Navigation Links
RTA 402 Shown to Protect Animals Against Toxicities of Standard,Cancer Treatments

IRVING, Texas--(BUSINESS WIRE)--Jun 29, 2007 - Reata Pharmaceuticals, Inc. today announced the presentation of new preclinical data showing their lead anti-cancer agent, the Synthetic Triterpenoid RTA 402, is effective at protecting against common toxicities caused by traditional cancer treatments. This data was presented at the annual meeting of the Multinational Association of Supportive Care in Cancer (MASSC) in St Gallen, Switzerland.

Reata scientists and collaborators presented data showing that when RTA 402 is given in combination with radiation therapy to rats bearing human lung cancer tumors, the drug protected non-cancerous tissue from radiation damage while simultaneously enhancing the anti-tumor effect of the radiation treatment. The senior author of this presentation was Dr. Stephen Sonis of the Harvard Medical School, a well-known expert on cancer supportive care. RTA 402 is a novel, orally administered targeted therapy that inhibits the transcriptional activity of NF-kB and STAT3. Correlative studies presented at MASSC confirmed that RTA 402 inhibited NF-kB in both tumor and normal tissue and decreased many circulating inflammatory cytokines in the animals including TNF(alpha), MMP-9, IL-6, IL-8, and VEGF. In related studies, administration of RTA 402 reduced the duration and severity of radiation and chemotherapy-induced oral mucositis in hamster models of the disease and improved survival in animals receiving toxic doses of two common chemotherapy treatments, doxorubicin and oxaliplatin.

Confirmation of these preclinical results in the ongoing clinical trials of RTA 402 would make the drug an important addition to current treatment regimens. Radiation and chemotherapy cause unpleasant and life-threatening side effects in cancer patients. These therapy-related side effects are often dose limiting and cause delays in treatment or a reduction in treatment intensity, hampering the anti-cancer
'"/>




Page: 1 2 3

Related medicine technology :

1. Gabapentin Shown Effective for Fibromyalgia Pain
2. Breaking Multi-Center Study: Masimo SET Pulse Oximetry Technology Shown to Significantly Lower Instances of Severe Retinopathy of Prematurity in Extremely Low Birth Weight Infants
3. CEL-SCIS CEL-1000 Shown to Significantly Enhance Immune Response Against Avian Flu Antigen in Animals
4. Efficacy and Safety Profile of Basileas Alitretinoin for Severe Refractory Chronic Hand Eczema Confirmed by Data Shown at European Dermatology Congress
5. Innovative Cancer Drug MabThera Again Shown To Improve Survival Rates In Patients With Lymphoma
6. RTA 402 Shown to Inhibit STAT3 in Animal Model and Holds Significant Promise for Treating Breast Cancer
7. Accelreon Pharmas ACE-031Shown to Increase Muscle Mass in Preclinical Studies
8. Cethromycin Shown Effective Against Anthrax in Study
9. CEL-SCIs Cel-1000 Shown to Significantly Enhance Immune Response Against Hepatitis B Antigen in Animals
10. Largest Cervical Cancer Vaccine Efficacy Trial Shows Cervarix Provides Excellent Protection Against Lesions Caused by Most Common Cancer-Causing Virus Types
11. Novavax Pandemic Flu Vaccine Provided Protection Against a Lethal Challenge of Live Virus, Pre-Clinical Data Show
Post Your Comments:
(Date:7/31/2015)... July 31, 2015 Quietly, sedately, ... experience, the domestic pharmaceutical industry is strong, with a ... to high international standards. One place where ... in sub-Saharan Africa: Morocco has quietly become the second ... South Africa . Indeed, Moroccan pharma companies have ...
(Date:7/31/2015)... 31, 2015 According to a ... Product (Bioimpedance Analyzers (BIA), Dual-Energy X-ray Absorptiometry (DEXA), Skinfold ... Global Analysis & Forecast to 2019", published by MarketsandMarkets, ... $911.1 Million 2014 and is estimated to grow to ... 9.4% from 2014 to 2019. Browse ...
(Date:7/30/2015)... VIEW, Calif. , July 30, 2015 ... it will release its second quarter 2015 financial results ... 2015.   In conjunction with the release, the Company ... at 5:00 p.m. Eastern Time on ... of the quarter and other business developments. ...
Breaking Medicine Technology:PharmaBoardroom Releases New Morocco Pharmaceuticals Report 2PharmaBoardroom Releases New Morocco Pharmaceuticals Report 3Body Composition Analyzers Market Worth $1,425.7 Million by 2019 2Body Composition Analyzers Market Worth $1,425.7 Million by 2019 3Body Composition Analyzers Market Worth $1,425.7 Million by 2019 4IRIDEX Announces Second Quarter 2015 Conference Call and Release Date 2
(Date:8/1/2015)... Freeport, ME (PRWEB) , ... August 01, 2015 , ... ... “America’s Retail Champions.” , Wilcoxson was given that honor by the National Retail Federation, ... the retail industry. Wilcoxson was one of three Maine business owners to be named ...
(Date:8/1/2015)... ... August 01, 2015 , ... On Tuesday, July 28th, ... who are thought to have been behind the attack on Anthem Inc. which resulted ... zero day exploits, watering hole attacks and spear phishing campaigns. , For ...
(Date:8/1/2015)... ... August 01, 2015 , ... “ reTXT ” was ... the latest and coolest applications on the market for iOS, Android, and Windows. Joe ... with viewers allows users to clarify, edit and delete any message including ones already ...
(Date:7/31/2015)... (PRWEB) , ... July 31, 2015 , ... Ticket Down is a reputable source of ... the MGM Grand Garden Arena. Fans of every genre of music will have an ... 18th, the first day of the festival, the following artists will perform: Sam Smith, ...
(Date:7/31/2015)... ... , ... Super Bowl 50 will emanate from Levi’s Stadium in Santa Clara, CA ... the Super Bowl. In the two weeks that separate the conference championships and the Super ... Super Bowl game will mark the 50th time it has been held and the festivities ...
Breaking Medicine News(10 mins):Health News:Local Retail Advocate Wins National Recognition 2Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 2Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 3Health News:Frenemy at the Gates - Hackers Excel at Leveraging Trust 4Health News:Correct Auto-Correct and Clarify the Unclear with reTXT Messaging App 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 2Health News:Cheap 2015 iHeartRadio Music Festival Tickets in Las Vegas at MGM Grand Garden Arena: Ticket Down Slashes Ticket Prices on the iHeart Radio Music Festival in Vegas 3Health News:Cheap 2016 Super Bowl Tickets at Levi's Stadium: Ticket Down Slashes Ticket Prices on Super Bowl 50 Tickets in Santa Clara, CA at Levi's Stadium 2
... Gordon HealthDay Reporter , TUESDAY, March 15 (HealthDay ... literally. New research shows that people who own dogs ... minimum amount of exercise each week, thanks to their furry ... activity. People who walk their dogs, walk more. They walk ...
... TEMPE, Ariz People with diabetes could be helped by ... by Arizona State University engineers and clinicians at Mayo Clinic ... United States have diabetes. The disease is the fifth leading ... a higher risk for heart disease, blindness, kidney failure, lower ...
... Irvine, Calif., March 15, 2011 A UC Irvine ... Centers for Disease Control and Prevention research program to ... healthcare settings. Dr. Susan Huang medical director ... Center and a UCI Health Policy Research Institute affiliate ...
... report they have shrunk or slowed the growth of ... routinely prescribed for malaria and rheumatoid arthritis. The ... of the journal Genes & Development and ... prompted the opening of a small clinical trial in ...
... March 15, 2011 UC Irvine,s Center of Excellence ... of two-year grants that will allow the university to ... The first grant, $350,000 from the Long Beach-based Archstone ... services to elder abuse victims in Orange County and ...
... , TUESDAY, March 15 (HealthDay News) -- Most ... nuclear plant crisis such as the one now unfolding in ... Council of State and Territorial Epidemiologists said that "38 (76 ... including 26 of the 31 states with nuclear power plants." ...
Cached Medicine News:Health News:Fido May Help Keep You Fit 2Health News:Fido May Help Keep You Fit 3Health News:New device holds promise of making blood glucose testing easier for patients with diabetes 2Health News:New device holds promise of making blood glucose testing easier for patients with diabetes 3Health News:UCI jointly receives CDC grant to combat health care-associated staph infections 2Health News:Malaria drug slows pancreatic cancer growth in mouse models 2Health News:Malaria drug slows pancreatic cancer growth in mouse models 3Health News:Malaria drug slows pancreatic cancer growth in mouse models 4Health News:Grants to support UCI elder abuse prevention efforts 2Health News:U.S. Unprepared for Major Radiation Emergency: Survey 2
300XL System, English (U.K. cord), 100-240 VAC....
Micro-mini fiber optic light....
Micro-mini fiber optic light....
The MC-3 allows for simultaneous use of two lamps, with an additional built-in spare....
Medicine Products: