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Placebo-controlled Phase IIa Study with the Immunotherapeutic,CYT003-QbG10 Shows Significant Improvement of Allergy Symptoms in,Hay Fever Patients

herefore, a significant unmet medical need remains for allergic disease treatment.

Glossary

Allergic rhinitis: a condition due to allergy that mimics a cold. Rhinitis means "inflammation of the nasal mucous membranes".

Alum: commonly used adjuvant in human applications. An adjuvant is administered to enhance an immune response.

Atopic dermatitis: a chronic skin disease; a certain type of eczema. Is accompanied by an inherited tendency to develop allergic diseases.

Conjunctival provocation test: a commonly used allergy test to monitor the allergic disease status of an individual.

Disease-modifying: in contrast to symptomatic treatment, a disease-modifying treatment aims at addressing the cause of disease and modifying the disease progression.

DNA: deoxyribonucleic acid; genetic information of an organism.

Double-blind: a set-up often applied in clinical trials where neither the doctor nor the patient knows if placebo or the active drug substance is applied.

Formulation: the method and process of selecting the components of a mixture. For drugs the term usually describes the way the drug is prepared.

Grass pollen extract: a mixture of allergenic components from grass pollen.

Hay fever: seasonal allergic rhinitis.

Immunotherapy / immunotherapeutic: a therapy aimed at activation of the immune system to modulate a certain disease process.

Conventional immunotherapy for allergic diseases, also termed desensitization, is performed with allergen. CYT003-QbG10 appears to act differently, namely through an allergen-independent mechanism of action in the absence of an added allergen.

Median: a term used in the statistical analysis of a set of numbers; it relates to or constitutes the middle value in a
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