Navigation Links
Prolexys Pharmaceuticals and Columbia University Researchers,Publish Study on Anti-Tumor Properties of a Selective Small,Molecule Anti-Tumor Agent With Novel Mechanism of Action

the approach revealed a novel cell death pathway," said Dr. Stockwell.

Prolexys launched a medicinal chemistry effort in 2005 to create small molecule analogs of erastin with improved pharmaceutical properties. This effort resulted in the identification of a close structural analog, PRLX 93936, which shows improvement in potency, solubility, and in vivo activity, compared to erastin. PRLX 93936 shows robust and selective toxicity in a wide variety of tumor cell-lines, and causes complete tumor regression in mouse xenograft models of fibrosarcoma, pancreatic cancer, ovarian cancer, colon cancer, and melanoma. Prolexys plans to file an Investigational New Drug (IND) Application for PRLX 93936 with the U.S. Food and Drug Administration (FDA) in June, 2007. Although PRLX 93936 was created as a result of screening hundreds of erastin-related small molecules, its molecular mechanism of action may differ from those of erastin. "Prolexys and collaborators continue to work towards understanding the molecular basis of the unique tumor-selective mechanism of action of erastin and PRLX 93936," said Dr. Sudhir Sahasrabudhe, Chief Scientific Officer of Prolexys Pharmaceuticals.

"The approach described in this paper is a powerful way to identify and test small molecule therapeutics and translate them into the clinic in a time- efficient and cost-efficient manner. We are very excited about evaluating the therapeutic potential of molecules with novel mechanisms of action, such as PRLX 93936 in patients with pancreatic cancer and other solid tumors," said Dr. Daniel Von Hoff, Principal clinical investigator of PRLX 93936, and TGen's Physician-in-Chief and Director of TGen's Clinical Research Service in Scottsdale, Arizona

About Prolexys Pharmaceuticals: Prolexys Pharmaceuticals, Inc. is a privately held biopharmaceutical company focused on discovering small molecule drugs that act on novel therapeutic targets. The Company's therapeutic focus is in cancer and res
'"/>




Page: 1 2 3

Related medicine technology :

1. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
2. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
3. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
4. Auxilium Pharmaceuticals to Present at the 2007 CEUT Emerging Growth Opportunities Conference
5. Sunesis Pharmaceuticals to Present at the C. E. Unterberg, Towbin Emerging Growth Conference
6. EPIX Pharmaceuticals to Present at the C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
7. Pro-Pharmaceuticals Updates Progress of Clinical Trials & Davanat 505 (b)(2) Filings
8. Cosmo Pharmaceuticals Reports Positive Preliminary Phase II/III Data with Rifamycin MMX in Infectious Diarrhea
9. Portola Pharmaceuticals Announces Positive Phase II EXPERT Results and Additional Oral and Poster Presentations at the XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH)
10. Cyclacel Pharmaceuticals Announces Results of Phase II Seliciclib Combination Studies
11. Arisaph Pharmaceuticals Announces Results of its Potent Smart DPP-4 Inhibitor, ARI-2243, at the ADA
Post Your Comments:
(Date:5/29/2015)... 28, 2015 Research and Markets ( http://www.researchandmarkets.com/research/p37spr/north_america ... America Open System MRI Market - Growth, Trends And ... The key players in the industry are ... Healthcare and Toshiba Medical Systems ... CT because of its higher sensitivity and use of ...
(Date:5/29/2015)... Massachusetts and SPARTANBURG, South Carolina ... The Guardian Research Network and Molecular Health have announced ... and molecular diagnostic decision support to the majority of ... Guardian Research Network will collaborate with Molecular Health to ... testing to identify cohorts from hundreds of thousands of ...
(Date:5/29/2015)... , May 29, 2015  Haemonetics Corporation (NYSE: ... , Chief Operating Officer, will present at the JMP ... on June 23 rd , 2015 at ... access Mr. Davies, presentation live via webcast at: ... (NYSE: HAE ) is a global healthcare company ...
Breaking Medicine Technology:North America Open System MRI Market 2014-2019 with GE, Hitachi Medical, Philips Healthcare, Siemens Healthcare and Toshiba Medical Dominating 2New Collaboration to Dramatically Expand Therapeutic Clinical Trial Access for Cancer Patients Across the United States 2New Collaboration to Dramatically Expand Therapeutic Clinical Trial Access for Cancer Patients Across the United States 3New Collaboration to Dramatically Expand Therapeutic Clinical Trial Access for Cancer Patients Across the United States 4
(Date:5/30/2015)... 30, 2015 On Thursday, May ... Charles Simone and Dr. Evan Alley both of ... the Mesothelioma Experts’ series. The interview was part ... centers of excellence. Drs. Simone and Alley were ... Hesdorffer, with whom they discussed the mesothelioma program ...
(Date:5/30/2015)... May 30, 2015 Nicole Blodgett, ... Disability Income Associate (DIA) designation to further her ... designation is designed for insurance advisors, health care ... their knowledge and expertise associated with the risk ... DIA designation is only the latest accomplishment in ...
(Date:5/30/2015)... May 30, 2015 San Luis ... she is offering a free analysis and consultation for ... coincides with Disability Awareness Month, which was created by ... across the United States such as Polk recognize the ... awareness about the possibility of disability, as well as ...
(Date:5/30/2015)... 30, 2015 A live auction will ... equipment from hospitals, surgery centers and other medical facilities ... be sold including radiology, surgery, endoscopy, lab, anesthesia, exam ... take place Tuesday, June 2nd starting at 10:00am EDT. ... at 5025 North Hiatus Rd., Sunrise, FL 33351. ...
(Date:5/29/2015)... MO (PRWEB) May 29, 2015 Based in ... autism awareness shirts for a couple of months ... Their latest release, which reads “I’m not misbehaving, I ... worn by the parent’s of an autistic child in order ... of autism. , Not only are they raising awareness through ...
Breaking Medicine News(10 mins):Health News:Interview with Mesothelioma Experts, Drs. Simone and Alley Now Available on Demand 2Health News:Secura Consultants Expands Disability Insurance Expertise 2Health News:San Luis Obispo Insurance Agent Susan Polk Offering Complementary Insurance Analysis In Honor Of Disability Awareness Month 2Health News:Centurion to Sell Surplus Medical Equipment in Online and On-site Auction 2Health News:La La Land Shirts Is Busy Spreading Autism Awareness with Complimentary Shipping on Their New Shirt 2
... to a recent study researchers find people who get only four ... in turn could lead to weight gain. ,An investigation ... appetites were measured before the study started, after they had slept ... had slept about 10 hours a night for two nights. Levels ...
... transplantation procedure that will most likely help patients with ... been implemented by a team of Chennai doctors.// ... and Plasmapheresis,' enables patients with renal failure to accept ... "Through this technique we temporarily blind the function of ...
... recent study researchers estimated the likely extent of the cancer ... in // various developed countries. ,Investigators report the ... percent to over 3 percent in Japan. Japan has the ... the United Kingdom, researchers say the risk of cancer was ...
... as many as 14 percent of pregnant women suffer ... use antidepressants during pregnancy. Studies involving infants exposed to ... ill effects, so most doctors believe these drugs can ... have only compared major outcomes, such as physical growth ...
... chronic chest pain sufferers exercise longer. When the drug ranolazine ... to improve the total exercise time of patients with symptoms ... review by the FDA. For this study, more than 800 ... a placebo or one or two doses of ranolazine. Patients ...
... arthritis is a chronic inflammatory disease of the immune ... researchers say // people consuming high amounts of red ... . ,Researchers compared 88 rheumatoid arthritis patients, ... and women between the ages of 45 and 70, ...
Cached Medicine News:
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: