Navigation Links
Preclinical Study Finds Protease Inhibitor-Resistant HIV May Have,Reduced Potential to Develop Resistance to Panacos' Bevirimat

e CA-SP1 junction and has been observed previously in bevirimat resistance generation studies. The CSHL conference presentation concluded that bevirimat resistance may be less likely to arise in PI-resistant HIV strains.

Dr. Graham P. Allaway, Panacos' President and Chief Operating Officer commented, "Clinical studies to date suggest resistance to bevirimat does not develop rapidly, in contrast to some currently marketed HIV drugs, possibly because there is selective pressure to maintain the integrity of the capsid-SP1 cleavage site sequence, which is highly conserved among HIV strains. While resistance tends to develop eventually to all HIV inhibitors, the new study suggests there may be a greater hurdle to bevirimat resistance development in patients with PI-resistant virus. These patients represent one of the major groups who could potentially benefit from novel-mechanism HIV drugs such as bevirimat."

About Panacos

Panacos is developing the next generation of anti-infective products through discovery and development of small molecule oral drugs for the treatment of HIV and other major human viral diseases. HIV infects approximately 1.7 million people in North America and Western Europe and approximately 40 million people worldwide. Approximately 650,000 patients are treated annually for HIV in the United States and Western Europe. Resistance to currently available drugs is one of the most pressing problems in HIV therapy and the leading cause of treatment failure. Panacos' proprietary discovery technologies are designed to combat resistance by focusing on novel targets in the virus life cycle, including virus maturation and virus fusion.

Panacos' lead candidate, bevirimat (PA-457), is the first in a new class of oral HIV therapeutics under development called maturation inhibitors, discovered by Panacos scientists and their academic collaborators. Based on its novel mechanism of action, bevirimat is designed to have potent activity agai
'"/>




Page: 1 2 3

Related medicine technology :

1. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
2. Gene Therapy Eradicates Pancreatic Cancer in Preclinical Trial Targeting Systems Success in Mouse Model Reported in Cancer Cell
3. YM BioSciences Announces Preclinical Data Confirming Nimotuzumab Binds to the EGF Receptor and Potentiates Radiotherapy
4. ZIO-101 (Darinaparsin) Interim Phase II and Preclinical Data Presented at International Myeloma Workshop
5. ACE-011 Improves Multiple Myeloma Bone Disease in a Preclinical Model
6. Publication on Pixantrone Preclinical Studies Demonstrates Reduced Cardiotoxicity Compared to Equiactive Doses of Doxorubicin and Mitoxantrone
7. Genaera Presents Preclinical Data on Trodusquemine (MSI-1436) for the Treatment of Obesity at the American Diabetes Association 67th Scientific Session
8. Elixir Pharmaceuticals Presents Preclinical Data Highlighting Its Ghrelin Antagonist Program at the American Diabetes Associations Annual Meeting
9. Genaera to Present Preclinical Data on Trodusquemine for the Treatment of Obesity at the American Diabetes Association 67th Scientific Sessions
10. Metabasis Therapeutics Presents Results of Preclinical Studies for MB07811, Its Novel Product Candidate for the Treatment of Hyperlipidemia, at the Endocrine Societys Annual Meeting
11. Elixir Pharmaceuticals Presents Additional Preclinical Data Demonstrating the Potential of Ghrelin Antagonism to Regulate Metabolism, Body Weight and Glycemic Control
Post Your Comments:
(Date:9/2/2014)... Sept. 2, 2014 Donald Spector , ... US Pat.# 8,823,512 for a Wearable Biosensor, which will ... portfolio in this field.  Mr. Spector holds some of ... announcement was made today by New York College of ... a powerhouse of world-class intellectual properties.  New York College ...
(Date:9/2/2014)...  Edison Nation Medical, the premier healthcare innovation ... Association for Respiratory Care ( AARC ), the ... Nation Medical, which brings 12+ years experience working ... innovation ideas, will work with AARC to assist ... respiratory therapists in bringing their product innovation ideas ...
(Date:9/2/2014)... 2014 /PRNewswire-iReach/ -- The Australian healthcare market is ... and good access to facilities such as government-subsidized ... disease burden, well-defined regulatory guidelines, the usage of ... manufacturing policy will drive the growth of the ... generic substitution and price cuts will restrict the ...
Breaking Medicine Technology:Wearable Biosensor Patent, the Grandfather of Wearable Biosensor Transmission Patents, Granted to Donald Spector, One of the Most Prolific Living Inventors in the World 2Wearable Biosensor Patent, the Grandfather of Wearable Biosensor Transmission Patents, Granted to Donald Spector, One of the Most Prolific Living Inventors in the World 3Wearable Biosensor Patent, the Grandfather of Wearable Biosensor Transmission Patents, Granted to Donald Spector, One of the Most Prolific Living Inventors in the World 4Wearable Biosensor Patent, the Grandfather of Wearable Biosensor Transmission Patents, Granted to Donald Spector, One of the Most Prolific Living Inventors in the World 5Edison Nation Medical and AARC Team Up To Promote Innovation in Respiratory Care 2Edison Nation Medical and AARC Team Up To Promote Innovation in Respiratory Care 3Australia Medical Devices Market worth $10.4 billion by 2020 Says a New Report Available at MarketOptimizer.org 2Australia Medical Devices Market worth $10.4 billion by 2020 Says a New Report Available at MarketOptimizer.org 3Australia Medical Devices Market worth $10.4 billion by 2020 Says a New Report Available at MarketOptimizer.org 4Australia Medical Devices Market worth $10.4 billion by 2020 Says a New Report Available at MarketOptimizer.org 5
... Wash., Oct. 13, 2011 Sterling Health Plans announces ... health insurance plans get the best results from their ... program (MTM), is managed by Outcomes Pharmaceutical Health Care® ... MTM program is designed to prevent potential drug complications ...
... (NYSE: DGX ), the world,s leading provider of ... report third quarter 2011 results on Tuesday, October 25, before ... with investors to discuss the results beginning at 8:30 a.m. ... the conference call through a live audio webcast available on ...
Cached Medicine Technology:Sterling Health Plans Announces Medication Therapy Management Program Partnership 2Quest Diagnostics to Release Third Quarter 2011 Financial Results 2
(Date:9/2/2014)... September 03, 2014 Recently, Top ... hosting companies and announced that JustHost ( http://www.justhost.com/track/seohosts ... the webmasters. , “The hosting suppliers we recommend ... their competitors on hosting features, uptime and server ... 10 Best SEO Hosting says. “We believe that ...
(Date:9/2/2014)... 02, 2014 The use of Xarelto ... is growing at a rapid pace, even as ... courts around the U.S., Bernstein Liebhard LLP reports. According ... Medicine, within a year of its 2011 launch, patients ... warfarin, a blood thinner that has been in use ...
(Date:9/2/2014)... breast cancer in California, the percentage undergoing a double ... procedure was not associated with a lower risk of ... study in the September 3 issue of JAMA ... removal of one breast was associated with a higher ... the study. , Randomized trials have demonstrated similar survival ...
(Date:9/2/2014)... The Dream2Walk Foundation along with Gas Monkey Bar and Grill ... Cord Injury Awareness Month featuring full band performances by Zane ... Automotive will be there hosting a Hot Rod, Rat Rod, ... The car show is Pre 1964 only, with a $50.00 ... There will be trophies for top 3 and best of ...
(Date:9/2/2014)... supplements did not reduce delirium in seniors who had ... Many older hospital patients experience the sudden, severe confusion ... sleep-wake cycle. A lack of the hormone melatonin may ... has been little research into whether melatonin supplements would ... average age 84, who had hip fracture surgery. About ...
Breaking Medicine News(10 mins):Health News:Xarelto Lawsuit News: Bernstein Liebhard LLP Comments on Growing Use of Xarelto in Spite of Mounting Product Liability Litigation 2Health News:Xarelto Lawsuit News: Bernstein Liebhard LLP Comments on Growing Use of Xarelto in Spite of Mounting Product Liability Litigation 3Health News:Xarelto Lawsuit News: Bernstein Liebhard LLP Comments on Growing Use of Xarelto in Spite of Mounting Product Liability Litigation 4Health News:Increase seen in use of double mastectomy 2Health News:Increase seen in use of double mastectomy 3Health News:Gas Monkey Hosts Concert in Dallas Benefiting Dream2Walk Foundation with Linear Automotive 2
... HEIGHTS, N.J., May 2 Authentidate,Holding Corp. (Nasdaq: ... workflow,management software and web-based services, today announced the ... on Friday, May 2,2008, at the Grand Hyatt ... election of the following individuals to,serve on Authentidate,s ...
... Inc.,(Nasdaq: OSTE ) announces today that on April ... response to its notification to Nasdaq that,Robert W. Gunn, ... of,Directors, Audit and Compensation Committees, passed away unexpectedly on,April ... independent directors,serving on its Audit Committee and is not ...
... ATLANTA, May 2 Now in its 11th year ... cancer research, Georgia Power,s Run for,the Reason relay team ... and support the American Cancer Society. This year,s relay ... Georgia Power president and,CEO who passed away from cancer ...
... On the eve of the British Columbia inquiry into the ... CMAJ (Canadian Medical Association Journal) finds that in some cases, ... evidence is contrary to current views that stun guns only ... the pulses generated by stun guns are designed to incapacitate ...
... Properties, Inc.,s (NYSE: NHP ) Board of Directors declared ... that will be paid on,June 6, 2008 to shareholders of ... of Directors declared cash dividends of,$1.9375 per share on its ... be paid on June 30, 2008 to stockholders of,record on ...
... 2 Hill-Rom Holdings,Inc., (NYSE: HRC ) invites ... president and chief executive officer, Hill-Rom. He will be,speaking ... Las Vegas on,Thursday, May 15, 2008 at 9:10 a.m. ... listen to the live presentation via the internet,link at ...
Cached Medicine News:Health News:Authentidate Holding Corp. Announces Results From Annual Meeting of Stockholders 2Health News:Authentidate Holding Corp. Announces Results From Annual Meeting of Stockholders 3Health News:Osteotech Announces the Unexpected Passing of Audit Committee Member Leads to Receipt of Nasdaq Deficiency Letter 2Health News:Relay Team Runs to Raise Funds for the American Cancer Society 2Health News:Evidence that stun guns may stimulate the heart 2Health News:NHP Declares Its Quarterly Cash Dividends on Common Stock and Series B Preferred Stock 2Health News:NHP Declares Its Quarterly Cash Dividends on Common Stock and Series B Preferred Stock 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: