Navigation Links
Organon's Asenapine Effective in a Phase III Study for the,Treatment of Bipolar I Disorder; Results Unveiled at 2007 APA,Meeting

SAN DIEGO, May 21, 2007 /PRNewswire/ -- Asenapine -- an investigational drug being developed by Organon, the human healthcare business unit of Akzo Nobel, for bipolar I disorder and schizophrenia -- was demonstrated to be more effective than placebo in treating acute manic and mixed episodes associated with bipolar I disorder, according to new Phase III results, from a study presented at the American Psychiatric Association's 2007 Annual Meeting.

In the three-week study, patients treated with either asenapine or olanzapine experienced significant improvements in acute mania symptoms, versus patients given placebo. Both asenapine and olanzapine demonstrated superiority versus placebo by the second day of treatment and maintained this benefit throughout the trial.

"The consequences of untreated mania in patients with bipolar disorder can be devastating to patients and their families. We need more effective and more tolerable treatments for these patients," said Robert Hirschfeld, M.D., Professor and Chair of the Department of Psychiatry and Behavioral Sciences at The University of Texas Medical Branch, Galveston. "The results of this trial suggest that asenapine is an attractive option for the acute treatment of mania because of its rapid onset of action and modest side effect profile."

Phase III Study Overview

The Phase III, double-blind, international trial conducted at 55 centers including 29 sites in the United States enrolled 488 patients with a manic (69%) or a mixed episode (31%) of bipolar I disorder and a baseline Young Mania Rating Scale (YMRS) score greater than or equal to 20 at entry. The YMRS is an 11-item scale used to evaluate manic symptoms; a score of at least 20 represents moderate-to-severe mania. Patients were randomly treated with asenapine (5-10 mg twice daily; average daily dose, 18.2 mg), olanzapine (5-20 mg once daily; average daily dose, 15.8 mg), or placebo
'"/>




Page: 1 2 3 4

Related medicine technology :

1. Organons Sugammadex Demonstrated a 9-12 Times Faster Recovery in Phase III Pivotal Trial as Compared to Neostigmine
2. Organons Sugammadex Demonstrated a 9-12 Times Faster Recovery in Phase III Pivotal Trial Compared to Neostigmine
3. New Study Shows That Extending Prophylaxis With Clexane / Lovenox (enoxaparin Sodium Injection) to 5 Weeks is More Effective Than 10 Days for Reducing the Risk of Venous Thromboembolism (VTE) in Acutely ill Medical Patients With Reduced Mobility
4. Eurands Zentase Effective in Treating Exocrine Pancreatic Insufficiency, Studies Show
5. Cimzia Effective in Reducing Signs and Symptoms of Rheumatoid Arthritis
6. Gabapentin Shown Effective for Fibromyalgia Pain
7. ApoCells Cancer Predictive Index Helps Oncologists Select the Most Effective Targeted Drug Therapy
8. Roxro Pharma’s Novel Intranasal Pain Reliever Effective, Well Tolerated in Phase 3 Study
9. XYOTAX More Cost Effective With Fewer Side Effects Than Gemcitabine or Vinorelbine in Treating Non-Small Cell Lung Cancer
10. Soliris Effective in PNH Patients With History of Aplastic Anemia and Myelodysplastic Syndromes
11. Repeated Radioimmunotherapy With 131I-Labetuzumab Appears Safe and Effective in Colorectal Cancer with Liver Metastases
Post Your Comments:
(Date:4/17/2015)... , April 17, 2015  Over the next five years, ... to grow, with ArcView predicting that 14 more states will ... marijuana. The U.S. market for legal cannabis grew 74 percent ... 2013. Analysts project the market could grow more than fourfold ... states soften their stance on marijuana. Cannabiz Mobile ...
(Date:4/17/2015)... 16, 2015 Research and Markets ( ... "Corporate Reputation of Pharma in 2014 - a Perspective ... to their offering. This independent study, funded ... groups with an interest in diabetes on the corporate ... pharma industry as a whole) in 2014. The results ...
(Date:4/17/2015)... Apr. 16, 2015 Research and Markets ... "Corporate Reputation of Pharma in 2014 - a ... report to their offering. For the ... on the corporate reputation of the pharmaceutical industry held ... with the views of patient organisations representing all therapy ...
Breaking Medicine Technology:Cannabiz Mobile Analyst Brief: Next Big Thing by Torus IR Issued by BrokerBank Securities, Inc. 2Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 2Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 3Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 4Perspective of Diabetes Patient Groups on the Corporate Reputation of Pharma in 2014: 130 patient groups with an interest in diabetes from 34 countries 5Corporate Reputation of Pharma in 2014 - The Perspective of Mental Health Patient Groups - 1st Edition 2Corporate Reputation of Pharma in 2014 - The Perspective of Mental Health Patient Groups - 1st Edition 3
... CVS Caremark reiterated the company,s support that the U.S. ... approve biogeneric drugs under the Affordable Care Act. The ... Reid, testified before the FDA today during a public ... for biosimilar and interchangeable biological products held at the ...
... 2010 Spectros Corporation presented new clinical results ... Tissue Oximeter at the San Diego Convention Center ... presented during poster sessions entitled "Experimental Circulation: Ischemia ... the American Society of Anesthesiologists (ASA 2010) on ...
Cached Medicine Technology:CVS Caremark Reiterates Support for FDA Implementation of Approval Pathway for Biogeneric Drugs 2Spectros Presents New Clinical Studies Using T-Stat VLS Tissue Oximeter at Anesthesiology 2010 2
(Date:4/19/2015)... Indiana (PRWEB) April 19, 2015 ... statewide Network Service Provider, announces a major bandwidth ... (AdamsWells) in Bluffton, IN. Craigville Telephone Company, ... has expanded service on IFN’s protected 10 Gigabit ... Zehner, IFN’s Vice President of Sales and Marketing, ...
(Date:4/18/2015)... CA (PRWEB) April 19, 2015 For some ... will proudly display for the rest of their lives, as ... obtaining them and put in a great amount of thought ... a whim, they have outgrown them or simply want them ... of people regret their tattoo, and in 2012-13 there was ...
(Date:4/18/2015)... Carinsurancequotesinfo.com has released a new blog post ... caused by a car accident. , Car ... vehicle. A policy can pay for car repairs and ... always carry appropriate coverage when they are driving. ... with several important riders that offer extra coverage options. ...
(Date:4/18/2015)... 18, 2015 "I recognized the need ... healthcare facilities," said an inventor from Cincinnati, Ohio. "This ... , He developed the Slyde Door to offer an ... healthcare facilities. It provides convenient storage space for an ... stretchers available for patients. , This offers added ...
(Date:4/18/2015)... Insuranceautoquote.info has released a new blog post explaining how ... , Clients can review important auto insurance quotes online, ... important advantages for clients who need affordable financial security ... have coverage for their vehicles can purchase a policy ... Many agencies offer important discounts and drivers can learn ...
Breaking Medicine News(10 mins):Health News:AdamsWells Internet Telecom TV Expands Bandwidth via Indiana Fiber Network, LLC 2Health News:Dennis Dass, M.D. is Shattering the Past While Revealing the Future 2Health News:Auto Insurance Plans Can Cover Physical Injuries Caused By An Accident! 2Health News:Clients Can Review Car Insurance Quotes Online To Find Low Cost Offers! 2
... to reduce transmission from mother to child, experts say ... HIV infection in infants are significantly higher among blacks ... to reduce the disparity, a new government report says. ... overall, among black babies, the rate of perinatal HIV ...
... , SACRAMENTO, Calif. , Feb. 4 ... CEO and Meg Heim, RN , Vice President of Marketing ... Force Committee on behalf of the Governor of California , ... California Department of Chronic Disease and Injury Prevention (CDPH).  The committee ...
... , ATLANTA , Feb. 4 ... Financial Management Association (HFMA) performed a rigorous assessment of ... by Surgical Information Systems, and determined that it meets ... the areas of effectiveness, quality and usability, price, value, ...
... , HAMILTON, Bermuda , ... ("XL" or the "Company") today announced that Chief Executive,Officer Michael S. ... 2010 at the Mandarin Oriental Hotel in Miami, Florida ,on ... A live webcast of Mr. McGavick,s presentation will ...
... , , EDF Testifies 20 Million+ Residents in South ... Calif. , Feb. 4 Environmental Defense Fund ... Standard (NAAQS) for ozone pollution from 75 to 60 parts ... reduce asthma cases 50-fold, according to analyses by the Environmental Protection ...
... (Feb. 4, 2010) Patients with mild gallstone pancreatitis usually ... symptoms to subside, before undergoing surgery to remedy the condition. ... Institute (LA BioMed) indicates patients may no longer have to ... sooner. The study, slated for publication in the ...
Cached Medicine News:Health News:Black and Hispanic Infants Much More Likely to Have HIV 2Health News:BioMedix Vascular Solutions, Inc. Invited to Participate in the California P.A.D. Task Force Committee 2Health News:SIS Rules-Based Charging Solution Successfully Peer Reviewed by HFMA for Third Consecutive Year 2Health News:SIS Rules-Based Charging Solution Successfully Peer Reviewed by HFMA for Third Consecutive Year 3Health News:XL Capital Ltd to Present at Credit Suisse Financial Services Forum on February 11, 2010 2Health News:Stronger Ozone Standard Could Dramatically Reduce Asthma, Premature Deaths 2Health News:Stronger Ozone Standard Could Dramatically Reduce Asthma, Premature Deaths 3Health News:Patients with mild gallstone pancreatitis can undergo surgery sooner, shortening hospital stays 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: