Navigation Links
Pixantrone Combination Therapy for First-line Treatment of,Aggressive Non-Hodgkin's Lymphoma Results in Reduction in Severe,Toxicities Including Heart Damage When Compared to,Doxorubicin-based Therapy

phoma, and leukemia, where debilitating cardiac damage from doxorubicin might be prevented. We look forward to discussing these results and our planned interim analysis of the PIX301 (EXTEND) pivotal trial with the FDA. We believe the RAPID data coupled with the EXTEND data may provide sufficient clinical information for review of pixantrone in aggressive NHL."

Details of the RAPID Trial

The RAPID (Replacing Adriamycin with Pixantrone to Improve Safety in NHL Disease) trial is a 280-patient randomized controlled phase II/III combination study investigating whether the substitution of pixantrone for doxorubicin in the first-line treatment of patients with advanced aggressive NHL can provide a comparable major response rate while reducing known doxorubicin-related toxicities. This multi-center international trial randomizes newly diagnosed patients to either the standard of care regimen CHOP-R (cyclophosphamide, doxorubicin, vincristine, prednisone, and rituximab) or an investigational regimen which replaces doxorubicin with pixantrone, CPOP-R (cyclophosphamide, pixantrone, vincristine, prednisone, and rituximab) monthly for six cycles. Patients are evaluated for response to therapy every two cycles and evaluated every two months following completion of therapy.

Cardiac function, as determined by serial multi-gated nuclear scans (MUGA), is evaluated prior to initiation of therapy and then at the completion of every two cycles of therapy. Thus far, routine prophylactic administration of G-CSF was utilized equally across treatment arms in approximately half of study participants. The interim analysis was conducted after approximately 60 patients completed at least four cycles of therapy to determine if the dose of pixantrone (150 mg/m2) was adequate to induce major objective responses comparable to the doxorubicin arm as well as to evaluate potential differences in major toxicities.

