Navigation Links
Othera Pharmaceuticals Announces Upcoming Presentation Based Upon,Expanded Understanding of Lead Compound Mechanism of Action

EXTON, Pa.--(BUSINESS WIRE)--Apr 19, 2007 - Othera Pharmaceuticals, Inc. today announced that Dr. Shaker Mousa, Professor of Pharmacology and Executive Vice President and Chairman of the Pharmaceutical Research Institute at Albany College of Pharmacy, will present new preclinical data detailing the observed antithrombotic effect of Othera's lead compound, OT-551, and related Othera compounds. This work stems from previous ocular studies on OT-551 eye drops, as well as studies on novel, orally-available analog compounds under development for non-ophthalmic indications. Dr. Mousa's talk will be presented at the XXI International Society on Thrombosis and Haemostasis (ISTH) Congress in Geneva, Switzerland on July 9, 2007. The ISTH holds its congress every other year and the organization includes 2,800 thrombosis, hemostasis and vascular biology researchers and clinicians from more than 70 countries.

In his abstract, Dr. Mousa describes how OT-551 operates within the cell to downregulate Nuclear Factor kappa B (NF-kB), a transcription factor whose overexpression is associated with a host of inflammation-related ocular and non-ocular diseases. In combination with OT-551's previously known antioxidant and antiangiogenic activities, elucidation of this new mechanism provides strong support for the ophthalmic indications that Othera is currently pursuing with OT-551, as well as new non-ophthalmic indications for analogous oral compounds. Specific diseases of interest to Othera that have been linked to NF-kB overactivity in the scientific literature include age-related macular degeneration (AMD), cataracts, dry eye, resistance to cancer chemotherapy, cancer-related thrombosis and rheumatoid arthritis.

A New Understanding of How OT-551 Works in Ocular Disease

In conjunction with Othera scientists, Dr. Mousa performed large-scale gene expression studies using microchip arrays that provided evidence of OT-551
'"/>




Page: 1 2 3 4

Related medicine technology :

1. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
2. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
3. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
4. Auxilium Pharmaceuticals to Present at the 2007 CEUT Emerging Growth Opportunities Conference
5. Sunesis Pharmaceuticals to Present at the C. E. Unterberg, Towbin Emerging Growth Conference
6. EPIX Pharmaceuticals to Present at the C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
7. Pro-Pharmaceuticals Updates Progress of Clinical Trials & Davanat 505 (b)(2) Filings
8. Cosmo Pharmaceuticals Reports Positive Preliminary Phase II/III Data with Rifamycin MMX in Infectious Diarrhea
9. Portola Pharmaceuticals Announces Positive Phase II EXPERT Results and Additional Oral and Poster Presentations at the XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH)
10. Cyclacel Pharmaceuticals Announces Results of Phase II Seliciclib Combination Studies
11. Arisaph Pharmaceuticals Announces Results of its Potent Smart DPP-4 Inhibitor, ARI-2243, at the ADA
Post Your Comments:
(Date:10/22/2014)... , Oct. 22, 2014  With a ... animal health medications, a Global Pharmaceutical and Biotech ... serialization technology and turnkey solution to protect their ... http://photos.prnewswire.com/prnh/20141021/153438 Photo - ... that was serialized and aggregated by the Xyntek ...
(Date:10/22/2014)... Oct. 21, 2014 Abaxis, Inc. (NasdaqGS: ... blood analysis systems, today reported financial results for the ... Second quarter overview: , Revenues of $53.9 million, ... Diluted EPS of $0.24, up 33% over last year,s ... revenues from Abaxis Veterinary Reference Laboratories (AVRL) of $3.5 ...
(Date:10/22/2014)... Oct. 22, 2014 Sanomedics International Holdings, Inc. ... by Global Research & Data Services, demand for thermometers ... 2014 through 2018, as demand for more accurate digital ... is the world,s largest market for thermometers, and one ... is Sanomedics International Holdings, Inc. Sanomedics International ...
Breaking Medicine Technology:Xyntek and Antares Serialization Solution Protects Pets Too! 2Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 2Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 3Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 4Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 5Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 6Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 7Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 8Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 9Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 10Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 11Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 12Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 13Abaxis Reports Record Revenues for the Second Quarter of Fiscal 2015 14Sanomedics International Holdings Analyst Report: Taking Some Heat by BrokerBank Securities, Inc. 2
... Calif., March 22, 2012  SurgiCount Medical, Inc., the ... (OTCBB:PSTX, OTCQB:PSTX) today announced that it will be ... compliance software tool for use with its market ... Congress in New Orleans, March 24th - 28th.  ...
...  Anaphore Inc. today announced that it has acquired Shanghai-based ... discovery platform focused on the discovery and development of ... was founded by Raymond Stevens, PhD., of The Scripps ... of Shanghai, China. "The acquisition of RuiYi ...
Cached Medicine Technology:SurgiCount Medical Announces Expanded Functionality of the Safety-Sponge® System 2SurgiCount Medical Announces Expanded Functionality of the Safety-Sponge® System 3Anaphore Announces Acquisition of RuiYi in Shanghai China for GPCR Biologics Drug Discovery Platform 2Anaphore Announces Acquisition of RuiYi in Shanghai China for GPCR Biologics Drug Discovery Platform 3
(Date:10/22/2014)... 2014 Shriners Hospitals for Children® and ... the current location of Shriners Hospitals for Children - ... from the University of Kentucky Albert B. Chandler Hospital. ... center, owned and operated by Shriners Hospitals for Children, ... children and their families well into the future. , ...
(Date:10/22/2014)... Best Cheap Hosting USA is among the most ... recently announced that iPower ( http://www.best-cheap-hosting-usa.com/go/iPower/ ) is the ... the world. , “iPower is one of the most ... various kinds of useful products for new and old ... customer service and a number of features which will ...
(Date:10/22/2014)... Richard Carlson, Managing Partner of Blue ... over 25 years experience. Mr. Carlson is a ... related to EDI, B2B Commerce, RFID and Internet/Intranet technology. ... Board member for Pharmaceutical Commerce Magazine and a Gerson ... is a management and technology consulting firm focused solely ...
(Date:10/22/2014)... Tara Haelle HealthDay ... Binge drinking among young adult men may lead to increased ... drinking didn,t cause a similar rise in blood pressure for ... In fact, when young adult women drank lightly or moderately, ... the study found. "This finding parallels studies in older ...
(Date:10/20/2014)... Texas (PRWEB) October 20, 2014 The ... the must-have source of thousands of facts, figures and ... countries and 68 medical sector forecast categories the ... with global, regional and national views on the worldwide ... outlook. , The report gives you data for 2010-2019, ...
Breaking Medicine News(10 mins):Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 2Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 3Health News:Best Cheap Hosting USA Has Recently Announced The Best Cheap Web Hosting Companies In 2014 2Health News:Rich Carlson and Marc Duey to Hold Workshop at CBI’s Specialty Pharmacy and Distribution Networks Conference 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 2Health News:Binge Drinking May Boost Blood Pressure in Young Men 3Health News:Binge Drinking May Boost Blood Pressure in Young Men 4Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 2Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 3Health News:Worldwide Medical Market Forecasts to 2019 a New Research Report Added to ReportsnReports.com 4
... new study of nearly 8,800 women with early-stage breast ... percent completed their full regimen of hormone therapy ... women were particularly likely to discontinue treatment. The findings ... behind such treatment non-compliance and also develop interventions to ...
... ... Vice President to head Client Services, Sandra Fancher , ... (PRWEB) June 28, 2010 -- MedTouch ... Strategy. Fancher will work closely with our award winning healthcare clients developing interactive strategies. ...
... ... a six year success story as a national retailer for traditional German ... more and more requests have been received from nearly all parts ... shipped to the UK, USA and even Australia.,Strandkorb & Meer expects that ...
... universally aware of the oil spill in the Gulf of Mexico, ... of Gulf seafood, according to new data from a continuing survey ... of an ongoing weekly consumer confidence poll conducted by The Food ... survey, 99 percent of respondents said they were aware of the ...
... cancer drugs using gas bubbles and sound waves is to ... enable highly toxic drugs to be delivered in small doses ... to good use. If successful, the technique could easily be ... physicists, chemists and cancer specialists from across the University to ...
... − Scientists at the University of Kentucky,s College of ... individuals at high risk for Alzheimer,s disease that could ... The research, led by Brian Gold, associate professor of ... which forms the majority of deep parts of the ...
Cached Medicine News:Health News:Fewer than half of breast cancer patients adhere to hormonal therapy regimen, study finds 2Health News:Fewer than half of breast cancer patients adhere to hormonal therapy regimen, study finds 3Health News:MedTouch Makes Senior Staff Appointment 2Health News:Strandkorb & Meer Going to Exceed 20% of Total Sales Volume with International Business in 2010 2Health News:Strandkorb & Meer Going to Exceed 20% of Total Sales Volume with International Business in 2010 3Health News:Bursting bubbles with sound offers new treatments for cancer 2Health News:Bursting bubbles with sound offers new treatments for cancer 3Health News:Alzheimer's imaging study identifies changes in brain's white matter 2
... Anesthesia and Respiratory Products, ,Westmed designs, ... for Anesthesia and Respiratory professionals. Our mission ... enhance the clinician's ability to deliver quality ... the bottom line. , ,Our web ...
... Anesthesia and Respiratory Products, ,Westmed designs, ... for Anesthesia and Respiratory professionals. Our mission ... enhance the clinician's ability to deliver quality ... the bottom line. , ,Our web ...
... OMNI~NEB delivers breakthrough continuous low-flow ... and precise nozzle technology allows for ... with or without Heliox). OMNI~NEB takes ... in both routine and critical care ...
... Graham-Field has been developing ... than 58 years. Our medical-surgical ... reputation for innovation, quality and ... brands include the Labtron® line ...
Medicine Products: