Navigation Links
Orchestra Therapeutics Announces New Phase II Clinical Data on,NeuroVax Demonstrating Marked Expansion of Regulatory T Cell,Populations in Patients With Multiple Sclerosis

- New Data from Open-Label Study Presented at Federation of Clinical Immunology Societies (FOCIS) Annual Meeting -

CARLSBAD, Calif., June 11, 2007 /PRNewswire-FirstCall/ -- Orchestra Therapeutics, Inc. (Bulletin Board: OCHT) announced today positive new data from its completed Phase II open-label study of NeuroVax(TM), an investigational T Cell Receptor (TCR) peptide vaccine for the treatment of relapsing-remitting multiple sclerosis (MS). The new data, presented last week at the Federation of Clinical Immunology Societies (FOCIS) annual meeting, showed that monthly vaccinations over one year with NeuroVax(TM) markedly expanded the capacity of regulatory T cells (Tregs) to recognize TCRs expressed by potentially pathogenic T cells. New data were also presented that showed NeuroVax(TM) produced a significant increase in TCR-specific T cells in patients with MS, including increases in interleukin-10-secreting T cells (IL-10) and Foxp3+ Tregs.

"These new findings provide evidence to support the network hypothesis, in which internal cell-cell recognition of antigen receptors can be greatly expanded in regulatory T cells by activating the system with NeuroVax(TM). These vaccine induced responses may help control the autoimmune processes that are thought to be the main cause of the inflammatory phase of MS" said Arthur A. Vandenbark, M.D., Ph.D., Senior Research Career Scientist at the VA Medical Center, and Professor of Neurology and Molecular Microbiology and Immunology at Oregon Health & Science University in Portland, OR., and lead author on the study. "Increases in both IL-10-secreting T cells and the Foxp3+ Tregs suggest that NeuroVax(TM) can stimulate native thymus-derived Foxp3+ Tregs as well as induce peripheral Foxp3+ Tregs from CD4+CD25- T cells through an IL-10 controlled mechanism."

"These new data suggest that induction of an expanding population of TCR-reactive, Foxp3+ Tregs by NeuroV
'"/>




Page: 1 2 3 4 5

Related medicine technology :

1. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
2. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
3. CV Therapeutics Identifies Potential Anti-Diabetic Mechanism of Action for Ranexa
4. Fat Kills Cancer: Turning Stem Cells from Fat Tissue into Personalized, Cancer-Targeted Therapeutics
5. A 4-Week Therapy with Transition Therapeutics E1-I.N.T. Leads to Sustained Reductions in Blood Glucose Levels for 6 Months Post-treatment in Type 2 Diabetes Patients
6. Clinical Trial Suggests Bone Marrow Stem Cells Are Useful for Spinal Cord Injury; PrimeCell Therapeutics Provided Pre-Clinical Study
7. Opexa Therapeutics Reports Positive Top-line Data in Phase I/II Extension Trial with Tovaxin for Multiple Sclerosis
8. Orexigen Therapeutics to Present Data on Contrave Impact on Visceral Fat and Insulin Resistance at American Diabetes Association 67th Scientific Sessions in Chicago June 23
9. Allos Therapeutics Reports Results for Phase 3 Enrich Study of Efaproxyn in Women With Brain Metastases Originating From Breast Cancer
10. Trophos Publishes ALS Article in Journal of Pharmacology and Experimental Therapeutics
11. Novelos Therapeutics Announces Encouraging Results in Ongoing Phase 2 Ovarian Cancer Trial at Dana-Farber/Partners Cancer Care
Post Your Comments:
(Date:12/19/2014)... -- Monarch America Inc. (OTCQB: CANK) ("Monarch America" or the ... this review of the Company,s recent achievements and strategic ... this past year, we achieved many of our early ... say that Monarch America is in a stronger and ... stated Eric Hagen , CEO of Monarch America ...
(Date:12/19/2014)... 2014  Sage Analytics ( www.sageanalytics.com ), the ... the testing of marijuana potency and moisture content, ... Profiler, the industry,s first product suite capable of ... portable unit. Designed from the ground ... cannabis industry, the Luminary™ Profiler utilizes specially purposed ...
(Date:12/19/2014)... , Dec. 18, 2014 Since last month,s ... site now known as the leading online black market ... explosive growth in its offering of drugs and other ... show the takedowns did succeed in lowering the numbers ... review of the markets in August. But some new ...
Breaking Medicine Technology:Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 3Sage Analytics Develops Breakthrough System for Potency Testing of Cannabis Products 2Post Silk Road - Another Online Drug Den Now Dominates the DarkNet 2Post Silk Road - Another Online Drug Den Now Dominates the DarkNet 3
(Date:12/21/2014)... Columbus, OH (PRWEB) December 21, 2014 ... of men alleging heart attacks, stroke and blood clots ... continue to increase, a new study shows that the ... developing colon cancer. In a study published in the ... lead researcher, James Amos-Landgraf examined a group of male ...
(Date:12/21/2014)... 2014 The Oncology Institute of Hope and ... Ana and Whittier offices. The Hope for the Holidays Toy ... patients and their families during the holiday season. This year, ... 70 children between both offices. This event continues to be ... community service team, store managers and assistant managers came out ...
(Date:12/20/2014)... 21, 2014 BambooIndustry.com is a professional ... . The business has recently shown its new engineered ... all its bamboo flooring models. , BambooIndustry.com’s customers come ... Asia and more. According to the CEO of the ... very fast in the past few years, and the ...
(Date:12/20/2014)... MissyDress, a distinguished special dress supplier, ... The business has drastically cut prices to all its ... until Jan. 30, 2015. Many of the hottest styles ... dresses, lace dresses, and more. , A spokesman for ... day. Whether A-line princess prom dresses or sweetheart chiffon ...
(Date:12/20/2014)... 20, 2014 An improving macroeconomic landscape ... benefited the Massage Services industry over the ... industry products, the anticipated 1.0% annualized increase in per ... consumers with the means to afford additional massages. “While ... massage in a given year has declined from 2009 ...
Breaking Medicine News(10 mins):Health News:New Low Testosterone Therapy Study Shows Male Hormone Testosterone May Contribute To Colon Cancer Reports Wright & Schulte LLC 2Health News:New Low Testosterone Therapy Study Shows Male Hormone Testosterone May Contribute To Colon Cancer Reports Wright & Schulte LLC 3Health News:New Low Testosterone Therapy Study Shows Male Hormone Testosterone May Contribute To Colon Cancer Reports Wright & Schulte LLC 4Health News:BammbooIndustry.com: Big Discounts On All Kinds Of Bamboo Flooring Collections 2Health News:MissyDress: The Prices of Prom Dresses Just Reduced 2Health News:Massage Services in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Massage Services in the US Industry Market Research Report from IBISWorld Has Been Updated 3
... diet high in soy could be good for the hearts ... two separate studies suggest the natural plant estrogens in soy ... estrogen, therefore making soy especially beneficial for women who haven't ... that monkeys that fed on a soy-based diet had better ...
... Smoking is a well known risk factor for bladder ... more factors // that could lead to the disease. ... bladder cancer and 308 people who served as controls. ... their exposure to other environmental factors believed to be ...
... a connection between the use of two of the ... reduced risk for // bone fractures. Beta-blockers are commonly ... chest pain, and abnormal heart rhythms. Some heart attack ... attack. Diuretics are used to remove excess water from ...
... on the rise, taking a heavy toll of lives when compared ... //Research shows about one in every three men can expect to ... exercise lead to a build up of high cholesterol is a ... be. ,Fortunately a lot of research is going ...
... are at a higher risk of developing restless legs ... urge to move the legs and is generally accompanied ... report an increase in symptoms during rest, a partial, ... of symptoms at night. Symptoms tend to progress with ...
... shows women who consume more fruits, vegetables and proteins ... child who develops leukemia. Researchers believe that glutathione // ... risk. ,Researchers studied more than 130 women who ... compared the women’s diets to those of more than ...
Cached Medicine News:Health News:Fixing the way to a Man’s Heart 2
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: