( r />and female patients aged 18 to 65 ...)Positive results from placebo-controlled phase IIa study in,patients suffering from house dust mite allergy,Health

r /> and female patients aged 18 to 65 and suffering from mild to moderate perennial allergic rhinitis due
to house dust mite allergy. Upon entry into the study, the allergic status of the individual
participants was recorded by the conjunctival provocation test, a commonly used allergy test. The
study participants were randomized into 4 treatment groups with 10 patients each and received 6
weekly subcutaneous injections of either i) 300 ?g CYT003-QbG10 alone, ii) 300 ?g CYT003-QbG10
plus a low dose of house dust mite allergen extract (designated CYT005-AllQbG10), iii) a low dose of
house dust mite allergen extract alone, or iv) placebo. The house dust mite allergen dose
administered in treatment arms ii) and iii) was 10-times lower than that usually applied in
conventional desensitization therapy. Two weeks after the last dose, the allergic status of the
patients was again assessed by the conjunctival provocation test, which served as the primary
efficacy parameter of the study. All 40 patients were included into the analysis.

About CYT003-QbG10
CYT003-QbG10 is an immunotherapeutic product in development for the treatment of allergy, asthma
and atopic dermatitis. It consists of the ImmunodrugTM QbG10 which is comprised of the virus-like
particle Qb filled with a synthetic immunostimulatory DNA sequence called G10. CYT003-QbG10 is
designed as a disease-modifying treatment and aims to induce a potent Th1 type immune response
in order to suppress an “allergic” Th2 type immune response. An earlier, open-label phase IIa study
with CYT003-QbG10 combined with an allergen extract of house dust mites at a standard dose
showed excellent long-term efficacy in patients allergic to dust mites. Furthermore, a placebocontrolled
phase IIa study with CYT003-QbG10 showed significant improvement of allergy symptoms
in hay fever patients. CYT003-Qb
'"/>




Page: 1 2 3 4 5 6 7
Related medicine technology :

1. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
2. Positive Aggrastat Results Featured in the Journal of the American College of Cardiology
3. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
4. Protox Announces Positive Clinical Data from Prostate Cancer Study
5. AM-Pharma Announces Positive Results of Phase IIa Clinical Trial with Alkaline Phosphatase For Ulcerative Colitis
6. Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at ESMO Conference
7. TransPharma Medical Announces Positive Results of Phase I Clinical Trials for Transdermal Delivery of hPTH (1-34) for Osteoporosis Treatment
8. Positive ZIO-201 Interim Phase II Sarcoma Data Presented at European Society for Medical Oncology
9. Cosmo Pharmaceuticals Reports Positive Preliminary Phase II/III Data with Rifamycin MMX in Infectious Diarrhea
10. Portola Pharmaceuticals Announces Positive Phase II EXPERT Results and Additional Oral and Poster Presentations at the XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH)
11. Chi-Med Announces Positive Phase II Proof-of-Concept Data for HMPL-004 in Ulcerative Colitis