igue, headache, joint pain, cough,
dizziness, dyspepsia and dyspnea, dermatitis, eczema, fluid
retention, as well as neutropenia, thrombocytopenia and anemia.
Glivec was generally well-tolerated in all of the studies that were
performed, either as monotherapy or in combination with
chemotherapy, with the exception of a transient liver toxicity in
the form of transaminase elevation and hyperbilirubimaemia observed
when Glivec was combined with high dose chemotherapy.
Patients with cardiac disease or risk factors for cardiac
failure should be monitored carefully and any patient with signs or
symptoms consistent with cardiac failure should be evaluated and
treated. Cardiac screening should be considered in patients with
HES/CEL, and patients with MDS/MPD or SM with high level of
eosinophils (echocardiogram, serum troponin level).
Rare/serious adverse reactions include: sepsis, pneumonia,
depression, convulsions, cardiac failure, thrombosis/embolism,
ileus, pancreatitis, hepatic failure, exfoliative dermatitis,
angioedema, Stevens-Johnson syndrome, renal failure, fluid
retention, edema (including brain, eye, pericardium, abdomen and
lung), hemorrhage (including brain, eye, kidney and
gastrointestinal tract), diverticulitis, gastrointestinal
perforation, tumour hemorrhage/ necrosis, hip
osteonecrosis/avascular necrosis.
Glivec is contraindicated in patients with known
hypersensitivity to imatinib or any of its excipients. Women of
childbearing potential should be advised to avoid becoming pregnant
while taking Glivec.
Disclaimer The foregoing release contains forward-looking
statements that can be identified by terminology such as "will,"
"planned," or similar expressions, or by express or implied
discussions regarding potential future regulatory submissions, new
indications or new labeling for Glivec, the long-term impact of a
patient's use of Glivec or potential future sales of Glivec. Such
forward-looking statements involve known and unknow
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