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Peregrine Pharmaceuticals Highlights Significant Advances in the,Company's Clinical and Preclinical Cancer Programs Presented This,Week at the AACR Annual Meeting

sion proteins. These are combinations of vascular targeting agents such as bavituximab and immune system-stimulating cytokines such as interferon and interleukin-2. Peregrine's immunocytokine fusion proteins showed robust anti-tumor efficacy in animal models of melanoma and B-cell lymphoma, without the signs of toxicity that have limited the wide use of cytokines as anti-cancer agents. In particular, the 85% reduction in tumor growth observed in the B-cell lymphoma model serves as an important validation of Peregrine's VTA immunocytokine approach, and hematological cancers such as lymphoma also represent potential new cancer indications for the company.

Data on Peregrine's VTA coaguligand and VEA anti-cancer development programs.

Researchers working with Peregrine presented data on progress in the company's VTA coaguligand development program, its VEA program and its initiatives to develop second-generation anti-PS monoclonal antibodies.

    *  Peregrine's VTA coaguligands program has developed fusion proteins that

       combine a vascular targeting antibody with modified tissue factor, a

       protein that can induce blocking and destruction of targeted blood

       vessels.  Since Peregrine's VTAs specifically target tumor blood

       vessels, the fusion proteins are intended to affect only the

       established blood vessels that are essential for the survival and

       growth of tumors.  Researchers reported on their progress in

       successfully developing and testing a series of VTA coaguligands that

       currently are in further testing in animal cancer models.


    *  Peregrine researchers gave an oral presentation on novel methods the

       company is employing in its drug discovery efforts for its VEA program.

       VEAs are a new class of therapeutics comprised of tumor-specific

       antibodies fused to vasoactive compound
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