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Repeated Radioimmunotherapy With 131I-Labetuzumab Appears Safe and,Effective in Colorectal Cancer with Liver Metastases

anti-CEA antibody at repeated doses of 40 - 50 mCi/m2," he commented further.

In an early study, the German scientists reported a 5-year survival rate of 51.3% in 19 colorectal cancer patients who received a single dose of 131I- labetuzumab after surgery versus 7% of control patients who did not receive the antibody therapy, but only conventional therapies. Median overall survival from the first surgery was 68.0 months for the treatment group compared to 31 months for the control group. Results of this study were published in the September 20, 2005, issue of the Journal of Clinical Oncology.

About Colorectal Cancer

According to the American Cancer Society, about 153,760 Americans will be diagnosed with colorectal cancer in 2007. An estimated 52,180 people will die from the malignancy this year. The liver is the most common site of distant metastasis, affecting up to 60% of patients, and is the only metastatic site in 30% of patients. The 5-year survival rate for colorectal cancer patients with unresected liver metastases is close to 0%. With complete resection of liver metastases, a 5-year survival rate of 25% to 37% can be achieved. However, despite postsurgical adjuvant systematic or intrahepatic chemotherapy, cancer relapse occurs in approximately two thirds of resected patients, with more than one half first experiencing recurrence in the liver. Currently there is no established adjuvant therapy for the treatment of colorectal cancer patients after resection of liver metastases.

About Immunomedics

Immunomedics is a New Jersey-based biopharmaceutical company focused on the development of monoclonal, antibody-based products for the targeted treatment of cancer, autoimmune and other serious diseases. We have developed a number of advanced proprietary technologies that allow us to create humanized antibodies that can be used either alone in unlabeled or "naked" form, or conjugated with radioactive isotopes, chemotherapeutics or tox
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