Navigation Links
Pharmasset Presents Clevudine and Racivir Data at the International,HIV Drug Resistance Workshop

.

Clonal Analysis of Samples from Virologic Responders Receiving Racivir in Study 201

De La Rosa A, Lloyd R, Otto MJ

Study Conclusion: Racivir effectively reduced viral loads by a mean of 0.7 log10 (80% reduction) in responders harboring the M184V mutation and fewer than 3 TAMs at day 28. Clonal genotypic analysis of virus from responders indicated that the M184V mutation was found on all clones in addition to multidrug resistance-associated mutations observed with first line therapy failure.

About Clevudine

Clevudine is an oral, once-daily pyrimidine nucleoside analog that is in development for the treatment of HBV. Clevudine is approved for HBV in Korea, and it is marketed by Bukwang Pharmaceuticals under the brand name Levovir. In addition to its on-treatment efficacy, Clevudine has demonstrated sustained virologic response (SVR) for HBV, or undetectable virus 24 weeks after stopping therapy. We plan to initiate two Phase 3 clinical trials of Clevudine for registration in the United States, Europe and South America in the third calendar quarter of 2007.

About Racivir

Racivir is an oral, once-daily cytidine nucleoside analog that is in development as an HIV therapy for use in combination with other approved HIV drugs. We have completed a Phase 2 clinical trial, Study 201, to assess the safety, tolerability and antiviral effect of a 600 mg dose of Racivir head-to- head against lamivudine in HIV-infected, treatment-experienced patients with the M184V mutation who have been on lamivudine therapy. Racivir demonstrated antiviral activity in patients harboring HIV with the M184V mutation and less than three thymidine analog mutations. These patients have genotypes consistent with first-line HIV therapy failure and may be candidates for second-line treatment regimens that contain Racivir. Future studies will be designed to explore this potential use of Racivir in a combination therapy for second-line therapy for HIV.

