( tion in tumor size and complete respon...)Peregrine Pharmaceuticals Reports Positive Top-Line Results in,Bavituximab Combination Therapy Trial in Advanced Cancer Patients,Health

tion in tumor size and "complete response" was defined as disappearance of all lesions. Patients were categorized as having "progressive disease" if they had greater than a 20% increase in tumor size or the presence of new lesions. Patients with objective tumor responses (partial and/or complete responses) were eligible to continue with chemotherapy and bavituximab on a compassionate use basis. The trial was conducted according to International Conference on Harmonization (ICH) and Good Clinical Practices (GCP) guidelines.

Bavituximab is a monoclonal antibody that targets and binds to a phospholipid called phosphatidylserine, which is located on the inside of normal cells but which becomes exposed on the outside of the cells that line the blood vessels of tumors, creating a specific target for anti-cancer treatments. Bavituximab is currently in clinical trials in the U.S. for the treatment of solid tumors and as a treatment for chronic hepatitis C infection in patients co-infected with HIV. Clinical data to date has shown that bavituximab is generally safe and well tolerated, and extensive preclinical data demonstrate good anti-tumor activity in a variety of tumor types, especially when bavituximab is administered in combination with chemotherapy or radiation.

Peregrine intends to present more complete data from this trial at an appropriate scientific meeting later this year.

About Peregrine Pharmaceuticals

Peregrine Pharmaceuticals, Inc. is a biopharmaceutical company with a portfolio of innovative product candidates in clinical trials for the treatment of cancer and hepatitis C virus (HCV) infection. The company is pursuing five separate clinical trials in cancer and HCV infection in the U.S. and India with its lead product candidates bavituximab and Cotara(R). Peregrine also has in-house manufacturing capabilities through its wholly owned subsidiary Avid Bioservices, Inc. (http://www.a
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