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Promising Data on Cognitive Effects of Safinamide in Early,Parkinson's Disease

day dose-range based on UPDRS scoring.

The cognition component of the trial was a secondary endpoint and was carried out in selected centers, equipped to perform this type of assessment.
2 Strategic Target Detection Test (complex attention, executive function): This test requires the subject to touch the target stimuli (shapes) directly of a touch screen. The participant must learn which target is correct by choosing one of the stimuli following computer-generated feedback.
3 Auditory Number Sequencing (attention, working memory, executive function): Subjects hear a series of numbers (e.g. “9.. 3.. 6“; minimum=2 digits, maximum=8 digits) and are asked to repeat the numbers in order, from lowest to highest, requiring both working memory maintenance and manipulation.

About safinamide
Safinamide is an alpha-aminoamide derivative which is orally administered. Safinamide is believed to have a novel mode of action as a dopamine modulator (comprising both selective and reversible MAO-B inhibition and also blockade of dopamine reuptake) complemented by an effect on the glutamate pathway. Studies suggest that safinamide may combine the inhibition of dopamine re-uptake and MAO-B, two key mechanisms involved in the control of dopamine concentration in the brain, and inhibition of glutamate release. If regulatory approvals are obtained, Merck Serono and Newron believe that safinamide, as an adjunctive treatment to dopamine agonists and levodopa, may have a competitive advantage over current therapies for Parkinson’s disease.

About Parkinson’s disease
Parkinson's disease is a degenerative disorder of the central nervous system that often impairs the sufferer's motor skills and speech. Parkinson's disease belongs to a group of conditions called movement disorders. It is characterized by muscle rigidity, tremor, a slowing of physical movement (bradykinesia) and, in extreme cases, a loss of physi
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