Navigation Links
Pieris Demonstrates Potent Anti-Tumor Activity of a VEGF-Specific,Anticalin in Preclinical Studies

FREISING-WEIHENSTEPHAN, Germany, March 29, 2007 /PRNewswire/ -- Pieris AG, a bio-pharmaceutical company developing therapeutic products comprising of Anticalins(R), a novel proprietary class of human binding proteins, announced today it has demonstrated potent anti-tumor activity of PRS-050. The positive results with PRS-050, a VEGF-specific Anticalin(R) with extended serum half life, were achieved in a tumor xenograft model, thereby supporting the development of a superior biotherapeutic for a range of cancer indications.

PRS-050 targets VEGF, a key positive regulator of angiogenesis important in several diseases including cancer and neovascular eye disorders. PRS-050 exhibits a favorable binding and functional in vitro activity profile in direct comparison to all currently approved VEGF antagonists. Strong reduction of VEGF-induced enhanced vascular permeability after systemic administration of PRS-050 was also demonstrated in a second preclinical model. In both in vivo models PRS-050 was at least as efficacious as Avastin(R) (bevacizumab; Genentech / Roche). The data will be presented at CHI's forthcoming Protein Engineering Summit in Boston, USA.

"This example highlights perfectly how Pieris is able to adapt pharmacokinetic properties of Anticalins(R) depending on the intended therapeutic use. It took less than three months after identification of an optimized Anticalin(R) to validate the approach in vivo," comments Dr Andreas Hohlbaum, Director of Science and Preclinical Development of Pieris.

"We have unequivocally demonstrated the drug development potential of Anticalins(R) using well-accepted disease relevant preclinical models," says Evert Kuppers, Chief Executive Officer of Pieris. "With our PRS-050 we have now established a solid fundament for developing the next generation of anti-angiogenesis inhibitors with a favorable product profile."

Notes to Editors

About Pie
'"/>




Page: 1 2 3

Related medicine technology :

1. Pieris Progresses Proprietary Asthma Program: Validation of Pulmonary Delivery of Anticalin-Based Protein Product Candidate
2. Pieris Progresses Development of its Proprietary Biotherapeutics Platform: Successful Demonstration of Dual Targeting With Duocalin(R) Technology
3. The International Myeloma Foundation Says Data Reported at a Global Medical Meeting in Greece Demonstrates Improved Survival for a Wide Range of Myeloma Patients
4. Publication on Pixantrone Preclinical Studies Demonstrates Reduced Cardiotoxicity Compared to Equiactive Doses of Doxorubicin and Mitoxantrone
5. New Research Demonstrates Broad Efficacy of Azixa (MPC-6827) Against Multiple Tumor Types and in Drug Resistant Cell Lines
6. Algeta Demonstrates Targeted Cancer-killing Potential of Novel Alpha Particle Linked Antibodies in Leading Medical Journal Blood
7. Gerons Telomerase Inhibitor Cancer Drug Demonstrates Good Pharmacokinetics and Tolerability in Phase I/II Trial
8. Frova Phase III Study Data Demonstrates That Short-Term Prevention Treatment Reduces Frequency and Severity of Menstrual Migraine
9. Mymetics HIV Vaccine Demonstrates First-Ever Production of Neutralizing IgA Antibodies in Non-Human Primate Model
10. Newly Published Data Demonstrates Superiority of Cipralex Over Duloxetine for Acute Treatment of Depression
11. Introgens Advexin Demonstrates Clinical Benefit in Inherited Cancer
Post Your Comments:
(Date:12/17/2014)...  ImmunoCellular Therapeutics, Ltd. ("ImmunoCellular") (NYSE MKT: IMUC) ... (USPTO) has issued a key patent covering ImmunoCellular,s ... targeting six tumor antigens that are commonly expressed ... 8,871,211, which issued October 28, 2014, include methods ... cell composition comprising peptide epitopes of the six ...
(Date:12/17/2014)... RALEIGH, N.C. , Dec. 17, 2014 /PRNewswire/ ... Integrated Clinical Trial Services, LLC (ICTS), two firms ... trials announce that they have formed a joint ... i-CTMS will provide a broad range of patient ... medical device companies. i-CTMS will be ...
(Date:12/15/2014)... Research and Markets ( http://www.researchandmarkets.com/research/vt6973/mems_gyroscopes ... "MEMS Gyroscopes Analog Devices ADIS16136 Precision Angular Rate ... offering. http://photos.prnewswire.com/prnh/20130307/600769 ... made a lot of progress in the past ... now accepted in high-reliability environments, and are even ...
Breaking Medicine Technology:ImmunoCellular Therapeutics Announces Issuance of Key Patent For ICT-107 Cancer Vaccine 2Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 2Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 3MEMS Gyroscopes Analog Devices ADIS16136 Precision Angular Rate Sensor Reverse Costing Analysis 2
... announced today that TRAKnet Practice Management Software 2.0 is ... EHR on October 28th, 2010 by the Certification ... accordance with the applicable Eligible Provider certification criteria adopted ... 2011/2012 criteria support the Stage 1 meaningful use measures ...
... MedSolutions ( www.medsolutions.com ), a leading provider of medical ... Institute and the Office of Continuing Education at Tufts ... webinar designed to assist primary care physicians and pediatricians ... "Doing the Right Thing: Diagnostic Radiology, Radiation Risk, and ...
Cached Medicine Technology:BioMedix's TRAKnet Practice Management Software Receives ONC-ATCB 2011/2012 Certification 2BioMedix's TRAKnet Practice Management Software Receives ONC-ATCB 2011/2012 Certification 3BioMedix's TRAKnet Practice Management Software Receives ONC-ATCB 2011/2012 Certification 4MedSolutions Offers Free CME Credit Imaging Safety Webinar for Physicians 2MedSolutions Offers Free CME Credit Imaging Safety Webinar for Physicians 3
(Date:12/20/2014)... (PRWEB) December 20, 2014 Recently, AngelWeddingDress.com ... Christmas Discount ”) for the coming Christmas. In the ... to 80% off. , “We have something special for ... for the holiday season. Moreover, our new collections of ... models are offered now at greatly discounted prices. Visit ...
(Date:12/20/2014)... Twin Cities DI Day is recognized as the premier ... financial professionals come together each year to hear up ... to protect their clients and to be inspired by ... of disability. , On September 23rd, 2014, financial professionals ... The 13th Annual Twin Cities DI Day where they ...
(Date:12/19/2014)... December 20, 2014 Today, Balfleet.com ... special-occasion outfits, announces its formal dress promotion. All the ... up to 60% off. , Balfleet.com is well-known for ... bridesmaid dresses, prom dresses, cocktail dresses and more. Its ... 30-day money-back guarantee, and they can create an elegant ...
(Date:12/19/2014)... (PRWEB) December 19, 2014 Sub Zero Ice ... sponsor a blood drive Sunday the 28th from 2pm-6pm at ... & Sawyer Road in Sarasota, FL. , Inquiries regarding time ... you for participating in the donating process, Sub Zero Ice ... flash frozen, custom ice cream. , About Sub Zero Ice ...
(Date:12/19/2014)... Silver Dollar City is picking up new ... first time ever, Silver Dollar City has a title in ... listing the park’s wood coaster Outlaw Run as the record ... this week, Silver Dollar City is named in CNN Travel’s ... Today’s 10Best awards for “Best Public Lights Display,” and is ...
Breaking Medicine News(10 mins):Health News:AngelWeddingDress Has Introduced Its Special Offer For The Coming Christmas 2Health News:The 13th Annual Twin Cities DI Day Now On Video 2Health News:The 13th Annual Twin Cities DI Day Now On Video 3Health News:Balfleet.com Announces Its Formal Dress Promotion For 2015 2Health News:Shark Tank’s Sub Zero Ice Cream Sponsors Blood Drive 2Health News:Silver Dollar City Nets New Titles: Guinness Book of World Records, Plus CNN Travel, USA Today & Fodor’s Top Places for Christmas Lights 2
... critical care experts at Johns Hopkins shows that use of ... programs can be introduced to the care of critically ill ... of the drowsiness-inducing medications not only allows patients to exercise, ... periods of bed rest, but also reduces bouts of delirium ...
... ... achieves skin shrinkage of up to 40% one month post-procedure, allowing patients lose up ... ... -- Recent studies conducted by leading plastic surgeon Dr. Mokhtar Asaadi reveal that patients ...
... confusing, incomplete instructions, study finds , THURSDAY, April ... the United States receive prescription instructions from the ... potentially hazardous to their health, a new study ... deficiencies in computer programs that most pharmacies rely ...
... Risk may stem from cumulative effect over many years, study ... breathing disorder known as obstructive sleep apnea more than doubles ... and beyond, new research has found. , U.S. researchers looked ... with no history of stroke, who were participating in the ...
... CITYAfter receiving only the fourth U.S. implant of a new-generation, ... heart failure is looking forward to resuming an active life ... Hospital. Douglas Wiley, Kuna, Idaho, received the Levacor ... the University and is anxious to give his new VAD ...
... lead to treatment for heart failure, aortic aneurysm, researchers ... levels or lack of a certain genetic factor are ... researchers. , This factor -- known as Kruppel-like Factor ... to maintain structural and functional integrity. A team from ...
Cached Medicine News:Health News:More benefits found from mild exercise in critically ill patients 2Health News:More benefits found from mild exercise in critically ill patients 3Health News:More benefits found from mild exercise in critically ill patients 4Health News:Recent Studies Show MAstertuck℠ Technique Removes Large Amounts of Body Fat without Tummy Tuck Surgery 2Health News:Recent Studies Show MAstertuck℠ Technique Removes Large Amounts of Body Fat without Tummy Tuck Surgery 3Health News:Recent Studies Show MAstertuck℠ Technique Removes Large Amounts of Body Fat without Tummy Tuck Surgery 4Health News:Prescriptions Translated to Spanish Could Be Hazardous to Health 2Health News:Prescriptions Translated to Spanish Could Be Hazardous to Health 3Health News:Even Mild Sleep Apnea Raises Stroke Risk in Men 2Health News:Utah-made ventricular assist device gives Idaho man chance to resume an active life 2Health News:Single Genetic Factor Key to Cardiovascular System 2
PremierEdge Stab Knives - 30....
PremierEdge™ Stab Knives - 15°....
Interchangeable design allows you to select a single handpiece and change tips during the procedure. Universal connector. Disassembles for easy cleaning. Tips can rotate 360 degrees to re-orient port...
Interchangeable design allows you to select a single handpiece and change tips during the procedure. Universal connector. Disassembles for easy cleaning. Tips can rotate 360 degrees to re-orient port...
Medicine Products: