Navigation Links
Progen's Phase 2 Liver Cancer Trial Exceeds Efficacy Objective

- Phase 3 Patient Enrolment Planned for Second Half of 2007 -

BRISBANE, Australia, April 16, 2007 /PRNewswire-FirstCall/ -- Progen Pharmaceuticals Limited today announced the final stage 1 results of its Phase 2 trial of PI-88 in patients who had previously undergone surgical removal of liver cancer. The 48 week data demonstrated that 160 mg of PI-88 showed an improvement in disease-free rate, the primary endpoint, of 25 percent and prolonged the time to tumour recurrence (disease- free survival) from 27 to 48 weeks, or by 78 percent, building on the 30-week results announced in December 2006.

The first stage of the randomised, two-stage multi-centre Phase 2 trial was designed to determine the appropriate dosage and possible efficacy of PI- 88 in reducing tumour recurrence in liver cancer patients who had previously undergone surgical removal of the cancer. Patients in this stage of the Phase 2 trial were randomly assigned to one of three groups to receive either the standard of care (with no PI-88 treatment), 160 mg of PI-88, or 250 mg of PI- 88, over 36 weeks with a 12 week follow-up period.

    Summary of results

    -- Treatment with 160 mg of PI-88 increased the disease-free rate by

       approximately 25 percent, from 50 percent to 63 percent at 48 weeks

    -- Treatment with 160 mg of PI-88 increased the time to recurrence of

       disease (disease-free survival) by approximately 78 percent, from 27 to

       48 weeks

    -- The final results confirmed the trend identified in the 30-week

       assessment that PI-88 delayed the recurrence of disease and increased

       the likelihood that the patient would be disease free for a longer

       period

    -- The 160 mg dosing level of PI-88 revealed a strong safety and

       tolerability profile and few adverse events directly or possibly

       related to treatment

As the 160mg dose was well tolerated and showed
'"/>




Page: 1 2 3

Related medicine technology :

1. Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
2. Phase 3 Results for Dabigatran Etexilate, an Investigational Oral Anticoagulant, Presented Today at the XXIst Congress of the International Society on Thrombosis and Haemostasis
3. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
4. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
5. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
6. Actemra (tocilizumab) Third Phase III Study Results Show Significant Improvement in Symptoms of Patients with Rheumatoid Arthritis
7. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
8. NexMed Announces Completion of Patient Enrollment in Two Pivotal Phase 3 Studies for Anti-Fungal Product
9. AM-Pharma Announces Positive Results of Phase IIa Clinical Trial with Alkaline Phosphatase For Ulcerative Colitis
10. Phase III Trial Results Show Superiority of Rivaroxaban over Enoxaparin for the Prevention of Venous Thromboembolism in Patients Undergoing Knee Replacement Surgery
11. Phase III Trial Results Show Superiority of Rivaroxaban over Enoxaparin for the Prevention of Venous Thromboembolism in Patients Undergoing Knee Replacement Surgery
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Progen Phase Liver Cancer Trial Exceeds Efficacy Objective
(Date:11/26/2014)... , Nov. 26, 2014 The medical ... a rate of 4%, with world market revenues ... Information. MRI and other types of medical imaging ... treatment of numerous medical conditions in children and ... techniques. Kalorama,s report, Medical Imaging Markets , ...
(Date:11/26/2014)... 25, 2014  At the American Dental Association,s Annual ... October, KaVo Kerr Group was honored to be part ... the opportunity to see and test the Best of ... deliver lectures on the latest developments in dental technology. ... new DEXIS CariVu Caries Detection Device and Kerr Demi ...
(Date:11/26/2014)...  Medtronic,s roughly $43 billion acquisition and ... in the media for its US Federal tax ... player in one of the fastest growing device ... research firm said  the two companies compete in ... of solutions spanning inpatient to home care, and ...
Breaking Medicine Technology:Kalorama: Steady Growth in the Medical MRI Market 2Kalorama: Steady Growth in the Medical MRI Market 3KaVo Kerr Group Showcased in Pride Institute Technology Expo at ADA Annual Meeting 2KaVo Kerr Group Showcased in Pride Institute Technology Expo at ADA Annual Meeting 3Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 2Medtronic - Covidien: Beyond Taxes, Deal Will Create Patient Monitoring Power, according to Kalorama Information 3
(Date:11/26/2014)... Vultures have developed highly specialized ways of dealing with ... researchers report. The new research investigated the different ... the guts of 50 turkey vultures and black vultures ... the vultures had more than 500 different types of ... found. The findings suggest that a vulture,s digestive ...
(Date:11/26/2014)... number of emergency department visits in the United States rose ... million in 2011, according to the U.S. Centers for Disease ... people were going to ERs with non-urgent medical needs: 96 ... two hours of arriving at the ER. In 2010, that ... percent of patients arrived at the ER after normal business ...
(Date:11/26/2014)... HealthDay Reporter TUESDAY, Nov. 25, ... U.S. Food and Drug Administration will have many restaurant chains ... apply to movie theater popcorn and ice cream parlor fare. ... from home, often consuming less nutritious food and underestimating the ... a Monday afternoon news conference. Although listing calorie ...
(Date:11/26/2014)... need to take an active role in protecting their ... must make sure sports-playing teens have the right protective ... the American Migraine Foundation and a professor of medicine ... Ariz. in an American Migraine Foundation, said in a ... teens sports needs to have appropriate training. Teen sports ...
(Date:11/24/2014)... November 24, 2014 From embedded sensors and ... of fitness technology will take center stage at the ... at the 2015 International CES® , January 6, ... Level 2, Bellini 2004). The bond between fitness and technology ... less about devices and more about the human body. , ...
Breaking Medicine News(10 mins):Health News:ER Visits on the Rise, Study Reports 2Health News:Calorie Counts Mandated at Chain Restaurants, FDA Says 2Health News:Calorie Counts Mandated at Chain Restaurants, FDA Says 3Health News:Parents Need to Take Lead on Teen Concussion Prevention 2Health News:Next Wave Fitness Products Debut at FitnessTech Summit Living in Digital Times at the 2015 International CES 2Health News:Next Wave Fitness Products Debut at FitnessTech Summit Living in Digital Times at the 2015 International CES 3Health News:Next Wave Fitness Products Debut at FitnessTech Summit Living in Digital Times at the 2015 International CES 4
... American Botanical Council (ABC) has officially launched its Adopt-an-Herb ... tea ( Camellia sinensis ). For the next three ... to ensure that abstracts (summaries) of the latest published ... within ABC,s HerbMedPro database, one of the most robust ...
... American Life League will feature two of the most ... and Activism Week and Personhood Conference Jan. 21-23. , ... , , The TAW will ... launched the Born Alive Truth campaign during the 2008 presidential ...
... third of patients with suspect scans develop the disease within ... -- Among people whose brain scans show signs of multiple ... within about five years, researchers say. , The study ... variety of reasons, including migraines or head trauma. The scans ...
... , Company Appoints Tami Booth Corwin To New Position ... NEW YORK, Dec. 10 In its first major offline ... publisher of self-improvement books and products, to publish THE SPARK: ... Your Life. The book will give readers a proven ...
... racing to develop drugs that use the gene silencing mechanism ... Now, a new study opens up an entirely new possibility ... have demonstrated for the first time that RNA interference can ... , "Our data suggest that, at least in an ...
... Pharmaceuticals, Inc. ("Napo"),is pleased to announce a collaboration ... crofelemer for all indications in North America,Europe (excluding ... Crofelemer is Napo,s novel anti-secretory,gastrointestinal agent currently ... treatment of,chronic diarrhea in people living with HIV/AIDS ...
Cached Medicine News:Health News:Tea Dragon Films is First Adopter in the American Botanical Council's New Adopt-An-Herb Program 2Health News:Tea Dragon Films is First Adopter in the American Botanical Council's New Adopt-An-Herb Program 3Health News:Tea Dragon Films is First Adopter in the American Botanical Council's New Adopt-An-Herb Program 4Health News:A.L.L. Personhood Conference Features Pro-Life New Media Stars 2Health News:MRI Can Spot Presymptomatic MS 2Health News:Top Online Health & Lifestyle Media Brand Inks Major Book Deal 2Health News:Top Online Health & Lifestyle Media Brand Inks Major Book Deal 3Health News:Study first to show that RNA interference can facilitate vaccine development 2Health News:Study first to show that RNA interference can facilitate vaccine development 3Health News:Napo Pharmaceuticals Announces License of Crofelemer to Salix Pharmaceuticals 2Health News:Napo Pharmaceuticals Announces License of Crofelemer to Salix Pharmaceuticals 3Health News:Napo Pharmaceuticals Announces License of Crofelemer to Salix Pharmaceuticals 4Health News:Napo Pharmaceuticals Announces License of Crofelemer to Salix Pharmaceuticals 5
... Plume-inator produces the strongest vacuum ... smoke evacuators. The unit ... hospital grade plug, footswitch, built-in ... purpose swing ring to hold ...
A system for the removal and filtration of laser and surgical smoke....
Stryker Instruments, the leader in surgical helmets, offers its 4th generation of personal protection systems for todays surgical environment the Sterishield T4 System....
... The PS Medical Strata valve is ... the resistance properties of the valve can ... is designed to minimize overdrainage of cerebrospinal ... within a normal physiologic range, regardless of ...
Medicine Products: