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Peregrine Pharmaceuticals Highlights Significant Advances in the,Company's Clinical and Preclinical Cancer Programs Presented This,Week at the AACR Annual Meeting

tential enhancement to cancer vaccines. In a challenging model of aggressive brain cancer, 57% of animals immunized with a bavituximab equivalent and irradiated, inactivated tumor cells achieved long-term survival compared to 0% in untreated animals and only 16% survival in animals receiving inactive tumor cells with an antibody that does not block PS. To achieve this survival result, the vaccine-like bavituximab regimen is estimated to have enabled these animals to destroy 99.99% or more of the huge tumor cell challenge they were given. These impressive results provide important confirmation of the ability of bavituximab's anti-PS mechanism to reverse the immune system inhibition caused by cancer and offer another potential application for bavituximab and Peregrine's other anti-PS antibodies. * Data demonstrating the potent anti-cancer efficacy of bavituximab in combination with chemotherapy. A bavituximab equivalent in combination with the common cancer chemotherapy docetaxel reduced the growth of both hormone-dependent and hormone-independent prostate cancer by up to 94%. Bavituximab is currently being assessed in a Phase lb cancer clinical trial that includes patients receiving docetaxel. Prostate cancer is one of the most common cancers affecting men and is a leading cause of cancer deaths. * Data supporting use of anti-PS antibodies as the targeting agent for immunocytokine fusion proteins based on Peregrine's VTA platform. Their ability to target phospholipids primarily expressed on the surface of tumor blood vessels enables bavituximab-like antibodies to also serve as targeting agents for Peregrine's Vascular Targeting Agent (VTA) technology platform. Studies presented at AACR assessed the anti-cancer properties of VTA-based immunocytokine fu
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Related medicine technology :

1. Peregrine Pharmaceuticals Reports Positive Top-Line Results in Bavituximab Combination Therapy Trial in Advanced Cancer Patients
2. Positive Results Using Affitech-Identified Human Antibody That Blocks VEGF Binding to VEGF Receptor 2 in Preclinical Cancer Model Reported by Peregrine
3. Data Presented at AACR Meeting Shows Peregrines Immunocytokine Fusion Proteins Reduce Growth of B-Cell Lymphoma Tumors by 85% in Preclinical Studies
4. Data Presented at AACR Meeting Show Peregrines Bavituximab Equivalent Can Generate Curative Immune Responses as Part of a Vaccine-Like Regimen in Preclinical Models of Aggressive Brain Cancer
5. Data Presented at AACR Meeting Shows Peregrines Selective Anti-VEGF Antibodies are as Effective as Avastin(R) in Preclinical Cancer Models
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7. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
8. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
9. Auxilium Pharmaceuticals to Present at the 2007 CEUT Emerging Growth Opportunities Conference
10. Sunesis Pharmaceuticals to Present at the C. E. Unterberg, Towbin Emerging Growth Conference
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