Navigation Links
Protein Found to Shield Pancreatic Cancer Cells from,Self-Destruction

HOUSTON, March 20, 2007 - An overexpressed protein protects human pancreatic cancer cells from being forced to devour themselves, removing one of the body's natural defenses against out-of-control cell growth, researchers at The University of Texas M. D. Anderson Cancer Center report in the March issue of Molecular Cancer Research.

The protein tissue transglutaminase, known by the abbreviation TG2, previously has been found by researchers at M. D. Anderson and elsewhere to be overexpressed in a variety of drug-resistant cancer cells and in cancer that has spread from its original organ (metastasized).

"In general, you rarely see overexpression of TG2 in a normal cell," says Kapil Mehta, Ph.D., professor in the M. D. Anderson Department of Experimental Therapeutics, who began 10 years ago studying TG2 as an inflammatory protein.

Mehta and colleagues in the past year have connected TG2 overexpression to drug-resistant and metastatic breast cancer, pancreatic cancer and melanoma.

Expression of TG2 is tightly regulated in a healthy cell, Mehta says, and is temporarily increased in response to certain hormones or stress factors. "However, constitutive expression of this protein in a cancer cell helps confer protection from stress-induced cell death," Mehta says. "We are developing TG2 as a pharmaceutical target and are now working with a mouse model to that end."

The mechanisms by which TG2 might promote drug-resistance and metastasis have remained elusive, the researchers note. In this paper, the M. D. Anderson team shows in lab experiments that inhibiting the protein in pancreatic cancer cells leads to a form of programmed cell suicide called autophagy, or self-digestion.

TG2 was inhibited in two separate ways. First, the researchers blocked another protein known to activate TG2. Secondly, they also directly targeted TG2 with a tiny molecule known as small interfering RNA
'"/>




Page: 1 2 3

Related medicine technology :

