Navigation Links
Prana Biotechnology Presents New Key Findings on PBT2

ker protein synaptophysin.

The amyloid plaques which are the main pathological feature of the brains of Alzheimer's sufferers are composed of aggregates of the Abeta protein. The Alzheimer's research community largely supports the hypothesis that small, soluble, mobile aggregates (oligomers) of the Abeta protein are the cause of neurotoxicity in AD. PBT2's ability to inhibit the generation and toxicity of these oligomers, as well as preventing the hyperphosphorylation of tau, while improving cognition, supports the disease modifying potential of PBT2 and other drugs in the Prana development pipeline.

Geoffrey Kempler, Chairman and Chief Executive Officer of Prana commented: "The results of these studies are encouraging and lend further support to the theories driving development of PBT2. We continue to improve our understanding of PBT2's functionality and potential for disease modification as we move forward with formal clinical development. The ongoing PBT2 Phase IIa trial in early Alzheimer's patients is on track to complete dosing by the end of this year and report early in 2008."

The technique of in vivo brain microdialysis recently adopted as a research tool by Prana scientists provides a unique insight into a dynamic metabolic process, allowing researchers to sample secretions from the brains of conscious, unrestrained test animals freely interacting with their environment. Sampling from the brains of genetically-engineered AD mouse models which have received single or sequential oral doses of PBT2, it was found that the drug exerts its inhibitory effects upon the target molecule, Abeta, rapidly and reproducibly without causing "rebound" effects observed with other drugs in development. Most particularly, a dramatic reduction was observed in soluble oligomers of the size range identified in the literature as the most toxic form of Abeta amyloid in AD.

