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Positive Final Data from HyCAMP Phase II Trial in Metastatic,Colorectal

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    ENQUIRIES:

    Dr Pete Smith

    Alchemia Limited Chief Executive Officer

    Tel: +61-7-3340-0200


    RELEASED BY:

    Mr Geoff Breusch

    Phillips Group

    Tel: +61-7-3230-5000
 

About HyACT(TM)

HyACT(TM) is a proprietary technology which utilises hyaluronic acid (HA), to deliver and enhance the retention of anti-cancer drugs and biologics within tumours. The drug becomes entrained within the HA matrix and the HA binds to receptors located on the tumour cell resulting in more of the drug being delivered to the tumour. Preclinically, the HyACT(TM) technology has demonstrated improved delivery of drug to the tumour resulting in significantly reduced toxicity as well as increased efficacy and survival.

About Camptosar(R) (irinotecan)

Camptosar(R) is widely used in the treatment of metastatic colorectal cancer, and is being evaluated in many other tumour types. Like most cytotoxic drugs the use of Camptosar(R) is restricted by its side-effects, the most significant of which are diarrhea and neutropenia. Sales of Pfizer's Camptosar(R) were US$903 million in 2006. Patent exclusivity for the drug expires in 2008 in the US and 2009 in the EU.

Camptosar(R) is a registered trade mark of Pfizer Inc.

About HyCAMP(TM)

HyCAMP(TM) is a proprietary formulation of the anti-cancer drug Camptosar(R) with HA. Preclinical studies with HyCAMP(TM) demonstrated improved delivery of the drug to the tumour, resulting in increased efficacy and reduced toxicity. The phase II clinical trial was initiated to evaluate HyCAMP(TM) in patients with metastatic colorectal cancer.

HyACT(TM) and HyCAMP(TM) were obtained through Alchemia's acquisition of Melbourne-based oncology company Meditech Research Ltd in 2006.

This clinical study was financially supported in part by NovoZymes Biopolymer A/S.

CONTACT: Dr Pete Smith, Chief Executive Officer of Alchemia Limited,+61
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