Navigation Links
Pieris Demonstrates Potent Anti-Tumor Activity of a VEGF-Specific,Anticalin in Preclinical Studies

t role in several diseases. Although various pro- and anti-angiogenic factors have been identified, Vascular Endothelial Growth Factor (VEGF) has been implicated as the key angiogenic factor in cancer and neovascular eye disorders.

The PRS-050 program has been designed to develop Anticalins(R) that specifically bind and block the signalling activity of VEGF. PRS-050 exhibits a favourable binding and functional in vitro activity profile in direct comparison to all currently approved

VEGF antagonists. Strong inhibition of VEGF-induced enhanced vascular permeability and strong anti-tumor activity could be demonstrated in vivo.

Pieris will exploit in the PRS-050 program the compact structure, intrinsic stability, broad formulation flexibility and small molecular size of Anticalins(R) to develop products with enhanced penetration into neovascularized tissues for indications such as age-related macular degeneration (AMD) or diabetic retinopathy. Anticalins(R) with extended serum half life will be employed for the treatment of solid tumors.

    Further information is available at http://www.pieris-ag.com

    Anticalin(R), Anticalins(R) are registered trademarks of Pieris AG.


    Contact:

    Pieris AG

    Dr Andreas Hohlbaum,

    Dir. of Science & Preclin. Dev.,

    Phone: +49-(0)-8161-1411-400



CONTACT: Contact: Pieris AG, Dr Andreas Hohlbaum, Dir. of Science &Preclin. Dev., Phone +49-(0)-8161-1411-400

Terms and conditions of use apply
Copyright © 2007 PR Newswire Association LLC. All rights reserved.
A United Business Media Company


'"/>




Page: 1 2 3

Related medicine technology :

1. Pieris Progresses Proprietary Asthma Program: Validation of Pulmonary Delivery of Anticalin-Based Protein Product Candidate
2. Pieris Progresses Development of its Proprietary Biotherapeutics Platform: Successful Demonstration of Dual Targeting With Duocalin(R) Technology
3. The International Myeloma Foundation Says Data Reported at a Global Medical Meeting in Greece Demonstrates Improved Survival for a Wide Range of Myeloma Patients
4. Publication on Pixantrone Preclinical Studies Demonstrates Reduced Cardiotoxicity Compared to Equiactive Doses of Doxorubicin and Mitoxantrone
5. New Research Demonstrates Broad Efficacy of Azixa (MPC-6827) Against Multiple Tumor Types and in Drug Resistant Cell Lines
6. Algeta Demonstrates Targeted Cancer-killing Potential of Novel Alpha Particle Linked Antibodies in Leading Medical Journal Blood
7. Gerons Telomerase Inhibitor Cancer Drug Demonstrates Good Pharmacokinetics and Tolerability in Phase I/II Trial
8. Frova Phase III Study Data Demonstrates That Short-Term Prevention Treatment Reduces Frequency and Severity of Menstrual Migraine
9. Mymetics HIV Vaccine Demonstrates First-Ever Production of Neutralizing IgA Antibodies in Non-Human Primate Model
10. Newly Published Data Demonstrates Superiority of Cipralex Over Duloxetine for Acute Treatment of Depression
11. Introgens Advexin Demonstrates Clinical Benefit in Inherited Cancer
Post Your Comments:
(Date:12/24/2014)... N.J. , Dec. 24, 2014 ... a late-stage biopharmaceutical company developing products that address ... oncology and biodefense, announced today that on December ... public offering. The Company raised approximately ... and intends to use the net proceeds from ...
(Date:12/24/2014)... LONDON , December 24, 2014 ... grow at an average rate of 8.1%. The US ... Hip, knee and spine surgeries are the common orthopedic ... they have a lower penetration. Increased number of product ... composites. Non-metallic orthopedic devices have gained popularity in the ...
(Date:12/24/2014)... LifeScienceIndustryResearch.com adds 2014 ... Industry of 178 pages providing 10 company ... The 2014 Market Research Report ... professional and deep research report on Global ... report introduces Disposable Syringe basic information including ...
Breaking Medicine Technology:Soligenix Announces Closing of Public Offering of Units 2Soligenix Announces Closing of Public Offering of Units 3Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 2Use of Composites in Orthopedic Industry to Reach $596 Million by 2020 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 2World Disposable Syringe Market 2014 Report: China and Regional Analysis 3World Disposable Syringe Market 2014 Report: China and Regional Analysis 4World Disposable Syringe Market 2014 Report: China and Regional Analysis 5
... PITTSBURGH, May 25, 2011 Mylan Inc. (Nasdaq: ... has launched Oxycodone Hydrochloride (HCI) Tablets USP, 5 mg, 15 ... agreement with Coastal Pharmaceuticals. This product is the generic version ... Oxycodone HCI Tablets had U.S. sales of ...
... 2011 FUJIFILM Medical Systems U.S.A., Inc. is pleased ... of the FDR D-EVO™ Wireless. This new wireless version ... deliver Fujifilm,s renowned image quality in a lightweight design ... a wider variety of imaging applications. The FDR D-EVO ...
Cached Medicine Technology:FUJIFILM's FDR D-EVO™ Wireless Now Available in the U.S. 2
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... MONDAY, Dec. 19 (HealthDay News) -- Most parents who come ... safety of the toys they buy, asking about toxins like ... Kathie Dockstader, said. "They want to know about the ... toy safety laws in effect now," Dockstader said. "Each and ...
... at the University of Adelaide will focus on treatment ... and genetic variations between people. The Centre for ... researchers with strengths in blood cancers and solid tumours, ... Professor David Callen, the team will use tumour profiling ...
... News) -- Obese Americans have smaller paychecks than those who ... a new study finds. The analysis of data from ... overall average annual incomes were $8,666 less for obese women ... workers. In 2008, obese women made an average of ...
... -- From buying a Christmas tree to stringing up lights and ... parents and guardians should consider during the holidays, according to child ... tips to help keep children and the whole family safe: ... select an artificial tree, that it is flame-resistant. When ...
... breast irradiation using brachytherapy (APBIb) for the treatment ... the last several years in the U.S. as ... to a study published December 16th in the ... . Various types of APBI recurrence (external ...
... way to double the efficacy and reduce the side effects ... a way to reduce lung cancer cells, ability to repair ... is a great therapy the problem is the side ... of Research and Chief, Nanomedicine and Gene Regulation at the ...
Cached Medicine News:Health News:Choosing a Toy? Think 'Kid-Powered' 2Health News:New personalized treatment options for cancer 2Health News:Obesity Linked to Lower Paychecks 2Health News:Pediatricians Offer Tips to Avoid Holiday Hazards 2Health News:Pediatricians Offer Tips to Avoid Holiday Hazards 3Health News:Advantages and motivations uncertain behind use of brachytherapy for breast cancer radiotherapy 2Health News:Advantages and motivations uncertain behind use of brachytherapy for breast cancer radiotherapy 3Health News:Scientists may be able to double efficacy of radiation therapy 2
... This BioSafe room is configured specifically ... and chemical analysis. Panels are precision-joined ... easy to wipe down and disinfect. ... double-wall panel design creates strong, rigid ...
... Features hardwall acrylic panels ... frame to form a free-standing ... to Class 10/ISO 3. Optional ... and ionizers are configured to ...
... curtains or parting strip shields ... frame to form a free-standing, ... cleanliness to Class 10/ISO 3. ... lights, and ionizers are configured ...
... cleanroom for biological safety labs (BSL) ... (to Class 10/ISO 3) and easy ... ultra-smooth surfaces that are easy to ... corners simplify cleaning. Unique double-wall panel ...
Medicine Products: