Navigation Links
Peramivir Protects Mice From Lethal H5N1 Infection

St. Jude study shows intramuscular injection of peramivir for eight days protected mice from lethal H5N1 influenza virus infection and inhibited virus replication, supporting the use of this drug to control influenza during a pandemic

MEMPHIS, Tenn., May 01, 2007 /PRNewswire-USNewswire/ -- The antiviral drug peramivir might offer humans significant protection during a pandemic of the avian influenza virus H5N1, according to results of mouse studies conducted by investigators at St. Jude Children's Research Hospital.

Peramivir, an antiviral drug, blocks the ability of influenza viruses to use an enzyme called neuraminidase, thus preventing the release of new virus particles and their spread from one infected cell to another.

The researchers reported 100 percent survival among 10 infected mice given intramuscular injections of peramivir daily for eight days. The drug also inhibited the replication of the deadly strain of H5N1 virus in the lung, brain and spleen. The key to the high survival rate was treating the infected mice within 24 hours after infection with H5N1 and continuing the treatment for eight days.

"Peramivir should be given as soon as H5N1 infection is suspected, since onset of symptoms in infected humans can be delayed," said David A. Boltz, Ph.D., a postdoctoral fellow in the laboratory of Robert G. Webster in the Infectious Diseases department at St. Jude. "The drug could also be given as a preventive measure during an outbreak to decrease the risk of infection." Boltz is first author of a paper that was presented Mon., April 30 at the 20th International Conference on Antiviral Research in Palm Springs, Calif.

"We were surprised that we could also see a 40 percent survival rate among mice after just a single dose of peramivir," said Elena A. Govorkova, Ph.D., a scientific manager in the Infectious Diseases department at St. Jude. Govorkova is the paper's senior author.
'"/>




Page: 1 2 3

Related medicine technology :

1. BioCryst Presents Phase I Peramivir Data at the Options for the Control of Influenza Conference
2. St. Jude Study Shows Effectiveness of Peramivir in Prevention of Mortality in Mouse Model of Avian Influenza H5N1 Virus Infection
3. Ceragenix Compound Shows Promise for Treating Lethal Cystic Fibrosis Infections
4. Novavax Pandemic Flu Vaccine Provided Protection Against a Lethal Challenge of Live Virus, Pre-Clinical Data Show
5. IR BioSciences Announces Data Demonstrating Radilex Stimulation of Stem Cells Results in Hematopoietic Recovery Following Lethal Irradiation
6. New Assays to Detect Disseminated Fungal Infections
7. Antibiotics Dont Prevent Future Urinary Tract Infections, May Cause Resistance in Future Infections
8. Largest National U.S. Healthcare Facility MRSA Study Reveals Infection Rates Eight Times Greater Than Previous Estimates
9. Anadys Pharmaceuticals Nominates ANA598, a Small-Molecule, Non-Nucleoside Inhibitor of The NS5b Polymerase, as a Candidate for Clinical Development in Chronic Hepatitis C Virus Infection
10. Sirion Therapeutics Receives Orphan Drug Designation for Ophthalmic Drug to Treat Viral Eye Infection
11. Five Days of LEVAQUIN(R) as Effective as 10 Days of Ciprofloxacin in Complicated Urinary Tract Infections and Acute Pyelonephritis
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Peramivir Protects Mice From Lethal Infection
(Date:7/29/2015)... According to a new market research report ... Oximeter), Therapeutic [CPAP, APAP, BPAP, Masks (Full Face Mask), ... Settings, Hospitals) - Analysis & Global Forecasts to 2020", ... Apnea Devices Market for the forecast period of 2015 ... Billion by 2020 from $3.7 Billion in 2015 at ...
(Date:7/29/2015)... , July 29, 2015   KaloBios Pharmaceuticals, Inc ... focused on developing innovative therapies to benefit patients with ... oncology, announced today that the U.S. Food and Drug ... (IND) application for KB003, an anti-GM-CSF monoclonal antibody (mAb), ... the IND is now active. The acceptance ...
(Date:7/29/2015)... July 27, 2015 Research and Markets ( ... "3D Metrology Market by Product (CMM, ODS, and VMM), ... & Geography (North America, Europe, APAC, RoW) - Global ... The 3D metrology market was valued ... grow at a rate of 7.11% during the forecast ...
Breaking Medicine Technology:Sleep Apnea Devices Market Worth $5.3 Billion by 2020 2Sleep Apnea Devices Market Worth $5.3 Billion by 2020 3Sleep Apnea Devices Market Worth $5.3 Billion by 2020 4KaloBios Announces FDA Clearance of Investigational New Drug Application for KB003 in Patients with Chronic Myelomonocytic Leukemia 2KaloBios Announces FDA Clearance of Investigational New Drug Application for KB003 in Patients with Chronic Myelomonocytic Leukemia 3KaloBios Announces FDA Clearance of Investigational New Drug Application for KB003 in Patients with Chronic Myelomonocytic Leukemia 4KaloBios Announces FDA Clearance of Investigational New Drug Application for KB003 in Patients with Chronic Myelomonocytic Leukemia 5Global 3D Metrology Market 2015-2020: Products (CMM, ODS, and VMM) & Applications (Automotive, Aerospace, Energy & Power, Medical and Electronics) 2
... Reportlinker.com announces that a new market research report ... The Outlook for Pharmaceuticals to 2012 ... Pharmaceuticals to 2012 is a new collection of management ... individual and highly-detailed analysis of each market, looking at ...
... announces that a new market research report is available ... http://www.reportlinker.com/p098222/Mammography-World-Markets.html The ... phase of growth fueled by the availability of new ... and the higher interest of individual patients and general ...
Cached Medicine Technology:Reportlinker Adds E7: The Outlook for Pharmaceuticals to 2012 2Reportlinker Adds E7: The Outlook for Pharmaceuticals to 2012 3Reportlinker Adds E7: The Outlook for Pharmaceuticals to 2012 4Reportlinker Adds E7: The Outlook for Pharmaceuticals to 2012 5Reportlinker Adds Mammography World Markets 2
(Date:7/29/2015)... ... ... " Core Organizer ” was featured on NewsWatch as part of its monthly AppWatch, ... iOS, Android, and Windows. Joe Toohey, the host of AppWatch and technology expert, conducted ... organized. , Wouldn’t it be great if everyone could be a little more organized? ...
(Date:7/29/2015)... ... July 29, 2015 , ... More ... and service providers of children living with autism will converge upon Penn State ... demographic. , The National Autism Conference will be held Aug. 3-6 at ...
(Date:7/29/2015)... ... July 29, 2015 , ... According to The Spirits Business ... is directly responsible for stimulating and perpetuating alcohol use disorders. Humans have the same ... of the National academy of Sciences, and has given researchers inklings to explore Rsu1 ...
(Date:7/29/2015)... ... July 29, 2015 , ... ... has once again teamed up with Stillwaters Cancer Support Services and announced a ... Stillwaters provides individual and family counseling, support groups, workshops and educational programs at ...
(Date:7/29/2015)... ... July 29, 2015 , ... Wedding season is in full swing, which means bridal ... pressure of looking good on the big day. Every bride wants to look and feel ... level. , According to a recent study by the American Academy ...
Breaking Medicine News(10 mins):Health News:Get More Organized with the Core Organizer App 2Health News:Penn State Conference to Address Instruction, Success for Children with Autism 2Health News:Study Reveals Potential for Gene Manipulation to Stop Alcohol Addiction 2Health News:Study Reveals Potential for Gene Manipulation to Stop Alcohol Addiction 3Health News:Scott Campbell Agency and Nonprofit Stillwaters Cancer Support Services Initiate New Charity Campaign in Waukesha, WI to Provide Help for People Touched by Cancer 2Health News:Scott Campbell Agency and Nonprofit Stillwaters Cancer Support Services Initiate New Charity Campaign in Waukesha, WI to Provide Help for People Touched by Cancer 3Health News:Say I Do To Surgery: Bridal Beauty On The Rise According to New Survey 2Health News:Say I Do To Surgery: Bridal Beauty On The Rise According to New Survey 3
... By Steven Reinberg HealthDay Reporter , FRIDAY, Jan. ... moratorium on controversial research into a modified avian flu virus ... Although the investigators believe their research has a public ... others that the genetically altered virus could escape from labs ...
... , SATURDAY, Jan. 21 (HealthDay News) -- Talking on ... makes it difficult to walk in a straight line, researchers ... in their 20s whose walking abilities were tested when they ... on a cellphone or texting. The participants, walking ...
... -- More than half (51.4 percent) of American adults at ... new study says. People at risk for hepatitis B ... share needles when using injectable drugs and those who engage ... percent of new hepatitis B infections occur among people with ...
... with gynecologic cancer have new hope in a novel ... University Hospitals (UH) Case Medical Center. A team ... among the first in the nation to launch a ... ovarian, endometrial and select other cancers. Performed immediately ...
... , FRIDAY, Jan. 20 (HealthDay News) -- A new ... during pregnancy and common birth defects. However, the ... defects and mothers with asthma, and potentially with their medication ... was a loss of oxygen from less than well-controlled asthma ...
... Jan. 20 (HealthDay News) -- Job-related injuries and illnesses in ... per year, according to a new study. The figure ... more than the direct and indirect costs of all cancers, ... billion more than the costs of stroke, the researchers say. ...
Cached Medicine News:Health News:Scientists Agree to Delay Controversial Bird Flu Research 2Health News:Scientists Agree to Delay Controversial Bird Flu Research 3Health News:Many U.S. Adults Not Vaccinated for Hepatitis B 2Health News:UH Case Medical Center offers new therapy for gynecologic cancer patients 2Health News:UH Case Medical Center offers new therapy for gynecologic cancer patients 3Health News:Asthma Meds Likely Safe During Pregnancy: Study 2Health News:Asthma Meds Likely Safe During Pregnancy: Study 3Health News:U.S. Work-Related Injuries, Illnesses Take Toll on the Till 2
The DePuy ACE Titanium Active Compression Plate offers ingenuity in the art of fracture management....
Coronet Vacuum Trephine - All metal, ergonomic design and ultra sharp blade with cross hairs....
Corneal Trephine Punch - Stainless steel unit with titanium jaws, complete with PTFE cutting block. 1 reusable unit....
Coronet Donor Punch Set - Unique design providing precise control and full visualization throughout the procedure. Corneal marking pen included....
Medicine Products: