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Positive results from placebo-controlled phase IIa study in,patients suffering from house dust mite allergy

logy AG
Cytos Biotechnology AG is a public Swiss biotechnology company that specializes in the discovery, development
and commercialization of a new class of biopharmaceutical products – the ImmunodrugsTM. ImmunodrugsTM are
intended for use in the treatment and prevention of common chronic diseases, which afflict millions of people
worldwide. ImmunodrugsTM are designed to instruct the patient’s immune system to produce desired therapeutic
antibody or T cell responses that modulate chronic disease processes. Taking advantage of the high flexibility of its
ImmunodrugTM platform, Cytos Biotechnology has built a pipeline of different ImmunodrugTM candidates in various
disease areas, of which 6 are currently in clinical development. The ImmunodrugTM candidates are developed both
in-house and together with Novartis and Pfizer Animal Health. Founded in 1995 as a spin-off from the Swiss
Federal Institute of Technology (ETH) in Zurich, the company is located in Schlieren (Zurich). Currently, the
company has 130 employees. Cytos Biotechnology AG has been listed on the SWX Swiss Exchange (SWX:CYTN) since
October 2002.

Glossary
Allergen tolerance: non-reactivity to a certain allergen or reactivity only up to the level of a predefined minimal symptom score.
Allergic rhinitis: a condition due to allergy that mimics a cold. Rhinitis means "inflammation of the nasal mucous membranes".
Atopic dermatitis: a chronic skin disease; a certain type of eczema. Is accompanied by an inherited tendency to develop allergic diseases.
Conjunctival provocation test: a commonly used allergy test to monitor the allergic disease status of an individual.
Disease-modifying: in contrast to symptomatic treatment, a disease-modifying treatment aims at addressing the cause of disease and to
modify disease progression.

DNA: deoxyribonucleic acid; genetic information of
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