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Onconova Therapeutics Announces Presentation of Clinical and,Non-Clinical Results for Its Lead Compound ON 01910.Na at American,Association of Cancer Research Conference in Los Angeles

s, and the combination therapy was as well tolerated as Oxaliplatin treatment alone. This study supports further evaluation of ON 01910.Na and the combination with Oxaliplatin in additional clinical trials in patients with liver, hormone refractory prostate and melanoma tumors (abstract 2271).

An oral presentation, "Phase I study of ON 01910.Na, A Novel Cell Cycle Inhibitor in Adult Patients with Solid Tumors by A. Jimeno, J. Li, M.V.R Reddy, E.P Reddy, A. Chan, X. Zhang, P. Kulesza, J. Wheelhouse, G. Cusatis, A. Howard, M. Maniar, W.A Messersmith, D. Laheru, M. Rudek, S. D. Baker, M. Hidalgo, and R. C. Donehower, summarizes the Phase I study conducted at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Medical Center, Baltimore, MD, in which ON 01910.Na has shown preliminary signs of clinical activity early in development. ON 01910.Na has also evidenced significant preclinical activity against a novel direct pancreatic cancer xenograft model. A gene expression-based assay identifies tumors likely to respond to ON 01910.Na, and will be tested in a Phase II clinical study in pancreatic cancer patients. Integrating early clinical and preclinical development programs is an efficient way to generate rationale for disease-directed studies and biomarkers (oral presentation in a "Breakthroughs in Clinical Research" session on Monday).

Additional scientific studies employing Onconova Therapeutics, Inc., anticancer compounds being presented at this meeting include: "Mass Spectrometric Study of Antibody Drug conjugates" by J. Roboz, S.Y. Cho, S. C. Bell, Glenn J. Fegley, J. L. Duke, S. C. Cosenza and J. F. Holland (abstract 920); "Mass Spectrometric Study of Drug Bound to Protein" by S.Y. Cho, J. Roboz, T. Ohnuma and J. F. Holland (abstract 3182); and "Evaluation of ON 01910.Na, a novel modulator of PLK-1 pathway and development of a cyclin B1 based predictive assay in pancreatic cancer" by A. Jimeno, A. Chan, G. Cusatis, X. Zhang, J. Wheelhouse, A
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