( and Medical Oncologist at the BC Cancer...)OncoGenex Technologies Announces Phase II Data of OGX-011 in,Metastatic Breast Cancer at American Association for Cancer,Research 2007 Annual Meeting,Health

"We are encouraged by the conclusion made by the investigators that the combination of OGX-011 and docetaxel has activity in this patient population and by the very low incidence of progressive disease," said Scott Cormack, president and CEO of OncoGenex. "As provided in our previous guidance, these data together with the data from our other Phase II programs in prostate cancer and non-small cell lung cancer, scheduled to be released later this year, will be considered in our planning for subsequent studies, including pivotal trials."

The primary objective of this study was to assess the objective response rates (reduction in tumor size) when OGX-011 is combined with docetaxel in patients with metastatic or locally recurrent breast cancer. Secondary endpoints included estimation of time to disease progression, overall survival and the effect of OGX-011 on serum clusterin.

Fifteen patients were enrolled and all were evaluable for toxicity and response. A median of six treatment cycles were delivered. Grade 3 adverse events commonly associated with chemotherapy alone included: fatigue (33 percent), vomiting (13 percent), edema (13 percent), arthralgias (13 percent) and dyspnea (13 percent). Five patients experienced febrile neutropenia. Investigators concluded that OGX-011 is well tolerated in combination with docetaxel.

Women with measurable metastatic breast cancer and no more than one previous chemotherapy regimen for MBC were eligible for this study. OGX-011 was delivered three times at 640 mg intravenously as a loading phase prior to initiating chemotherapy. The loading phase was followed by a weekly dose of 640 mg of OGX-011 in combination with 75 mg/m2 of docetaxel. Response was evaluated following every s
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