Navigation Links
Prexige Study Shows Significantly Less Impact on Blood Pressure,Than Ibuprofen in Osteoarthritis Patients with Controlled,Hypertension

* New data from 741-patient trial show those treated with Prexige experienced significantly smaller impact on blood pressure compared to ibuprofen[1]

* Many patients with osteoarthritis also have high blood pressure; even small changes in blood pressure can impact cardiovascular risk[2],[3]

* Prexige approved in more than 50 countries and currently under review in US for use in osteoarthritis patients

BASEL, Switzerland, June 15, 2007 - Patients with osteoarthritis who also have controlled hypertension experienced a slight decrease in average daily blood pressure when treated with the selective COX-2 inhibitor Prexige® (lumiracoxib) compared to a slight increase in those taking ibuprofen, a commonly-used non-steroidal anti-inflammatory drug (NSAID)[1].

These new results, presented today at the Annual European Congress of Rheumatology (EULAR) in Barcelona, are important because around 40% of patients with osteoarthritis also have high blood pressure (or hypertension)[4],[5].

Independent research shows that even small elevations in blood pressure can contribute to an increased risk of cardiovascular events[2],[3],[6],[7],[8]. Osteoarthritis is the most common form of arthritis affecting 139 million people worldwide[9].

"NSAIDs, including some COX-2s, have been associated with raised blood pressure, and this effect may be in part responsible for the increased risk of cardiovascular disease associated with this class of medications," said Tom MacDonald, Ph.D., Professor of Clinical Pharmacology at the Hypertension Research Centre at Ninewells Hospital & Medical School in Dundee, Scotland. "These data indicate that lumiracoxib may have less impact on blood pressure than the most commonly used NSAID ibuprofen."

Prexige, which is given to patients as a 100 mg once-daily tablet, is approved for use in certain types of patients with osteoarthritic pain of the knee
'"/>




Page: 1 2 3 4 5 6

Related medicine technology :

1. Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer
2. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
3. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
4. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
5. Reaction to Avandia Warnings Stronger Among Internists Than Endocrinologists, According to Study by GfK Market Measures
6. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
7. Actemra (tocilizumab) Third Phase III Study Results Show Significant Improvement in Symptoms of Patients with Rheumatoid Arthritis
8. Protox Announces Positive Clinical Data from Prostate Cancer Study
9. International ENDORSE Study Shows That the Majority of Hospitalized Patients Surveyed are at Risk for VTE and Many do not Receive Recommended VTE prophylaxis
10. New Study Shows That Extending Prophylaxis With Clexane / Lovenox (enoxaparin Sodium Injection) to 5 Weeks is More Effective Than 10 Days for Reducing the Risk of Venous Thromboembolism (VTE) in Acutely ill Medical Patients With Reduced Mobility
11. Genzyme Announces Data from First Phase 3 Study of Tolevamer in Patients with C. difficile Associated Diarrhea

Post Your Comments:
(Date:11/20/2009)...ov. 20 The United States Court of ...istrict Court ruling yesterday, approving a settle...AWP) pharmaceutical litigation against AstraZeneca...newscom.com/cgi-bin/prnh/20080317/AQM144LOGO ) ,...nsumers who purchased the pharmaceutical giant,s p...
(Date:11/20/2009)... Nov. 20 Cornerstone The...aceutical company focused on acquiring, developing...y for the respiratory and related markets, today r... the Food and Drug Administration ("FDA") alleging...ine HCl 10 mg, Pyrilamine Maleate 16 mg) and Decon...
(Date:11/20/2009)...l., Nov. 20 /PRNewswire-FirstCall/ -- Landauer,...r the fiscal fourth quarter and full year of 2009 ... company will host a conference call for investors...n Time. Investors may access the live call by dial...ada), or 480-629-9835 (international callers), or ...
Breaking Medicine Technology:U.S. Court of Appeals Upholds AstraZeneca AWP Settlement 2U.S. Court of Appeals Upholds AstraZeneca AWP Settlement 3Cornerstone Therapeutics Provides a Response to FDA Warning Letter on Deconsal 2Cornerstone Therapeutics Provides a Response to FDA Warning Letter on Deconsal 3Landauer, Inc. Sets Date and Time for Announcement of Fiscal Fourth Quarter and Full Year 2009 Results 2Drug eluting stents better than bare metal stents for heart attack patients 58360 1Drug eluting stents better than bare metal stents for heart attack patients 58360 2NIH fellowship recipient to study disease ecology 10115 1NIH fellowship recipient to study disease ecology 10115 2NSF funds states first imaging system for UAB microscale research lab 10112 1NSF funds states first imaging system for UAB microscale research lab 10112 2
(Date:11/20/2009)...S, Nov. 20 Centene Cor...ll present at the Bank of America Merrill Lynch 20...9, at the Crowne Plaza Hotel Times Square in New Y...cember 2nd at 8:30 a.m. Eastern Time. Investors an...o webcast of Centene,s presentation at: http://ww...
(Date:11/20/2009)...EM, N.C., Nov. 20 Samue...o redefine what it means to be "happy" during the ...h a specialty in family counseling and chair of th...ty, Gladding says research shows that it is the pr... even depression during the holidays. ,, That,s...
(Date:11/20/2009)...RK, Nov. 20 SIRIUS XM R...l broadcast Doctor Radio Reports: What Every Wo...pecial hosted by veteran journalist Perri Peltz. ...20080819/NYTU044LOGO ) ,, Doctor Radio Repor...s will air November 21 live at 10:00 am ET on D...
(Date:11/20/2009)...posure to formaldehyde used for embalming in the f...risk of death from myeloid leukemia, according to ...ournal of the National Cancer Institute . , Prev...hohematopoietic malignancies and brain cancer in a...ers, all of whom may have worked with formaldehyde...
(Date:11/20/2009)...) November 20, 2009Emergency medical service (EMS)...d 350,000 cardiac arrests each year. Only 5 to 10...survive. Better quality cardiopulmonary resuscita...ay be associated with better patient outcome. The...rgest clinical research network to study prehospit...
Breaking Medicine News(10 mins):Health News:Why Holidays Don't Have To Be 'Happy' 2Health News:SIRIUS XM to Broadcast 'Doctor Radio Reports: What Every Woman Needs To Know About Mammograms' 2Health News:SIRIUS XM to Broadcast 'Doctor Radio Reports: What Every Woman Needs To Know About Mammograms' 3Health News:SIRIUS XM to Broadcast 'Doctor Radio Reports: What Every Woman Needs To Know About Mammograms' 4Health News:SIRIUS XM to Broadcast 'Doctor Radio Reports: What Every Woman Needs To Know About Mammograms' 5Health News:Funeral industry workers exposed to formaldehyde face higher risk of leukemia 2Health News:Effect of real-time CPR feedback reported at resuscitation science symposium 2Health News:Effect of real-time CPR feedback reported at resuscitation science symposium 3
...onmental issue no one's talking about," regrets C...tivist and founder of the Work Less Party, a Vanco... work week. "As a society, we're working exp...ns work more hours than anyone else in the industr...
...s? Women willing to perform oral sex can get away ...that was the experience of a porn star. She says s... the roadside tryst. The allegations have led to a...ndy Moss, declined to comment Tuesday. Highway Pat...
... gum disease periodontitis, may have an increased ... smoke. Periodontitis is an oral infection...vidence suggests the involvement of viruses as wel...er Institute, Buffalo. As part of the stud...
...of virgin birth in cartilaginous fish, after busti... an aquarium, that had only female sharks which h... The birth of the pup at Omaha's Henry Doorl...le sharks have an organ that can store sperm, but ...
...n favour of a ban on smoking in workplaces and ind... Some 88 percent of citizens in the European Uni...indoor spaces, said a study by the European Commis...lic and work places smoke-free by 2009. Wh...
...ries like Indonesia, the Unjted Nations health bod...sed efforts would be made to ensure "fair and equi...at affordable prices in the event of a pandemic." ...ed by the World Heath Assembly. The discussion o...
Other Medicine News:Health News:Work Less to Sustain Planet Earth, Say Activists 2Health News:Work Less to Sustain Planet Earth, Say Activists 3Health News:Policeman in Trouble for Seeking Oral Sex in Return for a Favour 2Health News:Men With Chronic Gum Disease at Higher Risk of Tongue Cancer 2Health News:WHO Announces Deal on Sharing Bird Flu Virus 2
Alvis Foreign Body Spud
Nicati Foreign Body Spud
Golf Club Spud
Spud & Gouge Needles
Medicine Products: