Navigation Links
Publication Confirms that EpCAM, the Target for Two of Micromet's,Product Candidates, Is Overexpressed on Cancer Stem Cells of,Certain Cancers

BETHESDA, Md., June 26, 2007 /PRNewswire-FirstCall/ -- Micromet, Inc. , a biopharmaceutical company focusing on the development of novel, proprietary antibody-based products for cancer, inflammatory and autoimmune diseases, announced that a study published recently in the Proceedings of the National Academy of Sciences (1) supports the findings of several other studies that EpCAM (CD326), which is used as the target for Micromet's product candidates adecatumumab (MT201) and MT110, may be suitable as a target for eradication of so called "cancer stem cells" (CSCs). The other studies showed that CSCs from colon (2), breast (3), pancreatic (4) and prostate (5) cancers all express high levels of EpCAM, which, according to these studies, makes these cells particularly capable of causing tumors.

CSCs constitute a small percentage of tumor cells that have the potential to self-renew and to permanently repopulate a tumor with new cancer cells. CSCs appear to be resistant to various chemotherapies, which may be one of the key reasons why most current therapies cannot cure cancer through elimination of all tumor cells (6). Micromet scientists believe that the findings of EpCAM expression by CSCs in many cancers and of EpCAM being a frequently and highly expressed tumor-associated antigen (7, 8), supports Micromet's use of EpCAM for targeted therapeutics.

EpCAM is the target for Micromet's clinical-stage product candidate adecatumumab (MT201), a fully human monoclonal antibody being co-developed with Merck Serono. In addition, Micromet's BiTE(R) product candidate MT110, an anti-EpCAM/CD3-bispecific antibody construct, is currently in late preclinical development. Both product candidates are designed to recognize EpCAM- expressing cancer cells and to instruct cytotoxic cells of the immune system to eliminate such cancer cells.

"The 'seek and destroy' mechanism of our EpCAM-directed therapeutic drug can
'"/>




Page: 1 2 3 4

Related medicine technology :

1. Response Genetics Announces Publication of a Phase III Clinical Trial Demonstrating That Low Levels of ERCC-1 Help to Predict Likelihood of Response to Cisplatin-Based Therapy in Lung Cancer
2. DOR BioPharma Announces Publication Describing Results of Its Multivalent Botulinum Toxin Vaccine BT-VACC
3. Publication on Pixantrone Preclinical Studies Demonstrates Reduced Cardiotoxicity Compared to Equiactive Doses of Doxorubicin and Mitoxantrone
4. Neurologix Announces Publication of Landmark Gene Therapy Study Demonstrating Safety and Statistically Significant Improvement in Patients With Advanced Parkinsons Disease
5. Nuvelo Announces Publication of Phase 2 rNAPc2 Study Results in Journal of American College of Cardiology
6. Critical Therapeutics Announces the Publication of Data for ZyfloCR (Zileuton) Extended-Release Tablets in the Journal of Asthma
7. Nuvelo Announces Publication of Preclinical Study Results Demonstrating the Potential of NTB-A as a New Target for Leukemia and Lymphomas
8. Thallion Announces Publication of ECO-4601 Phase I/II Clinical Data at ASCO
9. Cytogen Reports Publication Validating the Utility of its Proprietary ProChart Database
10. Independent Publication Confirms Growing Therapeutic Challenge of T315I Mutation in Patients with CML, Notes ChemGenex
11. Independent Publication Confirms Growing Therapeutic Challenge of T315I Mutation in Patients with CML, Notes ChemGenex
Post Your Comments:
(Date:7/25/2014)... "Australia Capsule Endoscopy Systems Market Outlook to 2020″, provides ... market. The report provides value, in millions of US ... dollars) within market segments: Photo - ... , Capsule Endoscopy Data Recorders , Capsule Endoscopy ... shares and distribution shares data for each of these ...
(Date:7/25/2014)... , July 25, 2014  CVS Caremark Corporation ... conference call on Tuesday, August 5, 2014, at 8:30 ... second quarter 2014 financial results. An audio ... through the Investor Relations portion of the CVS Caremark ... visit http://info.cvscaremark.com/investors . This webcast will be archived ...
(Date:7/25/2014)... , July 25, 2014  Solanbridge Group Inc ... acquired the majority interest in Buzznbrewz.com and the Letter ... replaced with a fully executed Purchase Agreement. ... stated "We are proud to have Mr. David ... decades of experience in the private sector and developed ...
Breaking Medicine Technology:Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 2Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 3Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 4Australia Capsule Endoscopy Systems Market Analysis and Forecast to 2020 5Solanbridge Group Inc Announces Acquisition of Buzznbrewz.com 2
... Re-Activates the, Tumor Suppressor P53 Inhibited Tumor Growth Synergistically in Preclinical ... ... April 14 ,Peregrine Pharmaceuticals, Inc. (Nasdaq: PPHM ) announced today ... the 2008 Annual Meeting of the American Association for Cancer Research,(AACR) ...
... feedback validates HUYA,s Integrated Co-Development Model for ... ... HUYA Bioscience International,(HUYA), the leader in U.S./China pharmaceutical co-development, ... Drug),consultation with the U.S. FDA for a development-stage compound ...
Cached Medicine Technology:Preclinical Study Presented at AACR Annual Meeting Shows Broad Anti-Cancer Potential of Peregrine's anti-PS Vascular Targeting Antibodies 2Preclinical Study Presented at AACR Annual Meeting Shows Broad Anti-Cancer Potential of Peregrine's anti-PS Vascular Targeting Antibodies 3Preclinical Study Presented at AACR Annual Meeting Shows Broad Anti-Cancer Potential of Peregrine's anti-PS Vascular Targeting Antibodies 4HUYA Bioscience Int'l Announces First Pre-IND Outcome for a Development Stage Compound Sourced From China - HBI-8000, Promising New Cancer Compound 2HUYA Bioscience Int'l Announces First Pre-IND Outcome for a Development Stage Compound Sourced From China - HBI-8000, Promising New Cancer Compound 3HUYA Bioscience Int'l Announces First Pre-IND Outcome for a Development Stage Compound Sourced From China - HBI-8000, Promising New Cancer Compound 4
(Date:7/28/2014)... at North Carolina State University is proposing a new ... ability with age, but don,t necessarily show declines in ... be how motivated older adults are to maintain focus ... wanted to explain the difference we see in cognitive ... professor of psychology at NC State and author of ...
(Date:7/28/2014)... July 28, 2014 Top Northridge dentist ... for new patients. Finding a new dentist can be an ... issues that have gone untreated and worry about how they ... specializes in patients with special concerns and dental needs and ... and right at home. This special coupon can help patients ...
(Date:7/28/2014)... (PRWEB) July 28, 2014 Freeonlinelifeinsuranceleads.com has ... advantages of comparing online life insurance quotes. , Comparing ... 40% of their life insurance costs. Finding affordable coverage ... websites gather quotes from reliable agencies and displays them ... life insurance quotes, clients can find cheaper coverage, but ...
(Date:7/28/2014)... a healthy lifestyle may help childhood cancer survivors reduce ... indicates. Researchers suggested that children with cancer and ... about how their diet and certain behaviors could ... are important because they indicate that adults who were ... influence their own health outcomes," said one of the ...
(Date:7/28/2014)... 2014 Mahendra Trivedi, accompanied by Trivedi ... Online Workshop ‘Consciousness is Power’ on July 26, 2014 ... workshop, participants from all over the world received profound ... deeper connection to their inner guidance system. , On ... various advantages of raising consciousness and thus, enjoying the ...
Breaking Medicine News(10 mins):Health News:Motivation explains disconnect between testing and real-life functioning for seniors 2Health News:Northridge Dentist, Dr. Farshid Ariz, is Now Offering a $100 Coupon for New Patients 2Health News:Comparing Life Insurance Quotes Online Offers 3 Important Advantages! 2Health News:Healthy Habits May Help Childhood Cancer Survivors Avoid Chronic Ills 2Health News:Trivedi Online Workshop ‘Consciousness is Power’ was Huge Success 2Health News:Trivedi Online Workshop ‘Consciousness is Power’ was Huge Success 3
... THURSDAY, March 5 (HealthDay News) -- If you,re over 50, ... third glass of wine as well as you used to, ... adults who are social drinkers can become impaired by alcohol ... University of Kentucky researchers report. , Most studies on ...
... 2009) -- Two highly lethal viruses that have emerged in ... to prevent and treat malaria, according to a new basic ... the Journal of Virology . Due to the study,s ... print issue, and will be highlighted as an,editor,s "spotlight" in ...
... information about potential risk from exposure to medications, chemicals ... about potential risks of taking cold medication or using ... and over the phone. A new Web ... source for finding the latest information about the potential ...
... broccoli, cabbage block protein in disease spread, study says ... based on compounds extracted from cruciferous vegetables such as ... treatment against melanoma, Penn State College of Medicine researchers ... compounds (called isothiocyanates) and selenium slowed production and blocked ...
... Supreme Court ruling against preemption is disastrous for patient ... and clearly elevates trial lawyers and local juries as ... court has decided that federal law does not preempt ... a flood of frivolous liability lawsuits will cause patients ...
... failure, stroke and heart disease are potential complications of ... million Americans. Now research from Tel Aviv University has ... be a risk factor accelerating cognitive decline and dementia. ... from TAU,s Sackler School of Medicine, found that people ...
Cached Medicine News:Health News:Older Adults Get Drunk Faster Than Younger Drinkers 2Health News:Older Adults Get Drunk Faster Than Younger Drinkers 3Health News:Drug blocks two of world's deadliest emerging viruses 2Health News:Drug blocks two of world's deadliest emerging viruses 3Health News:New Online Service Helps Expectant Moms 2Health News:Drugs From Vegetables May Target Melanoma Tumors 2Health News:High Court Ruling Against Preemption Hurts Patients, Helps Trial Lawyers 2Health News:New Tel Aviv University research links diabetes to cognitive deterioration 2
... The ACMI USA Series DUR-8 Durable ... to the entire intrarenal collecting system with ... and superior secondary deflection allow complete intrarenal ... deflection facilitates access to the proximal ureter ...
... combines efficient stone fragmentation, low purchase price, ... clear LED display, automatic probe sensing circuitry, ... probe size. In addition, the AEH-4E has ... can also regulate and control relative power ...
P-Series Cystourethroscope Short Bridge, examining...
Short double-horn bridge for insertion of instruments...
Medicine Products: