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Pharmaxis Reports Phase II Results for Aridol in COPD

epted as an important measure in determining the prognosis of patients with COPD3 and a simple test such as Aridol to identify hyper-responsiveness and monitor the effects of treatment is needed.

"Spirometry is not a good enough indicator of disease progression in COPD patients. Major international studies have also shown that inhaled corticosteroids fail to affect lung function, as measured by spirometry, in patients with mild to moderate COPD2."

To further enhance the role of Aridol in COPD management, Pharmaxis is therefore supporting an additional, and larger, study in subjects with COPD to be run in Switzerland. In the forthcoming trial, subjects with COPD and no previous exposure to inhaled corticosteroids will be treated according to the global prescribing guidelines4 and tested with Aridol before and after three months treatment with an inhaled bronchodilator and an inhaled steroid. The Swiss trial will use Aridol and not spirometry as the principal measure of disease control. The first patient is expected to be enrolled into this study in April 2007 and the study should conclude during the first half of 2008.

There are more than 30 million COPD sufferers in the developed world. Deaths from COPD have risen by 14% in men and 185% in women between 1984 and 2000. COPD is the fourth leading cause of death in the U.S. and the only major cause of death that continues to rise.

For more details about the current trial, refer to the trial's disclosure summary below.

To find out more about Pharmaxis, go to http://www.pharmaxis.com.au

For trial information about recruitment, subjects and end points go to page3, http://www.pharmaxis.com.au/library/2007_03_14_COPD201.pdf

    1: Chest: (2003) 124, 449-458

    2: British Medical Journal (2000) 320, 1297-1303

    3: Respira
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