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Onconova Therapeutics Announces Presentation of Clinical and,Non-Clinical Results for Its Lead Compound ON 01910.Na at American,Association of Cancer Research Conference in Los Angeles

LAWRENCEVILLE, N.J.--(BUSINESS WIRE)--Apr 16, 2007 - Onconova Therapeutics, Inc. today announced the presentation of several scientific studies relating to its lead anticancer drug ON 01910.Na at the Annual Meeting of the American Association for Cancer Research (AACR) being held April 14-18, 2007 in Los Angeles, California. During this meeting, on Sunday, April 15th, Dr. E. Premkumar Reddy, the scientific founder of Onconova was honored as the recipient of the 2006-2007 Society of Asian American Scientists in Cancer Research Award for his fundamental contributions to cancer research.

Data presented in oral and poster sessions will focus on pre-clinical and clinical studies with ON 01910.Na, a novel, targeted, small-molecule anti-cancer compound undergoing multiple clinical trials at several major clinical centers in the USA and abroad. ON 01910.Na has shown broad-spectrum anti-tumor activity against both solid tumors and hematological malignancy in pre-clinical studies, and has demonstrated synergistic activity when combined with several classes of conventional chemotherapeutic agents. The Company is planning multiple Phase 2 and combination Phase I clinical trials with leading investigators at major oncology clinical centers in the USA.

The antitumor activity of ON 01910.Na in combination with Eloxatin(R) (Sanofi-Aventis) is demonstrated in a poster presentation entitled, "ON 01910.Na enhances the in vivo cancercidal effects of Oxaliplatin" by J. Jiang, Y. Li, L. Wang, J. Qu, P. Mannam, E. P. Reddy and James F. Holland (Mount Sinai School of Medicine, New York). Employing a nude mouse model system and human liver, hormone refractory prostate, melanoma, pancreatic and colon tumors, single agent activity of ON 01910.Na was shown for all tumor types tested and this effect was enhanced by combining with Oxaliplatin in the liver, prostate and melanoma tumor models. ON 01910.Na was well tolerated in all case
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