Navigation Links
Othera Pharmaceuticals Announces Upcoming Presentation Based Upon,Expanded Understanding of Lead Compound Mechanism of Action

EXTON, Pa.--(BUSINESS WIRE)--Apr 19, 2007 - Othera Pharmaceuticals, Inc. today announced that Dr. Shaker Mousa, Professor of Pharmacology and Executive Vice President and Chairman of the Pharmaceutical Research Institute at Albany College of Pharmacy, will present new preclinical data detailing the observed antithrombotic effect of Othera's lead compound, OT-551, and related Othera compounds. This work stems from previous ocular studies on OT-551 eye drops, as well as studies on novel, orally-available analog compounds under development for non-ophthalmic indications. Dr. Mousa's talk will be presented at the XXI International Society on Thrombosis and Haemostasis (ISTH) Congress in Geneva, Switzerland on July 9, 2007. The ISTH holds its congress every other year and the organization includes 2,800 thrombosis, hemostasis and vascular biology researchers and clinicians from more than 70 countries.

In his abstract, Dr. Mousa describes how OT-551 operates within the cell to downregulate Nuclear Factor kappa B (NF-kB), a transcription factor whose overexpression is associated with a host of inflammation-related ocular and non-ocular diseases. In combination with OT-551's previously known antioxidant and antiangiogenic activities, elucidation of this new mechanism provides strong support for the ophthalmic indications that Othera is currently pursuing with OT-551, as well as new non-ophthalmic indications for analogous oral compounds. Specific diseases of interest to Othera that have been linked to NF-kB overactivity in the scientific literature include age-related macular degeneration (AMD), cataracts, dry eye, resistance to cancer chemotherapy, cancer-related thrombosis and rheumatoid arthritis.

A New Understanding of How OT-551 Works in Ocular Disease

In conjunction with Othera scientists, Dr. Mousa performed large-scale gene expression studies using microchip arrays that provided evidence of OT-551 's effect on several human inflammatory genes regulated by NF-kB. Subsequent animal studies confirmed that OT-551 treatment reduces levels of TNF-(alpha), a key inflammatory cytokine that is regulated in large part by NF-kB. Specific to the area of blood clotting (thrombosis), Dr. Mousa has shown that OT-551 downregulates the expression of tissue factor (TF), an important downstream component of the clotting pathway that is also controlled by NF-kB. Dr. Mousa further demonstrated that OT-551 inhibits thrombosis in whole blood, reversing the clotting that occurs after addition of certain biomolecules, such as anti-VEGF agents for which thrombosis has been identified as a clinical side effect.

"We were impressed by the broad spectrum effect of Othera's compounds in terms of their ability to inhibit not only genes involved in oxidative stress responses, but also inflammatory response genes that control angiogenesis," said Dr. Mousa. "These clues pointed us towards a more complex mechanism of action than the antioxidant activity we had previously observed. We have now proven this hypothesis in multiple animal studies where we induced an inflammatory response and demonstrated an inhibitory effect. This new picture of OT-551's mechanism and its unique ability for topical delivery and high bioavailability supports Othera's choice of ocular clinical targets and strategy."

The OT-300 Program: Building on Lead Compound Mechanism to Identify New Treatments for Oncology and Inflammatory Disease

Based on this new mechanism understanding, Othera has initiated the OT-300 series program, which is aimed at developing orally available analogs of OT-551 for the treatment of non-ophthalmic therapeutic areas. Othera's OT-300 series will target NF-kB mediated diseases including oncology and inflammatory disease. Through a focused drug discovery program that follows the OT-551 mechanism, Othera is identifying and screening novel small molecules for oral delivery to tr eat serious diseases where there is a need for safer and/or more efficacious therapies. Othera has already identified potential lead molecules for its initial disease targets: cancer-associated thrombosis, tumor resistance to chemotherapy (chemoresistance) and rheumatoid arthritis.

Thrombosis associated with cancer remains one of the leading complications leading to death among cancer patients, and select OT-300 compounds could represent a treatment. Dr. Mousa will present data on one or more compounds from the OT-300 Program at the ISTH meeting. Othera intends to complete pre-clinical work in the coming months to support corporate partnering activity for further development of these compounds.

About Othera Pharmaceuticals

Othera Pharmaceuticals, Inc. is a privately-held, specialty pharmaceutical company located in Exton, PA. Othera is designing and developing small molecule products with novel mechanisms of action for ophthalmic and other indications. In ophthalmics, we are developing topical eye drop products for age-related diseases, including some of the leading causes of blindness. Othera is also engaged in the discovery of a novel set of orally-administered compounds to address severe medical conditions including cancer and chronic inflammatory diseases.

Othera's lead compound, OT-551, is an eye drop currently in Phase 2 clinical development. OT-551 has application to several major eye diseases and conditions, including the dry and wet forms of age-related macular degeneration (AMD), cataracts, and dry eye syndrome. Othera's second lead compound, OT-730, is a novel improved beta-blocker in preclinical development for the treatment of glaucoma. More information on Othera Pharmaceuticals is available on the company's website at www.othera.com.

Contact

Othera Pharmaceuticals, Inc., Exton
by
FD Life Sciences
Matt Dallas, 212-850-5627
matt.dallas@f d.com


'"/>




Related medicine technology :

1. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
2. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
3. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
4. Auxilium Pharmaceuticals to Present at the 2007 CEUT Emerging Growth Opportunities Conference
5. Sunesis Pharmaceuticals to Present at the C. E. Unterberg, Towbin Emerging Growth Conference
6. EPIX Pharmaceuticals to Present at the C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
7. Pro-Pharmaceuticals Updates Progress of Clinical Trials & Davanat 505 (b)(2) Filings
8. Cosmo Pharmaceuticals Reports Positive Preliminary Phase II/III Data with Rifamycin MMX in Infectious Diarrhea
9. Portola Pharmaceuticals Announces Positive Phase II EXPERT Results and Additional Oral and Poster Presentations at the XXI Congress of the International Society on Thrombosis and Haemostasis (ISTH)
10. Cyclacel Pharmaceuticals Announces Results of Phase II Seliciclib Combination Studies
11. Arisaph Pharmaceuticals Announces Results of its Potent Smart DPP-4 Inhibitor, ARI-2243, at the ADA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/2/2017)... Aug. 2, 2017 Fenita J. ... as a Pinnacle Lifetime Professional in the Field ... Manager at Turing Pharmaceuticals, AG. Her skills and ... relationship building.                ... 25 years of experience as a highly successful ...
(Date:8/2/2017)... 2017 CaryRx, a next-generation full-service pharmacy, has announced ... patients in the Washington D.C. metropolitan ... providing delivery of medications through the convenience of its patient-friendly ... delivered within one hour to any location in D.C. ... this invaluable service to Washington D.C. ," says ...
(Date:7/31/2017)... MEMPHIS, Tenn. , July 31, 2017 Three Tru-D ... in Yongsan, South Korea . Tru-D, short for "Total ... patient and operating rooms after an environmental services (ES) professional cleans the ... ... "Although ...
Breaking Medicine Technology:
(Date:8/18/2017)... ... August 18, 2017 , ... August 18, 2017 — ... advocating for active, healthy lifestyles and highlighting the importance of proactive eye and ... impairments and shares the latest innovations in hearing aid technology. , According ...
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... ... protection services and financial consultations to communities throughout the greater DC region, is ... with the goal of rescuing local animals and training them to be companions ...
(Date:8/18/2017)... John, IN (PRWEB) , ... August 18, 2017 , ... ... to communities in northwest Indiana, is campaigning in support of Campagna Academy in a ... referred to as the “Hoosier Boys’ Town of Indiana,” Campagna Academy is a nonprofit ...
(Date:8/18/2017)... ... August 18, 2017 , ... With over 16,000 active patients, ... replacement therapy and integrative medicine, has become a frontrunner for people seeking help ... menopause, andropause, thyroid disorder and adrenal insufficiencies. , Founded in 2003 by ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... tracking and monitoring solutions, announced today the launch of a redesigned corporate website, ... navigation and aesthetic, fully responsive design, and an enhanced search directory for businesses ...
Breaking Medicine News(10 mins):