Navigation Links
Repeated Radioimmunotherapy With 131I-Labetuzumab Appears Safe and,Effective in Colorectal Cancer with Liver Metastases

- Initial Phase II Study Results Presented at Society of Nuclear Medicine Annual Meeting -

WASHINGTON, June 04, 2007 /PRNewswire-FirstCall/ -- Immunomedics, Inc. , a biopharmaceutical company focused on developing monoclonal antibodies to treat cancer and other serious diseases, today announced that its anti-carcinoembryonic antigen (CEA) antibody, labetuzumab, labeled with the radioisotope, iodine-131, was found to be safe and active when given in two doses to patients with colorectal cancer that has metastasized to the liver. Dr. Johannes Meller of the University of Gottingen, Germany, reported results from this study in an oral presentation at the 54th Annual Meeting of the Society of Nuclear Medicine (SNM) in Washington, DC.

Forty colorectal cancer patients with liver metastases have been enrolled in this Phase-II study. After surgery to remove liver metastases, patients were screened for cancer by PET and CT scans. At the time of reporting, 32 patients were evaluated. Sixteen were found to be negative for cancer (the adjuvant group) after surgery while the other 16 patients were found to have evidence of recurrent disease (the non-adjuvant group).

Six weeks after liver surgery, both groups of patients received an initial dose of 40 - 50 mCi/m2 of 131I-labetuzumab, followed by a second infusion three months later. At the time of reporting, 62.5% of patients (10/16) in the adjuvant group remained disease-free. For the non-adjuvant group, 25% of patients (4/16) reported no cancer relapse.

"These initial results suggested that re-treatment with 131I-labetuzumab is safe, feasible and well accepted, with transient myelosuppression the principal and only adverse effect," commented Dr. Johannes Meller, Director of Nuclear Medicine, University of Gottingen, Germany, and lead author of the study presented. "In 2008, we plan to initiate a multicenter, randomized trial evaluating the radiolabeled
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Fractionated Radioimmunotherapy With (90)Y-epratuzumab in Non-Hodgkins Lymphoma Appears Safe and Active in a Phase I/II Study
2. Two Abbott Studies Reaffirm Carotid Artery Stenting as a Safe and Effective Treatment to Reduce Risk of Stroke
3. Merck at ASCO 2007: Spectrum of Studies Reinforces Promise of Erbitux for Colorectal and Head and Neck Cancer Patients
4. Merck at ASCO 2007: New Data Demonstrate the Value of UFT as an Important Treatment Option for Patients With Metastatic Colorectal Cancer
5. Eloxatin (oxaliplatin injection)-Based Chemotherapy Sets New Treatment Benchmark in Patients With Metastatic Colorectal Cancer
6. The Eloxatin-Based Regimen (FOLFOX4) Significantly Improved Progression Free Survival When Given Before and After Surgery in Patients With Resectable Liver Metastases From Colorectal Cancer
7. Poniard Pharmaceuticals Announces Promising Data From Interim Safety Analysis of Phase 1 Combination Trials of Picoplatin in Colorectal and Prostate Cancers
8. Positive Final Data from HyCAMP Phase II Trial in Metastatic Colorectal
9. Final Vectibix Positive Pivotal Phase 3 Trial Results In Metastatic Colorectal Cancer Patients Published
10. Randomized Phase III Trial Showed Erbitux Significantly Improved Secondary Endpoints of Progression-Free Survival and Disease Control in Metastatic Colorectal Cancer Patients
11. Breast Cancer and HER-2/neu: Diagnostic Tools for Targeted Therapy
Post Your Comments:
(Date:5/17/2013)... May 17, 2013  Sorrento Therapeutics, Inc. (OTCBB: ... Advanced Technology Small Business Technology Transfer Research (STTR) ... and Infectious Diseases (NIAID), a division of the ... of novel human antibody therapeutics to combat ... Staph) infections, including methicillin-resistant S. aureus ...
(Date:5/17/2013)... and CAMBRIDGE, Mass., May 17, 2013   ... a purchaser of Aveo Pharmaceutical, Inc. (NASDAQGS: AVEO) securities ... for the District of Massachusetts . ... officers violated the Securities Exchange Act of 1934 (the ... 2013 (the "Class Period"). (Logo: http://photos.prnewswire.com/prnh/20130103/MM36754LOGO ...
(Date:5/17/2013)... -- United Medical Education, a company that provides online ... Life Support (PALS) and Basic Life Support (BLS), is ... course manuals. In order to gain access to ... account with the company. By offering the free learning ... is setting a precedent among similar companies. ...
Breaking Medicine Technology:Sorrento Therapeutics, Inc. announces its approach to developing human antibody therapeutics against MRSA receives continued support from the National Institute of Allergy and Infectious Diseases 2Sorrento Therapeutics, Inc. announces its approach to developing human antibody therapeutics against MRSA receives continued support from the National Institute of Allergy and Infectious Diseases 3Sorrento Therapeutics, Inc. announces its approach to developing human antibody therapeutics against MRSA receives continued support from the National Institute of Allergy and Infectious Diseases 4Aveo Pharmaceuticals, Inc. Sued by Investor 2Aveo Pharmaceuticals, Inc. Sued by Investor 3ACLS Online Course Manuals are Now Available at No Cost through United Medical Education 2
(Date:5/18/2013)... Florida (PRWEB) May 18, 2013 Adolescents, ... also known as “Spice” or “K2” are landing in ... helping to curb this drug epidemic with a ... synthetic marijuana. , According to research from the National ... second-most popular illegal drug among American teenagers. In 2012, ...
(Date:5/18/2013)... May 18, 2013 The Ayurvedic practitioner ... education institution in the West. Program is available in ... Ayurveda is a healing modality practiced for over 5,000 ... is considered that health begins when an individual lives ... of their individual needs. Ayurveda aims to heal an ...
(Date:5/18/2013)... (PRWEB) May 18, 2013 Rio Salon ... recently completed a stylish renovation that features tranquil, Eastern ... , From the ground up, this Morro Bay ... fresh flooring, soothing colors and comfortable spa beds. Additional ... including an Apilus epilator machine. The shampoo area ...
(Date:5/18/2013)... (PRWEB) May 18, 2013 Losing weight remains ... But among the horde of new weight loss products available ... talked about. Recent studies about this newest weight loss supplement ... ideal body shape. , Garcinia Cambogia is a sub-tropical fruit ... tamarind. Eating the fruit can suppress a person’s appetite, while ...
(Date:5/18/2013)... Spectrum Surgical Instruments will attend ... in Austin, TX where thousands of GI nursing ... opportunities. , Spectrum Surgical/STERIS will feature its ... capabilities and certified pre-owned equipment. Attendees will ... proper instrument care of flexible endoscopes. , ...
Breaking Medicine News(10 mins):Health News:Spice Addiction Treatment and Synthetic Marijuana Drug Rehab Announced by Recovery Associates 2Health News:Ayurveda Training in Mexico Offered by Escuela de Ayurveda de California, a Leading Institution in the West 2Health News:Rio Salon and Spa, a Beauty Salon in Morro Bay, Undergoes Makeover 2Health News:Lose Weight Without Dieting or Exercising with Garcinia Cambogia Select Now Available At HealthCareSupplementz.com 2Health News:Spectrum Surgical Attends Society of Gastroenterology Nurses and Associates' (SGNA) 40th Annual Conference in Austin, TX 2
... revolutionary weapon for the war against the bulges and fat ... a fat blocker is the first FDA approved diet drug ... ,The prescription diet drug Xenical has been introduced to drugstore ... Friday in a reincarnated form dubbed Alli. It has been ...
... Colorado Springs community of U.S is waiting with bated breath. ... person has contracted TB from a young nurse who ... tuberculosis has been found responsible for the untimely death of ... University (CSU) at Pueblo. , According to Dr. Ned ...
... spends more waking time thinking about sex than ... measure once the lights are out. ,According to ... canadian research team report that about 8 per cent of ... sexual-related activity. ,Professor Antonio Zadra from the University of ...
... for Allergy & Immunology (LIAI) made an important finding, ... for treating autoimmune and inflammatory diseases such as ... studies, conducted in laboratory mice, demonstrated the role of ... broken down in the body, in regulating inflammation. ...
... (OIC) who met at Kuala Lumpur were addressed on the ... public health services of most of the 56 member nations ... the 10 nations with the highest rate of infant mortality ... speaking at an inaugural meeting of various OIC health ministers, ...
... check-ups of workers dismantling Norwegian cruise liner "Blue Lady", ... a shipbreaking yard in Gujarat. ,During ... of Occupational,Health will also impart training to the workers ... protective masks. ,"Earlier, there were no such ...
Cached Medicine News:Health News:Alli- a New Weapon for War Against the Bulges 2Health News:Fears Of Spread Of TB After Students Death 2Health News:Equality Among Genders in Terms of Sex Dreams 2Health News:New Therapeutic Approach for Autoimmune and Inflammatory Diseases 2Health News:Muslim Nations Urged To Address Health Needs 2Health News:Health Checks on Workers Dismantling Blue Lady in Gujarat 2
CPTMeister is a coding reference based on the Physicians' Current Procedural Terminology (CPT) codes developed by the American Medical Association. It is an iSilo document composed of more than 2,000...
The BluefishRx ICD-9 is a Palm OS code lookup tool which incorporates the ICD-9 code set with the full and short code descriptions. It includes a multi keyword search tool with a dictionary of over 2...
MD Coder v 6.0 is a charge capture for the Palm OS and Pocket PC operating systems. We have integrated the feedback from hospitals and physicians. MD Coder v 6.0 comes in three versions: Physician Ba...
Preferred Health Resourses Practice Management System is called Remedy. The PDA version is Remedy for the Palm. It is a data capture program for your medical billing....
Medicine Products: