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RTA 402 Shown to Protect Animals Against Toxicities of Standard,Cancer Treatments

IRVING, Texas--(BUSINESS WIRE)--Jun 29, 2007 - Reata Pharmaceuticals, Inc. today announced the presentation of new preclinical data showing their lead anti-cancer agent, the Synthetic Triterpenoid RTA 402, is effective at protecting against common toxicities caused by traditional cancer treatments. This data was presented at the annual meeting of the Multinational Association of Supportive Care in Cancer (MASSC) in St Gallen, Switzerland.

Reata scientists and collaborators presented data showing that when RTA 402 is given in combination with radiation therapy to rats bearing human lung cancer tumors, the drug protected non-cancerous tissue from radiation damage while simultaneously enhancing the anti-tumor effect of the radiation treatment. The senior author of this presentation was Dr. Stephen Sonis of the Harvard Medical School, a well-known expert on cancer supportive care. RTA 402 is a novel, orally administered targeted therapy that inhibits the transcriptional activity of NF-kB and STAT3. Correlative studies presented at MASSC confirmed that RTA 402 inhibited NF-kB in both tumor and normal tissue and decreased many circulating inflammatory cytokines in the animals including TNF(alpha), MMP-9, IL-6, IL-8, and VEGF. In related studies, administration of RTA 402 reduced the duration and severity of radiation and chemotherapy-induced oral mucositis in hamster models of the disease and improved survival in animals receiving toxic doses of two common chemotherapy treatments, doxorubicin and oxaliplatin.

Confirmation of these preclinical results in the ongoing clinical trials of RTA 402 would make the drug an important addition to current treatment regimens. Radiation and chemotherapy cause unpleasant and life-threatening side effects in cancer patients. These therapy-related side effects are often dose limiting and cause delays in treatment or a reduction in treatment intensity, hampering the anti-cancer
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