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Pieris Demonstrates Potent Anti-Tumor Activity of a VEGF-Specific,Anticalin in Preclinical Studies

t role in several diseases. Although various pro- and anti-angiogenic factors have been identified, Vascular Endothelial Growth Factor (VEGF) has been implicated as the key angiogenic factor in cancer and neovascular eye disorders.

The PRS-050 program has been designed to develop Anticalins(R) that specifically bind and block the signalling activity of VEGF. PRS-050 exhibits a favourable binding and functional in vitro activity profile in direct comparison to all currently approved

VEGF antagonists. Strong inhibition of VEGF-induced enhanced vascular permeability and strong anti-tumor activity could be demonstrated in vivo.

Pieris will exploit in the PRS-050 program the compact structure, intrinsic stability, broad formulation flexibility and small molecular size of Anticalins(R) to develop products with enhanced penetration into neovascularized tissues for indications such as age-related macular degeneration (AMD) or diabetic retinopathy. Anticalins(R) with extended serum half life will be employed for the treatment of solid tumors.

    Further information is available at http://www.pieris-ag.com

    Anticalin(R), Anticalins(R) are registered trademarks of Pieris AG.


    Contact:

    Pieris AG

    Dr Andreas Hohlbaum,

    Dir. of Science & Preclin. Dev.,

    Phone: +49-(0)-8161-1411-400



CONTACT: Contact: Pieris AG, Dr Andreas Hohlbaum, Dir. of Science &Preclin. Dev., Phone +49-(0)-8161-1411-400

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