Navigation Links
OREXIGEN Therapeutics Announces Sustained-Release Formulation of,Zonisamide Shows Improved Tolerability When Compared to Immediate,Release Formulation

6. Empatic was associated with significant weight reduction through 48 weeks of treatment but also early discontinuations due to adverse events in approximately 37% of study participants. Zonisamide appeared to be the principal contributing factor, as a similar rate of discontinuations was evident among subjects receiving zonisamide IR therapy alone. Orexigen, in partnership with PharmaDirections, Inc. developed the proprietary SR formulation of zonisamide with the objective of improving its overall tolerability.

"We are excited that our novel, sustained release formulation of zonisamide was significantly better tolerated than the existing generic IR formulation. This is an important consideration in conditions such as obesity that often require longer-term maintenance therapy. Based on these results, we are eagerly awaiting the outcome of our ongoing 24 week Phase IIb multi-center study of Empatic, which incorporates our proprietary formulation of zonisamide SR," said Gary Tollefson, M.D., Ph.D., Orexigen's President and CEO.

About Orexigen(TM) Therapeutics

Orexigen Therapeutics, Inc. is a biopharmaceutical company focused on the development of pharmaceutical product candidates for the treatment of central nervous system disorders, with an initial focus on obesity. Orexigen's lead combination product candidates targeted for obesity are Contrave(TM), which is in Phase III clinical trials, and Empatic(TM) (formerly Excalia(TM)), which is in a Phase IIb clinical trial. Both product candidates take advantage of the Company's understanding of how the brain appears to regulate appetite and energy expenditure, as well as the mechanisms that come into play to limit weight loss over time. Each product candidate is designed to act on a specific group of neurons in the central nervous system with the goal of achieving appetite suppression and sustained weight loss. Further information about the Company can be found at




Page: 1 2 3 4

Related medicine technology :

