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Pluristem's PLX Cells Demonstrate Potential to Treat Parkinson's,Disease

NEW YORK--(BUSINESS WIRE)--Jun 14, 2007 - Pluristem Life Systems, Inc. (OTCBB:PLRS) (DAX:PJT), a bio-therapeutics Company dedicated to the commercialization of products for a variety of malignant, degenerative and auto-immune indications, announced today that Pluristem's PLacenta eXpanded (PLX) cells have been demonstrated in vitro to have properties that the Company believes gives these cells the potential to treat Parkinson's Disease (PD). PLX cells are Pluristem's placental-derived mesenchymal stem cells (MSCs) that have been expanded in the Company's proprietary PluriX(TM) 3-D bioreactor.

Pluristem Chairman and CEO, Mr. Zami Aberman commented, "These preliminary results are encouraging. We intend to pursue further in vitro and in vivo studies with our PLX cells in the treatment of Parkinson's Disease as well as other disorders of the central nervous system. As a cellular therapy for PD and other neurodegenerative diseases, our PLX cells could be a readily available source of important enzymes, neurotransmitters and neurotrophic factors." Pluristem believes their future products will participate in the approximate $30 billion therapeutic and regenerative cellular market.

The in vitro assay demonstrated that Pluristem's PLX cells can be differentiated into dopaminergic neurons. These neurons were found to have properties favorable to cells, which are known to be helpful in treating PD. These properties include the expression of tyrosine hydroxylase, and the finding of elevated nurr1 mRNA levels. Additionally, these neurons were found to secrete favorable neurotrophic factors such as GDNF, BDNF, IGF-1, and astrocytes markers such as S-100-b, GLUL, and GFAP.

About Parkinson's Disease

PD is a well characterized degenerative neurological disease whose symptoms are felt to be related to damage to dopamine-producing cells in the Central Nervous System (CNS). PD is felt to currently afflict appr
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