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OREXIGEN Therapeutics Announces Sustained-Release Formulation of,Zonisamide Shows Improved Tolerability When Compared to Immediate,Release Formulation

Stephen Gendel Jason Spark (858) 436-8600 (212) 918-4650 (619) 849-6005

CONTACT: Graham Cooper, Orexigen CFO, +1-858-436-8600; or Media, StephenGendel, +1-212-918-4650, or Investors, Jason Spark, +1-619-849-6005, bothfor Orexigen Therapeutics, Inc.

Web site: http://www.orexigen.com/

Ticker Symbol: (NASDAQ-NMS:OREX)

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