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Preclinical Data on Cytogen's Technology to be Reported at the AACR,Annual Meeting

active-transport peptides derived from phage libraries. The abstracts are available and can be viewed on-line at no charge through the AACR website at http://www.aacr.org, which is not part of this press release.

About Antigen-Binding peptides or Abtides(TM)

AxCell has developed Abtides; small, highly specific peptides, 38-43 amino acids in length, obtained from its novel phage libraries. Their small size, specific target recognition, high affinity and cost-efficient one-step chemical synthesis make them ideal as therapeutic and/or imaging agents and provide valuable advantages over other targeting agents, such as monoclonal antibodies. AxCell has already produced Abtides that target prostate-specific membrane antigen (PSMA) on prostate cancer cells and MUC-1, a tumor antigen expressed in breast, pancreatic and ovarian cancers. Other Abtides with specificity for EGFR-positive tumors are also being investigated.

About Oral Drug Delivery Technology

AxCell has also developed oral drug delivery agents - random peptide compositions that bind to gastro-intestinal tract (GIT) transporter proteins. These oral delivery agents are capable of facilitating transport of an active agent from the lumenal side of the GIT into the systemic blood system, and/or in targeting active agents to the GIT. By binding (covalently or noncovalently) these oral delivery agents to a drug or by coating the surface of nanoparticles or liposomes with these delivery agents, drugs can be targeted to specific receptor sites or transport pathways known to operate in the human gastrointestinal tract, thus facilitating its systemic absorption into the bloodstream. The binding of these oral delivery agents to GIT receptors has been confirmed in preclinical models, and successful in vivo delivery of nanoparticle-encapsulated insulin and leuprolide in animal models has been demonstrated.

About Cytogen

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