Pixantrone in Clinical Studies

There are currently tw
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
2. Publication on Pixantrone Preclinical Studies Demonstrates Reduced Cardiotoxicity Compared to Equiactive Doses of Doxorubicin and Mitoxantrone
3. Pixantrone Granted Fast Track Designation by FDA for Relapsed Indolent NHL Patients
4. New Phase 3 Study Published in The Lancet Evaluates Efficacy and Safety of Prezista/Ritonavir vs. Kaletra as Part of HIV Combination Therapy in Treatment-Experienced Adults With HIV
5. Cyclacel Pharmaceuticals Announces Results of Phase II Seliciclib Combination Studies
6. An Investigational Study Released at ADA Showed that Initial Combination Therapy with Januvia (sitagliptin) and Metformin Led to Improvement in Markers of Beta Cell Function in Patients with Type 2 Diabetes
7. Late Breaking Data Released at ADA Showed that the Investigational Use of Januvia and Metformin as Initial Combination Therapy Provided Significant Glucose Lowering Efficacy over 54 Weeks in Patients with Type 2 Diabetes
8. Poniard Pharmaceuticals Announces Promising Data From Interim Safety Analysis of Phase 1 Combination Trials of Picoplatin in Colorectal and Prostate Cancers
9. Peregrine Pharmaceuticals Reports Positive Top-Line Results in Bavituximab Combination Therapy Trial in Advanced Cancer Patients
10. Intarcia Therapeutics Announces Presentation of Final Results From a Phase 2 Combination Study for the Treatment of Hepatitis C at the Digestive Disease Week Conference
11. Data Presented at ASH Demonstrate Nebivolol Lowers Blood Pressure as Long-Term Monotherapy and in Combination Therapy
Post Your Comments:
(Date:8/22/2014)... 22, 2014  Dr. Mark Rasak , MD ... Lifetime Achievement Award in the field of Medicine as ... Clinical Associates. Dr. Rasak has over 15 ... aspects of the business; overseeing the daily operations; interventional ... intervention. In addition, he is an honored Fellow of ...
(Date:8/22/2014)... , Aug. 22, 2014 Research and ... "Global and Chinese Particulate Respirators Industry Report 2014" ... and Chinese Particulate Respirators Industry Report 2014 is a ... the global particulate respirators industry with a focus on ... overview of the industry including definitions, classifications, applications and ...
(Date:8/22/2014)... , Aug. 22, 2014  Cannabis Science, Inc. ... formulation-based drug development and related consulting, is pleased ... international medical cannabis conference taking place at the ... , on October 22, 2014.  The multilingual ... such as researchers, health professionals, and patients, to ...
Breaking Medicine Technology:Dr. Mark Rasak, MD is recognized by Continental Who's Who with the Diamond Lifetime Achievement Award 2Global and Chinese Particulate Respirators Industry Report 2014 2Cannabis Science, Inc. (CBIS) to Sponsor 3rd International Conference on Cannabinoids in Medicine in October 2014 in Strasbourg, France 2Cannabis Science, Inc. (CBIS) to Sponsor 3rd International Conference on Cannabinoids in Medicine in October 2014 in Strasbourg, France 3
... annual open enrollment season begins for Medicare Part ... to answer questions and provide guidance on how ... December 7, Medicare beneficiaries have the opportunity to ... a new plan, if they so choose. ...
... 14, 2011 Intellect Neurosciences, Inc. (OTCBB: ILNS), a ... disease-modifying therapeutic agents for the treatment of Alzheimer,s and ... Shareholders from Dr. Daniel Chain, Chairman and CEO. ... take this opportunity to update you about pertinent corporate ...
Cached Medicine Technology:CVS/pharmacy Ready to Provide Assistance During Medicare Part D Annual Enrollment Period 2Intellect Neurosciences Issues Letter to Shareholders 2Intellect Neurosciences Issues Letter to Shareholders 3Intellect Neurosciences Issues Letter to Shareholders 4Intellect Neurosciences Issues Letter to Shareholders 5Intellect Neurosciences Issues Letter to Shareholders 6Intellect Neurosciences Issues Letter to Shareholders 7Intellect Neurosciences Issues Letter to Shareholders 8Intellect Neurosciences Issues Letter to Shareholders 9
(Date:8/22/2014)... Restore My Vision Today , a ... to help people discover how they can get rid ... instead improving their eyesight naturally has caught the attention ... “There’s a reason why the glasses and contacts industry ... people just assume that it’s their only option to ...
(Date:8/22/2014)... NJ (PRWEB) August 22, 2014 ... leading specialist in Internal Medicine, Geriatrics, Hospice and ... network, CarePoint Health Medical Group. Their system welcomes ... skilled and experienced physicians comprise CarePoint Health Medical ... practices in Hudson County, representing a wide range ...
(Date:8/22/2014)... Dayton, Ohio (PRWEB) August 22, 2014 Dayton ... patient care tower as part of a $141 million campus ... new patient care tower were unveiled to the public. ... campus facilities plan that will create a campus that meets ... the future. These new care spaces will embody Dayton Children’s ...
(Date:8/22/2014)... CO (PRWEB) August 22, 2014 ... provider of in-home care for seniors, is proud to ... Webinar Series. The upcoming webinar will feature Dr. Suzanne ... at Lenox Hill Hospital in New York City, National ... and author. The webinar will cover the issues surrounding ...
(Date:8/22/2014)... FRIDAY, Aug. 22, 2014 (HealthDay News) -- College can be ... number of things they can do to make the most ... "a time to adjust, explore, meet new people and learn ... director of student wellness and assessment at St. John,s University ... "Not all learning takes place in the classroom. College ...
Breaking Medicine News(10 mins):Health News:Restore My Vision Today: Review Exposes Natural Eye Restoration Guide by Dr. Sen and Dr. Samantha Pearson 2Health News:Dr. Reisner Joins CarePoint Health Medical Group 2Health News:Dayton Children's Hospital Breaks Ground on New, Eight-story Patient Care Tower 2Health News:Dayton Children's Hospital Breaks Ground on New, Eight-story Patient Care Tower 3Health News:Dayton Children's Hospital Breaks Ground on New, Eight-story Patient Care Tower 4Health News:Dayton Children's Hospital Breaks Ground on New, Eight-story Patient Care Tower 5Health News:Home Care Assistance of Centennial to Host Webinar on Heart Health, Featuring Dr. Suzanne Steinbaum 2Health News:Home Care Assistance of Centennial to Host Webinar on Heart Health, Featuring Dr. Suzanne Steinbaum 3Health News:College Prep 101 2
... , , PHILADELPHIA, ... announced the completion of an extensive in-building solution that will ... Verizon Wireless, high-speed 3G network for the hospital community, including ... The in-building solution improves wireless voice and high-speed ...
... , NORTHFIELD, Ill., Aug. 11 ... to become the first company to use the Smart Choices ... children ages 6-11 in the United States. , , ... Smart Choices Program is a voluntary nutrition labeling system ...
... aspirin in prevention as well as treatment, , TUESDAY, Aug. ... the risk of getting colorectal cancer, but it also might ... research suggests. , People with colorectal cancer who took aspirin ... the cancer and a 21 percent lower risk for death ...
... , WASHINGTON, Aug. 11 Stephen H. Feinstein, Ph.D., ... on Mental Illness board of directors. , , ... years and previously was president of NAMI Kansas. An experimental psychologist, ... in both the private and the public sectors. He also served ...
... 11 /PRNewswire-FirstCall/ - Hard to Treat Diseases, Inc. (HTDS:PK), ... Co., Ltd. (Mellow Hope) is pleased to announce that ... , NCPC is the biggest modern Pharmaceutical manufacturer in ... agreement, Mellow Hope was appointed as the exclusive agent ...
... WASHINGTON, Aug. 11 Even while Cons u ... operated by physicians among the best in the country, some in Congress are ... , The independent testing and research organization released a new study ... Overwhelmingly, Cons u mer Reports found that ...
Cached Medicine News:Health News:Temple University Health System to Benefit from Verizon Wireless Network Enhancements 2Health News:Temple University Health System to Benefit from Verizon Wireless Network Enhancements 3Health News:Kraft Foods First Company to Adopt Smart Choices Program Nutrition Criteria for Advertising to Children in the U.S. 2Health News:Aspirin May Stem Deaths From Colorectal Cancer 2Health News:Aspirin May Stem Deaths From Colorectal Cancer 3Health News:Hard To Treat Diseases (HTDS) exclusive agent and partner of NCPC 2Health News:Hard To Treat Diseases (HTDS) exclusive agent and partner of NCPC 3Health News:Physician Owned and Operated Hospitals Get Top Rankings From Consumer Reports, but They Remain on the Healthcare Reform Chopping Block 2Health News:Physician Owned and Operated Hospitals Get Top Rankings From Consumer Reports, but They Remain on the Healthcare Reform Chopping Block 3
... Incision System - the first family of ... The System has been methodically designed to ... knives. Beaver safety knives have an ... both protects healthcare workers from sharps injury, ...
The Escape Basket offers a side-by-side approach, unique to the market, for using a nitinol basket and holmium laser fiber together-providing physician control and independent manipulation of both th...
The Surgiflex WAVE XP couples the state-of-the-art Surgiflex WAVE Probe with the convenience of a truly portable battery-powered pump....
The Surgiflex WAVE XP couples the state-of-the-art Surgiflex WAVE Probe with the convenience of a truly portable battery-powered pump....
Medicine Products: