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Positive results from placebo-controlled phase IIa study in,patients suffering from house dust mite allergy

Cytos Biotechnology reports positive results from placebo controlled phase IIa study in patients suffering from house dust mite allergy

SCHLIEREN (Zurich), Switzerland, May 15, 2007 - Cytos Biotechnology AG (SWX:CYTN) reported today positive results from a multi-centre and placebo-controlled phase IIa study with different formulations of CYT003-QbG10, an immunotherapeutic product candidate for the treatment of allergic diseases. The study included 40 patients suffering from mild to moderate allergic rhinitis due to house dust mite allergy and assessed in a double-blind setting the safety, tolerability and exploratory efficacy of CYT003-QbG10 monotherapy, CYT003-QbG10 combined with a low dose of house dust mite allergen extract (designated CYT005-AllQbG10), allergen extract alone and placebo. Exploratory efficacy was determined by evaluating the allergic disease status of the patients before and after treatment by the conjunctival provocation test.

Both formulations of CYT003-QbG10 tested were safe and well tolerated. The table below summarizes
on the first results obtained two weeks after the last dose. A statistically significant increase in the
median allergen tolerance against baseline was observed only in the two treatment arms which
comprised QbG10 (i.e. CYT003-QbG10 monotherapy and CYT005-AllQbG10), whereas none of the
intergroup comparisons achieved statistical significance.

CYT003-QbG10
n=10
CYT005-AllQbG10
n=10
Placebo
n=10
Allergen
n=10
Increase of median
allergen tolerance
against baseline
factor of 10
factor of 10
factor of 1
factor of 10
p-value <0.05 <0.05 n.s. n.s.

Dr. Wolfgang Renner, CEO of Cytos Biotechnology commented: “With each study we gain a deeper
understanding of the activity of QbG10 in allergic diseases. If we look at the entire data set of the
80 allergic pa
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