Navigation Links
Positive Clinical Data for TASQ - Active Biotech's Novel Treatment,of Prostate Cancer

LUND, Sweden, March, 9, 2007-Active Biotech (ACTI.ST), today announced new positive clinical data from the Phase Ib study of TASQ, for the treatment of prostate cancer.

By step-wise dose escalation, a safe dose of 1 mg/day of TASQ was achieved, which corresponds to a doubling of the previously reported maximum tolerated dose (MTD) level of 0.5 mg/day. This means that a step-wise intra-patient dose-escalation enables a dose of 1 mg/day to be administered in future clinical trials.

"These new results confirm and reinforce earlier results obtained at a lower dose level. We now have a very complete data set that constitute a solid base to move into Phase II clinical trials", said Sven Andréasson, President and CEO of Active Biotech.

The ongoing 10-week study comprises patients with so called hormone-refractory prostate cancer. This is an advanced stage of prostate cancer where the tumor cells no longer respond to hormone treatment. All patients entering the study had rising serum levels of Prostate Specific Antigen (PSA), which is a surrogate marker for tumor progression.

PSA measurements were recorded and PSA velocity (PSAV) was calculated after 28 days of treatment. Five out of six patients had a >50% decrease in PSA velocity compared to prior treatment. Three of these five patients exhibited a decrease in absolute PSA levels.

The study is being performed at the urological clinics at the University Hospitals in Lund, Malmö and Uppsala, Sweden.

The objective of the TASQ project is to develop a pharmaceutical product that can be administered orally for the long-term treatment of prostate cancer. Phase II studies are scheduled to start during 2007. The Medical Products Agency has approved on the new MTD to be used in the continued clinical program of TASQ.

The pharmaceutical market for prostate cancer is estimated at more than USD 3 billion a year. Prostat
'"/>




Page: 1 2

Related medicine technology :

1. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
2. Positive Aggrastat Results Featured in the Journal of the American College of Cardiology
3. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
4. Protox Announces Positive Clinical Data from Prostate Cancer Study
5. AM-Pharma Announces Positive Results of Phase IIa Clinical Trial with Alkaline Phosphatase For Ulcerative Colitis
6. Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at ESMO Conference
7. TransPharma Medical Announces Positive Results of Phase I Clinical Trials for Transdermal Delivery of hPTH (1-34) for Osteoporosis Treatment
8. Positive ZIO-201 Interim Phase II Sarcoma Data Presented at European Society for Medical Oncology
9. Cosmo Pharmaceuticals Reports Positive Preliminary Phase II/III Data with Rifamycin MMX in Infectious Diarrhea
10. Portola Pharmaceuticals Announces Positive Phase II EXPERT Results and Additional Oral and Poster Presentations at the XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH)
11. Chi-Med Announces Positive Phase II Proof-of-Concept Data for HMPL-004 in Ulcerative Colitis
Post Your Comments:
(Date:9/22/2014)... September 22, 2014 Final ... 25   The second edition of the ... excited to announce the final nominations for the 2014 ... on the evening of September 25 at The Taj Mahal Palace, ... applicants based on a variety of qualitative and quantitative ...
(Date:9/22/2014)... Sept. 22, 2014  Elusys Therapeutics, Inc. (Elusys), ... infectious disease, today announced it has completed three ... obiltoxaximab (ETI-204). Obiltoxaximab is an anti-toxin in development ... from these studies support the safety and tolerability ... the intended therapeutic dose. The conclusion of these ...
(Date:9/22/2014)... , Sept. 22, 2014  Aethlon Medical, ... therapeutic devices to address infectious disease, cancer and ... Advanced Research Projects Agency (DARPA) has informed the ... to proceed with year four of a five-year ... on September 30, 2011 under DARPA,s Dialysis-Like Therapeutics ...
Breaking Medicine Technology:Recognising Impactful Healthcare Companies at VCCircle Healthcare Awards 2014 2Recognising Impactful Healthcare Companies at VCCircle Healthcare Awards 2014 3Elusys Announces Results From Three Phase 3 Safety Studies Of Its Anthrax Anti-Toxin, Obiltoxaximab (ETI-204), In Adult Volunteers And Completion Of Its Phase 3 Clinical Development Program 2Elusys Announces Results From Three Phase 3 Safety Studies Of Its Anthrax Anti-Toxin, Obiltoxaximab (ETI-204), In Adult Volunteers And Completion Of Its Phase 3 Clinical Development Program 3Elusys Announces Results From Three Phase 3 Safety Studies Of Its Anthrax Anti-Toxin, Obiltoxaximab (ETI-204), In Adult Volunteers And Completion Of Its Phase 3 Clinical Development Program 4Elusys Announces Results From Three Phase 3 Safety Studies Of Its Anthrax Anti-Toxin, Obiltoxaximab (ETI-204), In Adult Volunteers And Completion Of Its Phase 3 Clinical Development Program 5Elusys Announces Results From Three Phase 3 Safety Studies Of Its Anthrax Anti-Toxin, Obiltoxaximab (ETI-204), In Adult Volunteers And Completion Of Its Phase 3 Clinical Development Program 6Aethlon Medical Receives Notice of DARPA Contract Renewal 2Aethlon Medical Receives Notice of DARPA Contract Renewal 3Aethlon Medical Receives Notice of DARPA Contract Renewal 4
(Date:9/22/2014)... Alan Mozes HealthDay ... Pediatricians, take note: Many American parents are aware of online ... choose a pediatrician for their children, according to a new ... more than 1,600 parents -- further suggest that negative online ... that doctor has been recommended by a neighbor. Conversely, ...
(Date:9/22/2014)... a whole eye transplant seems futuristic, if not ... U.S. Department of Defense, researchers at University of ... someday make implantation of an entire, functional eye ... be a holy grail for vision restoration," said ... grant co-recipient with colleagues at University of Pittsburg ...
(Date:9/22/2014)... have found that an anticonvulsant drug may help in ... dozens of antibiotics target what bacteria do, their study ... are created, and they found there is a way ... as there is growing concern worldwide about how antibiotic ... World Health Organization has declared that antibiotic resistance is ...
(Date:9/22/2014)... 22, 2014 An inventor and anesthesiologist ... the problem of side-sleeping. "My lower arm always became ... designed a solution to this problem," she said. "It’s ... to have your arm 'fall asleep.'" , The Sleeping ... her side more comfortably. It avoids pain and restlessness ...
(Date:9/22/2014)... 2014 -- Recent two-generation approaches to reducing poverty ... increasing attention from researchers, advocates, and foundations. By ... them to move to jobs that offer a ... and education for children, these programs aim to ... according to a new report from the National ...
Breaking Medicine News(10 mins):Health News:Many Parents Use Online Ratings to Pick a Pediatrician, Study Finds 2Health News:Many Parents Use Online Ratings to Pick a Pediatrician, Study Finds 3Health News:Looking ahead: Whole eye transplant under development 2Health News:A two-generation lens: Current state policies fail to support families with young children 2
... WashingtonThe American College of Physicians (ACP) today applauded Rep. ... for their bipartisan introduction of the Medicare Physician Payment ... is designed to eliminate the flawed Sustainable Growth Rate ... scheduled cuts. The SGR cuts threaten to drive physicians ...
... Black Americans who suffer cardiac arrest in public places are ... automated external defibrillators, a new study has found. Cardiac ... to stop beating. CPR and automated external defibrillators (AEDs) -- ... a normal rhythm -- can help a cardiac arrest victim ...
... May 11 (HealthDay News) -- Heart attack survivors are more ... it,s safe, a new study shows. University of Chicago ... study. Among patients who were sexually active before their heart ... discharged from the hospital were 1.5 times more likely to ...
... Brophy Marcus HealthDay Reporter , FRIDAY, May ... their periods, but new research suggests weight-loss surgery can ... hair growth and skin problems that often accompany significant ... the United States," said study author Chandhana Paka, a ...
... mobility now have access to specialized exercise equipment in ... the University of Alberta and the Spinal Cord Injury ... electrical stimulation (FES) rehabilitation therapy machines are now available ... Faculty of Physical Education and Recreation at the U ...
... disease allow physicians to tailor treatment to a patient,s ... many types of cancer the molecular subtypes are more ... that can affect a patient,s response to therapy. ... the first time that lung cancer molecular subtypes correlate ...
Cached Medicine News:Health News:ACP applauds introduction of bipartisan bill to eliminate Medicare SGR formula 2Health News:Blacks Less Likely to Get Help on Scene After Cardiac Arrest: Study 2Health News:Blacks Less Likely to Get Help on Scene After Cardiac Arrest: Study 3Health News:Sex After Heart Attack? Doc's OK May Be Key 2Health News:Weight-Loss Surgery May Also Help Menstruation, Skin, Hair 2Health News:Weight-Loss Surgery May Also Help Menstruation, Skin, Hair 3Health News:Partnership provides inclusive workout 2Health News:Partnership provides inclusive workout 3Health News:Molecular subtypes and genetic alterations may determine response to lung cancer therapy 2
... innovative stent allows the physician to intubate the ... with just topical anesthetic drops., ,The SRS is ... in three lengths 25mm, 30mm and 35mm (disposable ... stent is an anchor-shaped head to provide fixation. ...
... or somatomedin-C, is a peptide highly dependent ... promoting activity. IGF-I is transported in serum ... of growth disorders, measurements of IGF-I are ... hormone secretion. A normal plasma or serum ...
... is a high-throughput immunoassay system built around ... 2000 with the important addition of Logic ... to be designed for optimal performance with ... for critical assays such as the cardiac ...
... For The Detection ... Uses Of C-Peptide Measurement:, ... fasting hypoglycemia , Assisting ... diabetes mellitus , Differentiating ...
Medicine Products: