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Positive results from placebo-controlled phase IIa study in,patients suffering from house dust mite allergy

an organism.
Desensitization: conventional immunotherapy applied to treat allergies. Requires frequent injections (50-80 injections) of allergen under
the skin over several years.
Double-blind: a set-up often applied in clinical trials where neither the doctor nor the patient knows if placebo or the active drug
substance is applied.
Formulation: the method and process of selecting the components of a mixture. For drugs the term usually describes the way the drug is
prepared.
House dust mite allergen extract: a mixture of allergenic components from house dust mites.
Immunotherapeutic: a product aimed at activation of the immune system to modify and interfere with a certain disease process.
Median: a term used in the statistical analysis of a set of numbers; relates to or constitutes the middle value in a distribution. 50% of the
values are above and 50% below the median.
Monotherapy: treatment with one drug as opposed to combination therapy. Here the term refers to treatment with CYT003-QbG10 alone in
contrast to a regimen where CYT003-QbG10 is combined to an allergen extract (i.e. CYT005-AllQbG10).
Open-label: a set-up used in clinical trials where the doctor and the patient know what substance is administered; in contrast to e.g.
double-blind, placebo-controlled studies, where neither the doctor nor the patient have this knowledge.
Phase IIa: a clinical trial that examines a new drug candidate’s safety and exploratory efficacy and may include between 10 and 100
patients.
Placebo: dummy medical treatment.
QbG10: Cytos Biotechnology’s Immunodrug™ Qb filled with the immunostimulatory DNA sequence G10.
Randomized: random assignation of clinical trial participants to different treatment groups.
Th1 and Th2 type immune responses: describe T helper cell responses. T helper cells are a subset of T cells that secrete a variety of
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