<
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Pharmasset Announces Clevudine and Hepatitis C Presentations at EASL
2. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
3. European Society for Medical Oncology (ESMO) Presents Data from the Clinical Trial of MediGenes Cancer-Killing Virus in Press Conference
4. Cytogen Presents Phase 1 Data Showing Promising Antitumor Activity and Safety Profile of Quadramet at International Myeloma Workshop
5. SemBioSys Presents Positive Insulin Data at the American Diabetes Association Conference
6. Tranzyme Pharma Presents Initial Phase IIa Data for its Novel Ghrelin Agonist, TZP-101, in Patients with Diabetic Gastroparesis
7. Novagali Pharma Presents at AACO the Results of its Pivotal Phase III Clinical Trial of Vekacia in Children Suffering From Vernal Keratoconjunctivitis
8. BioLife Solutions Presents Data on CryoStor at International Society for Cellular Therapy Annual Meeting
9. Genaera Presents Preclinical Data on Trodusquemine (MSI-1436) for the Treatment of Obesity at the American Diabetes Association 67th Scientific Session
10. Elixir Pharmaceuticals Presents Preclinical Data Highlighting Its Ghrelin Antagonist Program at the American Diabetes Associations Annual Meeting
11. DiObex Presents Phase 2a Data of DIO-902 Demonstrating Trends of Improved Glycemic Control and Significant Reductions of LDL-Cholesterol and C-Reactive Protein
Post Your Comments:
(Date:8/21/2014)... 21, 2014  Publicis Groupe customer engagement agency ... Partner and Healthcare Industry Group Leader, has been featured ... the most inspiring people in the life-sciences industry. Those ... and development, marketing, technology, creativity, strategy and medicine. ... a partner in its leading Rosetta Consulting practice. In ...
(Date:8/21/2014)... BURLINGTON, Mass. , Aug. 21, 2014 /PRNewswire/ ... of COPD,  physicians in Brazil ... to follow clinical guidelines and commonly prescribe long-acting ... regimens, although they do so within current severe ... combinations (FDCs) that are expected to launch in ...
(Date:8/21/2014)... 2014 /PRNewswire-iReach/ -- ScriptPro has been certified by ... Common Security Framework (CSF). According to Russ ... "We appreciate this rigorous, top-to-bottom audit. Security-minded customers ... certification signifies. Our business partners need to know ... CERTIFICATION PROCESS: ScriptPro,s internal security processes and controls ...
Breaking Medicine Technology:Shannon Hartley Shines in PharmaVOICE 100 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 2Novel Fixed-Dose Combinations for COPD in Brazil and Mexico Will Compete With Well-Established Therapies in an Environment Dominated by Aggressive Cost-Control Mechanisms 3ScriptPro Achieves HITRUST Certification 2
... , , INDIANAPOLIS, Nov. 16 AMD ... laser technology, today announced the addition of Bart Waclawik ... Mr. Waclawik will be responsible for daily global operations, ... the company. Furthermore, he will lead the engineering effort ...
... Nov. 16 Despite the recession, overall growth ... 15 percent in the past two years, according to a ... Solutions. Retail clinic market growth, however, will likely slow to ... 30 percent from 2013-2014, according to the report. , ...
Cached Medicine Technology:AMD LASERS Announces the Addition of Bart Waclawik, New Chief Operating Officer 2Health Care Retail Clinics Continue Gradual Expansion Through 2012: Deloitte Center for Health Solutions Report 2Health Care Retail Clinics Continue Gradual Expansion Through 2012: Deloitte Center for Health Solutions Report 3Health Care Retail Clinics Continue Gradual Expansion Through 2012: Deloitte Center for Health Solutions Report 4
(Date:8/21/2014)... Recently, Top10BestSEOHosting.com has compared many professional SEO ... one of the most reliable suppliers for webmasters who ... been a boom in websites in recent years, and ... the number of web hosting companies that offer a ... HostMonster has been providing hosting solutions to thousands of ...
(Date:8/21/2014)... Recently, Skmen.com, a distinguished garment supplier, has updated ... girls’ casual dresses . From today until August 31, all ... off) when they are shopping at the company’s online store. ... according to the newest quality standards; they are guaranteed to ... dresses, worldwide ladies can also access the other cheap items ...
(Date:8/21/2014)... Lake City, Utah (PRWEB) August 21, 2014 ... ) is pleased to announce the addition of ... over 30 years of healthcare management experience, Gillespie ... His experience includes multiple executive management positions with ... Most recently Kerry served as President of Triad ...
(Date:8/21/2014)... (PRWEB) August 22, 2014 Top10BestSEOHosting.com ... and announces that iPage ( http://www.top10bestseohosting.com/go/iPage/ ) is ... in 2014. , The manager of Top10BestSEOHosting.com ... cheap hosting supplier. Actually, these companies have outperformed ... and customer support. People can get the best ...
(Date:8/21/2014)... Fayetteville, Georgia (PRWEB) August 21, 2014 ... amenities and the atmosphere that comes along with it. ... Fayetteville makes sure that such amenities are available. ... lifestyle community in Fayetteville, Georgia and Community Association Management, ... structure from American Parks Company to provide an additional ...
Breaking Medicine News(10 mins):Health News:Best SEO Hosting Suppliers in the Global Market Recommended by Top10BestSEOHosting.com 2Health News:Charming Girls’ Casual Dresses Now Released by Distinguished Garment Company Skmen.com 2Health News:Kerry Gillespie Appointed as Chief Executive Officer of AVEC Health Solutions 2Health News:iPage Reviews Unveiled Online At Top10BestSEOHosting.com 2Health News:Recreation is the Heart of the Community at Simpson Mill Plantation; Chooses American Parks Company™ for New Playground Equipment 2Health News:Recreation is the Heart of the Community at Simpson Mill Plantation; Chooses American Parks Company™ for New Playground Equipment 3
... , MONDAY, Jan. 3 (HealthDay News) People ... of becoming obese, new study findings show. Researchers at ... from two large U.S. alcoholism surveys conducted in 1991-1992 and ... women with a family history of alcoholism were 49 percent ...
... the U.S has seen a sharp increase in the number ... weeks, gestation. This is approximately 400,000 children each year, comprising ... are treated the same as full-term infants since they are ... that this can be detrimental to a late-preterm infant,s health ...
... Chronic Total Occlusion Summit and Left Main Coronary ... technologies, research findings and new developments in therapeutic ... in chronic total coronary occlusions and left main ... include:, When and why to open a ...
... chemical group to it at a specific site, a protein ... international research team led by scientists at The University of ... of Nature Cell Biology . In addition to ... same deactivation of the enzyme called EZH2 is necessary for ...
... 2011 For the first time, universal standards to ... medication labels to reflect how patients read and understand ... These labels can vary significantly from pharmacy to pharmacy, ... for the safe use of medications. The new standards, ...
... Philadelphia, PA, January 3, 2011 Postoperative adhesions are ... been used in the hopes of preventing these adhesions ... article in the December 2010 issue of the ... American Association of Pediatric Ophthalmology and Strabismus, a team ...
Cached Medicine News:Health News:Family History of Alcoholism May Raise Obesity Risk 2Health News:Care of late-preterm preemies may be insufficient 2Health News:Care of late-preterm preemies may be insufficient 3Health News:Protein wields phosphate group to inhibit cancer metastasis 2Health News:Universal standards proposed for prescription container labels to help reduce medication misuse 2Health News:Universal standards proposed for prescription container labels to help reduce medication misuse 3Health News:Use of amniotic membrane may cause complications in strabismus surgery 2
... disposable pipette tips, TowerPacks are ... Each Sterilized TowerPack is individually ... to help protect tips from ... the red sticker, which indicates ...
... designed to optimize the accuracy and precision ... products is widely recognized by customers throughout ... extended over the years and now covers ... tips including filter tips, certified pure tips, ...
... Finntip Filters are ideal for ... or for any work where ... are designed for pipetting DNA/RNA ... and other. For applications requiring ...
... are ideal for PCR ... or for any work ... occur. They are designed ... infectious materials, labelled samples, ...
Medicine Products: