Navigation Links
Pacgen Announces Positive Results from Phase I/II Trial of Novel,Antifungal Drug

patients were assessed as clinically cured at day 14 compared to 36% of Nystatin patients. Complete or partial responses at day 14 were observed in 95% of PAC-113 patients and 87% of Nystatin patients in the same population. Results also confirm that PAC-113 was generally safe and well-tolerated.

"We are very encouraged with these clinical results and expect that optimization of PAC-113 dose and formulation, as planned in the next Phase II trial, will further enhance clinical efficacy. We believe that these efforts in conjunction with the product's competitive advantages over existing treatments for oral candidiasis make it an excellent drug candidate to take into late stage studies," said Duffy DuFresne, President & CEO of Pacgen.

About PAC-113

PAC-113 is a 12 amino-acid antimicrobial peptide derived from a naturally occurring histatin protein found in saliva. This peptide alters the permeability of fungal cell membranes causing cell death. In addition, PAC-113 also interacts with fungal mitochondria causing production of reactive oxygen species that lead to fungal cell destruction. This activity is unique to histatin proteins.

Current treatments for Candida infections are not effective in eliminating the infection, can have serious side effects, have significant potential for drug interaction, and/or do not prevent the development of drug-resistant fungal infection. PAC-113 is easily administered and well-tolerated by patients as it is formulated as a sugar-free, pleasant tasting, non-viscous mouthrinse with a neutral pH. It also has a prolonged half-life in the saliva giving it the potential to extend the duration of the therapeutic effect, increasing the cure rate and reducing the time to relapse.

About Candida Infection

Candida albicans is the most common fungal pathogen among immune-compromised, hospitalized patients, accounting for roughly 50-60% of all bloodstream fungal isolates. Opportunistic growth of Candida
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
2. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
3. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
4. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
5. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
6. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
7. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
8. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
9. Protox Announces Positive Clinical Data from Prostate Cancer Study
10. Inspire Announces Webcast of Presentation at C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
11. NexMed Announces Completion of Patient Enrollment in Two Pivotal Phase 3 Studies for Anti-Fungal Product
Post Your Comments:
(Date:10/30/2014)... -- Misonix, Inc. (NASDAQ: MSON ), an international ... innovative therapeutic ultrasonic instruments for spine surgery, neurosurgery and ... financial results for the first quarter fiscal year 2015 ... a conference call that same day, Thursday, November 6, ... Interested parties can access the conference ...
(Date:10/30/2014)... N.J. , Oct. 30, 2014 Stryker ... TOUR and Champions Tour, is rounding out its debut ... Championship in Scottsdale, AZ. This ... TOUR and Champions Tour that the brand has activated ... designed to educate golf fans on the importance of ...
(Date:10/30/2014)... Oct. 30, 2014   NxStage® Kidney Care, Inc ., ... ), is proud to host the grand opening ceremony of ... 1600 W. 16 th Street on November 20, 2014 ... highly trained medical staff who are committed to providing patients ... life benefits made possible through more flexible dialysis treatment options.   ...
Breaking Medicine Technology:Misonix, Inc. To Report First Quarter Fiscal Year 2015 Financial Results On Thursday, November 6, 2014 2Stryker Mobility Zone Makes Final Stop Of 2014 At Charles Schwab Cup Championship 2Stryker Mobility Zone Makes Final Stop Of 2014 At Charles Schwab Cup Championship 3Stryker Mobility Zone Makes Final Stop Of 2014 At Charles Schwab Cup Championship 4Grand Opening of NxStage Kidney Care Oak Brook IL Center 2Grand Opening of NxStage Kidney Care Oak Brook IL Center 3
... 1b study planned for mid 2008 with Phase 2 development ... to begin late in 2008 or in early ... NUVO ) today announced positive results from the Phase 1,proof-of-concept ... offset of anticoagulation after,a single bolus dose with a favorable safety ...
... Erythematosus ... ... (Nasdaq: RIGL ) announced today that its lead product,candidate, R788, ... reported in a recently published,study of the drug candidate. R788 (fostamatinib ...
Cached Medicine Technology:Nuvelo Announces Positive Proof-of-Concept Data With Anticogulant NU172 2Nuvelo Announces Positive Proof-of-Concept Data With Anticogulant NU172 3Nuvelo Announces Positive Proof-of-Concept Data With Anticogulant NU172 4Rigel's R788 Slows Progression of Murine Lupus in Preclinical Studies 2Rigel's R788 Slows Progression of Murine Lupus in Preclinical Studies 3Rigel's R788 Slows Progression of Murine Lupus in Preclinical Studies 4
(Date:10/30/2014)... Indialantic, FL (PRWEB) October 30, 2014 ... products, vitamins, supplements, weight loss aids, and more, is ... The sweepstakes, which is already underway, is open to ... until midnight on December 15, 2014. One lucky winner ... entries to receive a $100 gift card to NutritionLeaders.com. ...
(Date:10/30/2014)... Pompano Beach, Florida (PRWEB) October 30, 2014 ... surprise Halloween visit to Pompano Beach firefighters, showing that ... your community. , Timothy met firefighters Tracey and ... sponsored by Galuppi’s Restaurant and the Pompano Beach Chamber ... and outside the fire truck, letting Timothy wear his ...
(Date:10/30/2014)... October 30, 2014 Graphics, coding, typography ... synonymous with the craft of web design and require ... Yet a simpler solution to create a website can ... videos, contact information, customer reviews and Facebook posts all ... "It is the next evolution of how a business ...
(Date:10/30/2014)... 2014 Don Allred Insurance, a leading ... plans for North Carolina residents, is excited to announce ... Holly Hill Mall. The new branch has been up ... customers through all facets of the insurance selection process ... spokesman Scott Allred couldn’t be happier with the timing ...
(Date:10/30/2014)... Calif. (PRWEB) October 30, 2014 ... mutually exclusive concepts in the medical-grade skin care ... the development of uniquely potent topical dermatological products, ... System ( http://www.RefinitySkinScience.com ) with patented COSMEDERM®-7 anti-irritant ... glycolic acid concentrations (50% and 70%) and a ...
Breaking Medicine News(10 mins):Health News:Nutrition Leaders Announces Gift Card Sweepstakes 2Health News:4-year-old InstaKNOT CEO Honors Local Firefighters with Community Support 2Health News:4-year-old InstaKNOT CEO Honors Local Firefighters with Community Support 3Health News:4-year-old InstaKNOT CEO Honors Local Firefighters with Community Support 4Health News:Facebook Websites In Thirty-Seconds 2Health News:Allred Insurance Satellite Office Grand Opening 2Health News:Cosmederm Redefines Peel Science Standard with Launch of Refinity® Skin Health System 2Health News:Cosmederm Redefines Peel Science Standard with Launch of Refinity® Skin Health System 3Health News:Cosmederm Redefines Peel Science Standard with Launch of Refinity® Skin Health System 4
... of times our cells can divide is dictated by telomeres, ... how telomeres keep our chromosomes and by extension, our ... in the fields of both aging and cancer. Now, scientists ... on the structure and function of a crucial domain in ...
... and the UCLA Henry Samueli School of Engineering and ... of Homeland Security,s Science and Technology Directorate to help ... in the field. The UCLA team will work ... on the agency,s PHASER (Physiological Health Assessment System for ...
... Reporter , WEDNESDAY, Sept. 15 (HealthDay News) -- Fresh on the ... study shows that men who have a low prostate-specific antigen (PSA) ... men with a high PSA reading -- 2 nanograms per milliliter ... risk of developing the disease, the researchers added. "If ...
... risk of cardiovascular disease, stroke, high blood pressure, or ... International Journal of Data Mining, Modelling and Management . ... network computer program to analyze patient data and spot ... for an individual. Khanna Nehemiah of the Anna ...
... HealthDay Reporter , TUESDAY Sept. 14 (HealthDay News) -- A ... has sickened a handful of people in North America, with ... officials said Tuesday. But the bacterium -- designated ... of another bacterium that,s been present in the United States ...
... by Indiana University and Columbia University researchers found no ... mental illness or substance abuse problems despite a greater ... illnesses. The study, published online Sept. 15 ... vexing questions about the effectiveness of campaigns designed to ...
Cached Medicine News:Health News:Protein clamps tight to telomeres to help prevent aging...and support cancer 2Health News:Protein clamps tight to telomeres to help prevent aging...and support cancer 3Health News:UCLA selected by Homeland Security to help establish guidelines for firefighter health and safety 2Health News:Men With Low PSA at 60 Might Not Need Further Screening 2Health News:Men With Low PSA at 60 Might Not Need Further Screening 3Health News:Fuzzy thinking could spot heart disease risk 2Health News:New Drug-Resistant 'Superbug' Reaches U.S. Shores 2Health News:New Drug-Resistant 'Superbug' Reaches U.S. Shores 3Health News:Study: Mental illness stigma entrenched in American culture; new strategies needed 2Health News:Study: Mental illness stigma entrenched in American culture; new strategies needed 3
An enzyme linked immunoassay (ELISA) for the detection and semiquantitation of IgG, IgA or IgM anticardiolipin antibodies, as an aid in assessing the risk of thrombosis in individuals with Systemic L...
... Research Grade Microscope Camera from ImagingPlanet ... imaging technology that delivers increased image ... an affordable price. Document, Archive ... 3.3 mega-pixel digital microscope camera designed ...
The ImagingPlanet 70 mm surgical microscope video adapter: Superior optical quality and precise engineering make this 70 mm focal length adapter an excellent decision for use with your Leica surgica...
The ImagingPlanet 55 mm surgical microscope video adapter: superior optical quality and precise engineering make this 55mm focal length adapter an excellent decision for use with your Zeiss surgical ...
Medicine Products: