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Research Documents Scalable Production, Survival Following,Engraftment and Positive Impact on Cardiac Function in Infarcted,Rats for Geron's Human Embryonic Stem Cell-Based Therapeutic for,Heart Failure

MENLO PARK, Calif.--(BUSINESS WIRE)--Jun 19, 2007 - Geron Corporation (Nasdaq: GERN) today reported that research documenting the scalable production, survival following engraftment and positive impact on cardiac function in infarcted rats was presented today for GRNCM1, the company's human embryonic stem cell (hESC)-based therapeutic for heart failure, at the International Society for Stem Cell Research (ISSCR) Annual Meeting in Cairns, Australia.

The presentation was one of seven involving Geron scientists and collaborators that documented the company's progress in developing multiple therapeutic products from its hESC platform. Other presentations focused on the gene expression and neurotrophic protein secretion patterns of hESC-derived oligodendroglial progenitor cells for acute spinal cord injury, the functional characterization of hESC-derived islets for diabetes, and hESC-derived chondrocytes for arthritis and other orthopedic applications.

"We have made significant progress in the development of hESC-based therapeutics," said Thomas B. Okarma, Ph.D., M.D., Geron's president and chief executive officer. "GRNCM1 will be the second product we intend to develop clinically. Large animal proof of concept studies are imminent. With our most advanced cell type, GRNOPC1 for acute spinal cord injury, we remain on track for the filing of an Investigational New Drug (IND) Application with the U.S. Food and Drug Administration later this year pending the outcome of our ongoing safety studies. Lastly, we recently published our scalable method to produce GRNIC1, hESC-derived islets for diabetes. We presented data at the ISSCR Annual Meeting on a procedure to enhance the insulin-secreting potency of the cells that are currently in animal studies in our collaborator's laboratories at the University of Alberta. Geron remains at the forefront of taking embryonic stem cell-derived products into clinical development."


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