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Preterm Infants with Respiratory Distress Syndrome: Incidence Rates,of Death when Treated with Surfactant Replacement Therapies

ong RDS babies treated with poractant alfa at an initial dose of 200 mg/kg than with beractant. Results from this large database analysis are consistent with the findings of our trial and other similar trials comparing poractant alfa and beractant. Furthermore, these analyses also demonstrated statistically significant survival benefits with poractant alfa treatment when compared with the other two natural surfactants available for clinical use in the United States. These results suggest that neonatologists should carefully weigh their choice of surfactant therapy in their clinical practice."

The study presented today was supported by a research grant from Chiesi Farmaceutici of Parma, Italy, manufacturer of Curosurf(R) Intratracheal Suspension, and Dey, L.P., US marketer of Curosurf(R).

"We are pleased to have supported this study and are impressed with its results," said J. Melville Engle, President and Chief Executive Officer of Dey, L.P. "To the extent that these data will affect clinical practice, these outcomes bode well for the health of premature infants and the peace of mind of their families."

Paolo Chiesi, Vice President, R&D Director of Chiesi Farmaceutici, concurred: "Curosurf(R) is already the most widely used surfactant in the world, and we look forward to its being used to treat more babies suffering from RDS in the United States. We are delighted that this large data analysis so strongly validates the clinical value of Curosurf(R)."

About Curosurf(R)

Curosurf(R) Intratracheal Suspension is indicated for the treatment (rescue) of RDS in premature infants. Curosurf(R) reduces mortality and pneumothoraces associated with RDS.

Curosurf(R) Intratracheal Suspension compensates for the deficiency of surfactant in preterm infants with RDS and restores surface activity to the lungs of these infants. Because Curosurf(R) works rapidly, infants should receive frequent clinical and laboratory assessments so that oxyg
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