic stem cell-derived products into
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