The findings of these studies confirm and expand upon data presented by the Compan
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Generex Biotechnology to Make Presentations At 46th Annual Meeting of the European Society of Pediatric Endocrinology
2. Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at ESMO Conference
3. Cytos Biotechnology Reports Results from Phase IIa Study with CYT003-QbG10 in Patients Suffering from Atopic Dermatitis
4. Beike Biotechnology Study Suggests Adult Stem Cells Show Promise for Peripheral Vascular Disease
5. Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at ASCO Annual Meeting
6. Generex Biotechnology Vaccine Strategy Presented at International Conference in London
7. Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at AUA Annual Meeting
8. Cougar Biotechnology Presents Positive CB7630 Clinical Data at AACR Annual Meeting Late-Breaking Clinical Trials Session
9. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
10. European Society for Medical Oncology (ESMO) Presents Data from the Clinical Trial of MediGenes Cancer-Killing Virus in Press Conference
11. Cytogen Presents Phase 1 Data Showing Promising Antitumor Activity and Safety Profile of Quadramet at International Myeloma Workshop
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Prana Biotechnology Presents New Key Findings PBT2
(Date:3/4/2015)... MARLTON, N.J. , March 4, 2015 ... brand protection and serialization solutions, announced it will be ... Roosevelt Paper. The live event, "How to Boost Manufacturing ... on Wednesday, March 18th at 2:00 PM EDT.  ... Officer for Acsis, and John Gordon , Chief ...
(Date:3/4/2015)... 4, 2015 UPM Pharmaceuticals, a division of ... Sprout Pharmaceuticals to manufacture Flibanserin 100 mg tablets. Sprout ... the first drug approved to treat hypoactive sexual desire ... dysfunction. The tablets will be manufactured at ... Tennessee . Dr. John M. ...
(Date:3/4/2015)... -- Results of the recent study, Results From a ... Positive Margin Detection , were presented as part of ... Annual Miami Breast Cancer Conference last week. ... MD, FACS, Professor of Surgery at the Sackler School ... of MarginProbe,s efficiency and accuracy when used consecutively to ...
Breaking Medicine Technology:UPM Pharmaceuticals to Manufacture Sprout Pharmaceuticals' Flibanserin Tablets 2UPM Pharmaceuticals to Manufacture Sprout Pharmaceuticals' Flibanserin Tablets 3New Study Shows Breast Re-excision Rates Significantly Reduced in 100 Consecutive Cases 2
... Valley Technologies, Inc. (LVT) is pleased to announce ... the U.S. Food and Drug Administration (FDA).  On ... with no Form 483 observations and no discussion ... relating to cGMP (current Good Manufacturing Practices).  Additionally, ...
... MORRISVILLE, N.C., Jan. 9, 2012  nContact, Inc., the ... its technology will be presented by physicians in ... Atrial Fibrillation Symposium, January 12-14 in Boston, Massachusetts. ... with VisiTrax® and next generation EPi-Sense™ Coagulation System ...
Cached Medicine Technology:nContact's Cardiac Ablation Technology to be Presented in Two Noteworthy Posters at Boston Atrial Fibrillation Symposium 2012 2
(Date:3/4/2015)... Optrix by Body Glove ” was featured on NewsWatch ... a look at the latest and coolest technology products ... reporter for NewsWatch and a technology expert, conducted the ... an ultra-rugged, waterproof case with an interchangeable lens system. ... the Consumer Electronics Show in Las Vegas every year. ...
(Date:3/4/2015)... As seen on Advanced Fertility ... be a painful condition in which the lining of ... uterus leading to very unpleasant symptoms and complications that ... a terrible effect on women’s quality of life due ... common cause of infertility in women and carries a ...
(Date:3/4/2015)... Estates, CA (PRWEB) March 04, 2015 ... clever dialogue and lyrical music, will be performed by ... Rolling Hills Estates, CA, this March 6-22, 2015, on ... Arts Center at Peninsula High School (27118 Silver ... available one hour before the program or may be ...
(Date:3/4/2015)... Wis. (PRWEB) March 04, 2015 Organic Valley, ... organic brand, today announced its cause campaign to Save the ... viral and is making a difference to Bros everywhere. ... on Youtube and Facebook. The video was named Adweek’s ... featured in Forbes, Mashable and Digiday, among other media outlets. ...
(Date:3/4/2015)... RapidScale, a global cloud services innovator, is ... March 16th-18th. They are hosting Booth #1010 on the ... top engineering executives in attendance to provide demos and ... Attendees include William Hiatt, CTO; Jeff Richards, Cloud Delivery ... Cloud Support Manager. , RapidScale is also hosting ...
Breaking Medicine News(10 mins):Health News:A Waterproof Phone Case with an Interchangeable Lens System was Featured on NewsWatch Television on January 30, 2015 2Health News:Advanced Fertility Center of Texas Brings Awareness to the Month of March-Endometriosis Awareness Month 2Health News:Advanced Fertility Center of Texas Brings Awareness to the Month of March-Endometriosis Awareness Month 3Health News:The New Mel Brooks Musical Young Frankenstein Performance March 6-March 22, 2015, by the Award Winning Drama Department at Peninsula High School, Rolling Hills 2Health News:ORGANIC VALLEY URGES PUBLIC TO SAVE THE BROs: CAMPAIGN EARNS MORE THAN 1M VIEWS ON YOUTUBE 2Health News:ORGANIC VALLEY URGES PUBLIC TO SAVE THE BROs: CAMPAIGN EARNS MORE THAN 1M VIEWS ON YOUTUBE 3Health News:Rapidscale to Host First Cloudtalk Events at Channel Partners in Las Vegas 2Health News:Rapidscale to Host First Cloudtalk Events at Channel Partners in Las Vegas 3
... OAKLAND, Calif., July 9 Members of SEIU UHW ... outside the Oakland Federal Building, 1301 Clay Street, to release newly ... former top union officials were advised by their attorney that some ... and then followed their lawyer,s advice on how to cover them ...
... woes, infertility, researchers note , THURSDAY, July 9 (HealthDay ... to the one in 10 women of childbearing age ... ovarian syndrome (PCOS). , Women with the ... testosterone -- and often develop ovarian cysts, irregular menstrual ...
... of cardiac CT for low-risk chest pain patients in the ... workup, may reduce a patients length of stay and hospital ... Washington School of Medicine, Seattle, WA. The SOC workup, which ... enzyme tests, ECGs and nuclear stress testing. , , ...
... ... Hospital in Taos, N.M., one of five winners of its 2009 NOVA Award. , ... Brentwood, Tenn. (PRWEB) July 9, 2009-- ... Holy Cross Hospital in Taos, N.M., one of five winners of its 2009 ...
... , HONOLULU, July 9 Specialty care physicians can ... health records and proactively providing e-consultations and treatment plan ... Permanente paper published online in the British Medical ... project at Kaiser Permanente demonstrated that specialists can take ...
... on innovative technologies and enhanced caregiver training , ... of America (AFA), New York, NY, and Samarion Inc., ... strategic partnership to address the critical need for optimal ... enhanced training programs for healthcare professionals. , , ...
Cached Medicine News:Health News:Newly Obtained Information Shows That Ousted Union Leaders Plotted and Covered Up Wrongdoing 2Health News:Acupuncture, Exercise May Ease Polycystic Ovarian Syndrome 2Health News:QHR Client Hospital Holy Cross Hospital Named Recipient of American Hospital Association 2009 NOVA Award 2Health News:Kaiser Permanente Project Proves Electronic Health Information and Care Coordination Improves Chronic Disease Management 2Health News:Kaiser Permanente Project Proves Electronic Health Information and Care Coordination Improves Chronic Disease Management 3Health News:Kaiser Permanente Project Proves Electronic Health Information and Care Coordination Improves Chronic Disease Management 4Health News:Alzheimer's Foundation of America and Samarion(SM) Form Strategic Alliance to Enhance Care for Individuals with Dementia 2Health News:Alzheimer's Foundation of America and Samarion(SM) Form Strategic Alliance to Enhance Care for Individuals with Dementia 3
... system represents a breakthrough for patients experiencing ... The system gathers bone during decompression, bone ... bone into the implant's chamber produces a ... from the iliac crest. The BAK/C implant ...
Intera 3.0T is the most compact high-field clinical whole-body MR system in the world, bringing 3.0T capabilities "out of the tunnel" and into the light of an open, patient-friendly design....
... Intradiscal Instruments are designed to provide ... aid in disc removal, endplate preparation, ... set consists of several Vertebral Spreaders, ... and a Vertebral Body Positioner. Used ...
... Platelet Concentrate System is a point-of-care system ... Concentrate (also referred to as Platelet Rich ... (PPP) from a small sample of blood. ... natural growth factors, which are found in ...
Medicine Products: