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Opexa Advances Monocyte Derived Islet Technology to Proof of,Principle in stz-induced NOD/SCID Mice

THE WOODLANDS, Texas--(BUSINESS WIRE)--Jun 27, 2007 - Opexa Therapeutics, Inc. (NASDAQ:OPXA), a company involved in the development and commercialization of cell therapies, presented poster presentations at the 5th International Society for Stem Cell Research Annual Meeting (ISSCR) in Cairns, Queensland, Australia from June 17-20 and at the 13th Annual Meeting of the International Society for Cellular Therapy (ISCT) in Sydney, Australia from June 24-27. The two presentations covered recent research from Opexa's innovative adult stem cell program regarding the development of adult monocyte-derived islets, as beta-cell replacement therapy for diabetes mellitus.

The first presentation was made by Opexa's director of stem cell research, Glenn Winnier, Ph.D. at the ISSCR Annual Meeting and described the differentiation of adult monocyte-derived stem cells (MDSCs) to generate pancreatic endocrine cell clusters known as monocyte-derived islets (MDIs). MDIs express pancreatic specific factors as well as hormones insulin, glucagons and somatostatin in physiological proportions. These studies also demonstrated that MDIs function in a glucose responsive manner when transplanted into diabetic animals. Study animals demonstrate a prolonged reduction (greater than 60 days) in blood glucose levels when MDIs were transplanted under the kidney capsule of stz-induced NOD/SCID mice.

The second presentation, also made by Dr. Winnier, was presented at the ISCT Annual Meeting in Sydney, Australia. The Company's recent adult stem cell research has demonstrated the successful generation of MDIs from insulin-dependent type 1 and type 2 diabetics. These insulin producing islet-like clusters express insulin, glucagon and somatostatin characteristic hormones found in pancreatic islets and function in a glucose responsive manner.

Dr. Winnier commented, "The development of adult MDIs from healthy subjects and the demonstration
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