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Poster on Cyclosert Drug Delivery Presented at AACR Meeting

Novel System May Provide Cancer Patients With Improved Potential to Battle Their Disease

PASADENA, Calif., April 16, 2007 /PRNewswire/ -- Insert Therapeutics, Inc., a majority-owned subsidiary of Arrowhead Research Corporation announced today its novel delivery system called Cyclosert(TM) will be featured in a poster presentation at the 2007 American Association for Cancer Research (AACR) Annual Meeting. In particular, this poster includes new research findings on a promising anticancer therapy that is currently under development.

Cyclosert is the first nanoparticle drug transport platform to be designed de novo and synthesized specifically to overcome limitations in existing technologies used for the systemic transport of therapeutics to targeted sites within the body. Based on small cyclic repeating molecules of glucose called cyclodextrins, Cyclosert promotes the ability of cytotoxic drugs to inhibit the growth of human cancer cells while remaining non-toxic and non-immunogenic at therapeutic doses. In particular, the system is designed to keep the drugs non-toxic until they actually reach the targeted tumor cells where the active drug is released in a controlled fashion.

The investigational drug discussed in the research, which Insert Therapeutics is developing in collaboration with German-based R&D Biopharmaceuticals, uses the Cyclosert system to deliver a potent anticancer agent called tubulysin A. Tubulysin A is a naturally occurring substance produced by myxobacteria. It is highly active against many types of cancer cells, targeting the cellular structures called microtubules, which play a crucial role in cell division. Used by itself, tubulysin A is an effective antitumor agent, but it is also highly toxic. By combining it with the Cyclosert transport system, researchers are aiming to make it non-toxic while preserving its antitumor activity.

In vitro studies showed the tubulys
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