1. Near-Patient Testing: The Advantages of C-Reactive Protein in Hematological Testing
2. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
3. Pieris Progresses Proprietary Asthma Program: Validation of Pulmonary Delivery of Anticalin-Based Protein Product Candidate
4. DiObex Presents Phase 2a Data of DIO-902 Demonstrating Trends of Improved Glycemic Control and Significant Reductions of LDL-Cholesterol and C-Reactive Protein
5. New Research Results Show That Investigational Drug Phenoxodiol Targets Cancer Protein, Causing Cancer Cell Death
6. Data Show SuperGens Multi-Targeted Tyrosine Kinase Inhibitor Suppresses Critical Double-Stranded DNA Repair Protein, Rad51
7. Data Presented at AACR Meeting Shows Peregrines Immunocytokine Fusion Proteins Reduce Growth of B-Cell Lymphoma Tumors by 85% in Preclinical Studies
8. Study in Cell by Magen BioSciences Co-Founder David E. Fisher Identifies New Roles in Skin Cancer Prevention for Key Tumor Suppressor Protein
9. The International Myeloma Foundation Says Data Reported at a Global Medical Meeting in Greece Demonstrates Improved Survival for a Wide Range of Myeloma Patients
10. Lupus Foundation of America Statement on Results for Clinical Study of CellCept Released by Aspreva Pharmaceutical Company
11. The Christopher and Dana Reeve Foundation Expresses Disappointment Over President Bushs Veto of the Stem Cell Research Enhancement Act
Post Your Comments:
(Date:7/11/2014)... According to a new market ... (Endoscopes, Endoscopic Operative Devices, and Visualization Systems) - Global ... the global endoscopy devices market was valued at USD ... at a CAGR of 6.8% from 2013 to 2019, ... in 2019. Browse the full Endoscopy Devices Market ...
(Date:7/10/2014)... , July 11, 2014  Major advances ... of cancer are being highlighted in a three-day ... from 10-12 July, 2014.  Renowned national and ... share best practices and exchange knowledge on modern ... accurate and efficient. The Summit ...
(Date:7/10/2014)... 2014  RESMED INC. (NYSE: RMD ) today ... year ended June 30, 2014 results on Thursday, July 31, ... press release with ResMed,s results will be issued after 1:00 ... webcast to discuss operating results and future outlook. ... US Pacific Time and the live webcast of the call ...
Breaking Medicine Technology:Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6Improving quality and access to advanced cancer care in India and South Asia 2Improving quality and access to advanced cancer care in India and South Asia 3Improving quality and access to advanced cancer care in India and South Asia 4Improving quality and access to advanced cancer care in India and South Asia 5ResMed To Announce Fourth Quarter And Fiscal Year-End 2014 Results 2
... 20, 2010 MinuteClinic, the pioneer and largest provider of ... an agreement with the National Patient Safety Foundation to become ... Me 3 health literacy program. MinuteClinic will launch ... clinics located inside select CVS/pharmacy stores in 26 states and ...
... IRVINE, Calif., Dec. 20, 2010 Endologix, Inc. (Nasdaq: ... for aortic disorders, announced today that Guido Neels, Managing ... Endologix Board of Directors. Essex Woodlands was the majority ... in an all stock transaction on December 13, 2010. ...
Cached Medicine Technology:MinuteClinic Becomes First Retail Clinic Provider to Launch Partnership with National Patient Safety Foundation for Ask Me 3™ Program 2MinuteClinic Becomes First Retail Clinic Provider to Launch Partnership with National Patient Safety Foundation for Ask Me 3™ Program 3Endologix Appoints Guido Neels to Its Board of Directors 2Endologix Appoints Guido Neels to Its Board of Directors 3
(Date:7/13/2014)... (PRWEB) July 13, 2014 Athletes with ... recovery period from concussions, according to research presented today ... AOSSM ) Annual Meeting. The research marks the first ... based on the known physical events that occur after ... with a long allele in the (GT)n genotype were ...
(Date:7/13/2014)... July 13, 2014 Fadhits.com is popular ... prom dresses are extremely beautiful. Recently, the company has ... for 2014. What’s more, all these outfits are ... off). , Additionally, the supplier is now offering ... elegant Quinceanera dresses, it has many other designs for ...
(Date:7/13/2014)... Wright & Schulte LLC has learned ... in July of 2015, in U.S. District Court, District ... the discovery process in the South Carolina federal ... over the multidistrict litigation (MDL). The complaints pending in ... who allege that they took the statin medication to ...
(Date:7/13/2014)... MI (PRWEB) July 13, 2014 If Dr. ... program he has just launched at http://www.HealthYourself101.com will ... visceral obesity. , Power has set out to provide ... ill effects that’s actually – dare we say it? – ... program,” says Power, “aims to engage the remote learner – ...
(Date:7/12/2014)... a well-known wedding dress manufacturer and retailer, has added a ... its product line. In addition, the company has launched a ... more benefits for its loyal fans. All its brand ... 72% off. , As a leader in the garment industry, ... a good place for ladies who want to purchase charming ...
Breaking Medicine News(10 mins):Health News:Genetic Factors May Be Responsible for Slowing Concussion Recovery in Athletes 2Health News:Fadhits.com Announces a Special Offer on Elegant Quinceanera Dresses 2Health News:Lipitor Lawsuits Move Forward With Scheduling Of First Bellwether Trial 2Health News:Lipitor Lawsuits Move Forward With Scheduling Of First Bellwether Trial 3Health News:Lipitor Lawsuits Move Forward With Scheduling Of First Bellwether Trial 4Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 2Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 3Health News:Retired Ann Arbor Physician and Professor Wields New Media to Teach Health Science 4Health News:New Collection of Long Graduation Dresses Revealed by Fadhits.com 2
... A genomic study of chronic blood cancer - a precursor ... diagnosis using only a blood test, avoiding the need for ... the Wellcome Trust Sanger Institute identified the SF3B1 gene as ... forms of blood cancer. Myelodysplasia is particularly prevalent among people ...
... Alan Mozes HealthDay Reporter , MONDAY, Sept. 26 ... Dinora Rodriguez. "It was a nightmare." Rodriguez had woken ... not move her arms or even close her eyes. And ... case involving breast implants and a facial scar, gone terribly ...
... Maureen Salamon HealthDay Reporter , MONDAY, Sept. 26 ... half of U.S. primary care physicians believe their own patients ... randomly selected from the American Medical Association Physician Masterfile showed ... too much medical care, while 52 percent think the amount ...
... A large-scale data review by researchers in China of ... the endoscopic procedure to be safe and effective for ... a pooled detection rate of 68.1 percent for all ... be the most common indication, with a relatively high ...
... HealthDay Reporter , MONDAY, Sept. 26 (HealthDay News) ... and radiation, can seriously disrupt a couple,s sex life. ... and women figure out what sorts of treatments for erectile ... during sex. In doing so, they returned some luster to ...
... DiabetesIQ, released this week, challenges people to test their ... as they learn about the complexities of the disease, ... million Californians. Developed as a free download by ... Center and QuantiaMD, a company headquartered in Waltham, Massachusetts, ...
Cached Medicine News:Health News:Researchers uncover gene associated with blood cancers 2Health News:Researchers uncover gene associated with blood cancers 3Health News:Check Plastic Surgeon's Credentials or Risk Tragic Results, Experts Warn 2Health News:Check Plastic Surgeon's Credentials or Risk Tragic Results, Experts Warn 3Health News:Check Plastic Surgeon's Credentials or Risk Tragic Results, Experts Warn 4Health News:Many Doctors Think Patients Get Over-Treated, Study Says 2Health News:Many Doctors Think Patients Get Over-Treated, Study Says 3Health News:Study examining large-scale data of double balloon enteroscopy shows it is safe and effective 2Health News:Study examining large-scale data of double balloon enteroscopy shows it is safe and effective 3Health News:Study examining large-scale data of double balloon enteroscopy shows it is safe and effective 4Health News:Couples Counseling Boosts Sex Lives After Prostate Cancer 2Health News:Couples Counseling Boosts Sex Lives After Prostate Cancer 3Health News:Couples Counseling Boosts Sex Lives After Prostate Cancer 4Health News:Interactive mobile app from UCSF and QuantiaMD teaches people how to manage diabetes 2Health News:Interactive mobile app from UCSF and QuantiaMD teaches people how to manage diabetes 3
Microforceps : Eckardt End & Side Gripping Forceps...
Blunt tipped forceps with a smooth, pliable silicone coating on the entire interior surface of the tip. For removal of foreign bodies or atraumatic tissue grasping....
... As a pioneer in the design ... and extraction of viscous fluids, D.O.R.C. is ... the combination of injection and extraction in ... provides controlled injection of viscous fluids, such ...
Anterior chamber protein cell meter. Laser flare meter and cell-counting functions are included in this cell meter, with dramatically enhanced measurement of cell volume....
Medicine Products: