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Reata's Synthetic Triterpenoids Profiled in Nature Reviews Cancer

IRVING, Texas--(BUSINESS WIRE)--Apr 25, 2007 - Reata Pharmaceuticals, Inc. today announced the publication of a review article covering the company's Synthetic Triterpenoid programs in the May 2007 issue of the prestigious journal "Nature Reviews Cancer."

The article, "Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer," by researchers and Reata scientific collaborators from the Dartmouth Medical School Karen T. Liby, Mark M. Yore and Michael B. Sporn, focuses on two new classes of multifunctional drugs that it reports can prevent and treat cancer in experimental animals. One of Reata's lead clinical candidates, from one of the classes the article describes, the Synthetic Triterpenoids, is entering advanced clinical trials for deadly, late-stage cancers.

The article describes the Synthetic Triterpenoids as a new class of non-toxic and highly multifunctional drugs that have applications for the prevention and treatment of not only cancer, but also of many other diseases with an inflammatory component.

"An outstanding body of work is emerging on the Synthetic Triterpenoids from many top academic collaborators," commented Warren Huff, Reata's CEO. "Dr. Sporn and his team have provided an excellent summary of the broad research currently underway on these compounds and the underlying biological pathways they modulate. Reata is delighted to have the opportunity to collaborate with these researchers in taking take these important new drugs forward to provide a clinical benefit for patients with cancer and other diseases."

Reata in-licensed the complete series of Synthetic Triterpenoids from Dartmouth and the University of Texas M.D. Anderson Cancer Center in 2004. RTA 402, the lead agent from this series, has recently begun Phase 2 clinical studies for cancer and anti-inflammatory diseases. An ongoing Phase 1 study in cancer patients has demonstrated
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