( D chairman and CEOof Antigenics. Alt...)Oncophage Cancer Vaccine Significantly Prolongs Recurrence-Free,Survival by 45 Percent in Patients With Intermediate-Risk Kidney,Cancer,Health

D, chairman and CEO of Antigenics. "Although there are challenges associated with interpretation of subset analyses, the improvement demonstrated in this group of patients supports the opinion of key experts that patients with better prognostic factors are the most appropriate population to benefit from therapeutic cancer vaccines. Combined with decades of preclinical and clinical cancer vaccine data, we believe our results provide a higher level of reliability than that generally associated with outcomes from typical subset analyses."

Study Findings

Results from the investigator-reported data, which represented all data collected through the end of study (March 31, 2007), showed that:

-- Patients receiving Oncophage in the intermediate-risk population (stages I/II high-grade, III T1/2/3a low-grade) who were without disease at baseline (n = 362) demonstrated a clinically significant improvement in recurrence-free survival of approximately 45 percent (P less than 0.01; HR = 0.55). This patient population is defined by the Eastern Cooperative Oncology Group (ECOG) as at intermediate risk for disease recurrence*. Although the median survival has not yet been reached, results from the 25th percentile indicate that recurrence-free survival was extended by approximately 1.8 years in the Oncophage arm.

-- Analysis of overall survival showed improvement associated with Oncophage in the intermediate-risk population. As of data cut-off on January 2, 2006, one additional patient had died in the Oncophage arm versus 13 patients in the observation arm. This now brings the total reported deaths to 15 patients (8.2 percent) in the Oncophage arm compared with 25 deaths (14.0 percent) in the observation arm. The overall survival data are still immature due to the small number of deaths that have occurred to date; patients will continue to be monitored for survival through a global patient registry.

-- Among all eligible patients (intermediate- and
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