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Presentations at American College of Cardiology Meeting Highlight,New Opportunities for HDL Therapy

HDL Therapy platform (HDL Selective Delipidation and HDL Mimetic Peptides) aims to develop treatments to reverse atherosclerosis, a disease of blood vessels, caused by the build-up of cholesterol-filled plaques in the vascular system and, most critically, in the coronary arteries. If left untreated, these plaques are highly vulnerable to rupture and to blood clot formation, which can result in a fatal myocardial infarction (heart attack). Our HDL Therapy platform increases the functionality of existing HDL in a patient not simply the quantity of HDL. We are currently in a "first in man" clinical trial at the Washington Hospital Center (Washington, D.C.) to evaluate the safety and feasibility of our Plasma Delipidation System (PDS-2) in subjects with prior Acute Coronary Syndrome. A secondary objective of this trial is to assess methods of analysis of data collected by IVUS. Measurements of segment plaque volume, percentage atheroma volume, plaque thickness, discrete lesion analysis, and other IVUS variables will be analyzed and employed to select effectiveness endpoints for a future study. The IVUS analysis will be conducted at two core IVUS laboratories: at the Cardiovascular Research Institute at the Washington Hospital Center by Dr. Neil Weissman, Director of the Cardiac Ultrasound and Ultrasound Core Laboratories, and at Stanford University Medical Center by Dr. Peter J. Fitzgerald, Director of the Center for Research in Cardiovascular Interventions and the Cardiovascular Core Analysis Laboratory. We expect to complete this trial during the second half of 2007 and start an effectiveness trial in early 2008.

Lipid Sciences, Inc. is a development-stage biotechnology company engaged in the research and development of products and processes intended to treat major medical indications, in which lipids, or fat components, play a key role. The Company's HDL Therapy platform (HDL Selective Delipidation and HDL Mimetic Peptides) aims to develop treatments to rever
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