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Presentations at American College of Cardiology Meeting Highlight,New Opportunities for HDL Therapy

ts taking statins continue to have clinical events, and increasing HDL has been widely accepted as a potential major new approach in reducing the residual risk of a heart attack or stroke in high-risk patients taking statin drugs. The results obtained with the imaging techniques, including IVUS, clearly indicate that imaging trials can be an effective way to obtain and assess data which can be useful in determining the potential of new HDL therapies. Existing epidemiological data and pre-clinical animal studies continue to provide us with overwhelming evidence that higher levels of HDL, or increasing the functionality of existing HDL, will result in reduced cardiovascular disease. Twenty years after the introduction of statins, HDL therapy is clearly now the new frontier. The field is wide open to pursue innovative solutions focused on HDL therapy, and the unmet clinical need is clear."

In a recent study report in the March 26, 2007 issue of The New England Journal of Medicine, Dr. John J.P. Kastelein, Academic Medical Centre, University of Amsterdam, and member of the Lipid Sciences' Scientific Advisory Board noted, that even with the most aggressive treatment, (statin) drugs reduce the risk of a major coronary event by only 30%. This finding, combined with a projection that mortality from cardiovascular causes will increase worldwide by 90% by the year 2020, as compared with that in 1990, illustrates the need for new efficacious treatments for cardiovascular disease.

Furthermore, as an industry expert, Dr. Brewer was recently featured in a Medscape interview, "Raising High-Density Lipoprotein Cholesterol: What Are We Learning From the Torcetrapib Experience?" providing perspective on the current state of HDL Therapy and its future potential. The full text of the article will be available on our website: www.lipidsciences.com at the Lipid Sciences in the News heading.

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