1. Cell Therapeutics, Inc. Management to Discuss Todays Announcement of Interim Pixantrone Study Results
2. Halozyme Therapeutics Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society
3. CV Therapeutics Identifies Potential Anti-Diabetic Mechanism of Action for Ranexa
4. Fat Kills Cancer: Turning Stem Cells from Fat Tissue into Personalized, Cancer-Targeted Therapeutics
5. A 4-Week Therapy with Transition Therapeutics E1-I.N.T. Leads to Sustained Reductions in Blood Glucose Levels for 6 Months Post-treatment in Type 2 Diabetes Patients
6. Clinical Trial Suggests Bone Marrow Stem Cells Are Useful for Spinal Cord Injury; PrimeCell Therapeutics Provided Pre-Clinical Study
7. Opexa Therapeutics Reports Positive Top-line Data in Phase I/II Extension Trial with Tovaxin for Multiple Sclerosis
8. Orexigen Therapeutics to Present Data on Contrave Impact on Visceral Fat and Insulin Resistance at American Diabetes Association 67th Scientific Sessions in Chicago June 23
9. Allos Therapeutics Reports Results for Phase 3 Enrich Study of Efaproxyn in Women With Brain Metastases Originating From Breast Cancer
10. Trophos Publishes ALS Article in Journal of Pharmacology and Experimental Therapeutics
11. Novelos Therapeutics Announces Encouraging Results in Ongoing Phase 2 Ovarian Cancer Trial at Dana-Farber/Partners Cancer Care
Post Your Comments:
(Date:8/28/2014)... , Aug. 28, 2014  In recognition of ... health complications from the flu, pneumonia, shingles and ... have declared September to be Senior Vaccination ... age, it is important that adults ages 65 ... their vaccinations. CVS pharmacists and MinuteClinic nurse practitioners ...
(Date:8/28/2014)... , Aug. 28, 2014  Stryker Orthopaedics, the Official Joint ... bringing its message of joint health to golf fans at ... at the Deutsche Bank Championship. The company,s fan destination – ... Fan Zone on 9" at the TPC Boston in ... th .    At the Deutsche Bank Championship, ...
(Date:8/28/2014)... , Aug. 28, 2014  Critical Process ... , today announces the expansion of their ... Critical Process Filtration now offers customers and potential ... fluids to filter failure analyses (even for competitor ... to their hallmark services of system benchmarking and ...
Breaking Medicine Technology:September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 2September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 3September is Senior Vaccination Month at CVS/pharmacy and MinuteClinic 4Stryker, Official Joint Replacement Products Of The PGA TOUR, Heads To Boston For The Deutsche Bank Championship 2Stryker, Official Joint Replacement Products Of The PGA TOUR, Heads To Boston For The Deutsche Bank Championship 3Stryker, Official Joint Replacement Products Of The PGA TOUR, Heads To Boston For The Deutsche Bank Championship 4Stryker, Official Joint Replacement Products Of The PGA TOUR, Heads To Boston For The Deutsche Bank Championship 5Critical Process Filtration, Inc. Announces Expanded Technical Services and Validation Support 2
(Date:8/28/2014)... VPS (Virtual Private Server) is the method of ... each of which has the appearance and capabilities ... has recently compared many professional web hosting suppliers ... and IX Web Hosting are the best VPS ... of Top10BestSEOHosting.com says, “These companies have outperformed other ...
(Date:8/28/2014)... Fifty percent of adults who seek ... twenty percent of Americans claim to have fatigue that ... Adrenal Fatigue is the most common yet overlooked cause ... classic symptoms. Tasks that were once a breeze are ... didn’t cause irritation, experiencing weight gain around the middle ...
(Date:8/28/2014)... 2014 Doctors Frank DellaCroce and Scott ... Surgery (CRBS) and the St. Charles Surgical ... announce that board certified surgeon Dr. Craig Ashley Blum ... devoted to reconstructive breast surgery. Blum will work with ... Christopher Trahan, and M. Whitten Wise. , “We are ...
(Date:8/28/2014)... 2014 Involution Studios , ... the healthcare industry's most pressing problems, has launched ... health. Involution Studios' creative team has been ... solutions for clients including AstraZeneca, 3M Health Information ... of the studio's philosophy to change healthcare in ...
(Date:8/28/2014)... August 28, 2014 Starting on Monday, ... is able to accept donations in Bitcoin, in addition ... donation page can be found at http://www.curemeso.org/bitcoin . ... Bitcoin as a form of payment, we decided it ... Meso Foundation’s chief executive officer, Melinda Kotzian. , ...
Breaking Medicine News(10 mins):Health News:Top10BestSEOHosting.com Announces The Best Three VPS Hosting Suppliers 2Health News:Peoria AlignLife Clinics Focus on Community Education 2Health News:New Plastic Surgeon Joins Center For Restorative Breast Surgery 2Health News:Top Three Open Source Design Concepts that Rethink Health from Involution Studios 2Health News:Top Three Open Source Design Concepts that Rethink Health from Involution Studios 3Health News:Cancer Research Funding Organization Now Accepts Bitcoin Donations 2
... think about manipulating tools in the same regions of the brain ... The researchers say this adds to evidence that the brain has ... unusual conditions, such as not having any vision. When ... desk, it sets off a lot of reactions in your brain. ...
... CANADA The rapidly growing polio outbreak in Tajikistan ... other regions in the world, states an editorial ... Association Journal ) www.cmaj.ca . It is imperative ... ensuring high vaccination rates. Polio is a serious ...
... 23, 2010 Patients seeking to conserve privacy and ... to wear a traditional hospital gown that often reveal ... garb. Indeed, researchers from the University of Montreal have ... Alumna Nomie Marquis and Denyse Roy, a professor at ...
... "The objective was to evaluate the utility of cryo-preserved human ... cartilage injuries, which have a very limited capacity for self-healing", ... researcher at the Institute of Biomedical Research of La Corua ... in the journal Cell and Tissue Banking , show ...
... people may want to think twice about taking their shoes ... or wearing slippers or socks with no shoes, may contribute ... from the Institute for Aging Research of Hebrew SeniorLife. ... who reported a fall were either barefoot, wearing socks without ...
... LOS ANGELES (June 23, 2010) Migraine sufferers ... greater risk of cardiovascular (CV) disease including stroke and ... at the American Headache Society,s 52nd Annual Scientific ... multi-center, cross-sectional study of more than 1,300 headache clinic ...
Cached Medicine News:Health News:Tool manipulation is represented similarly in the brains of the blind and the sighted 2Health News:Polio outbreak in Tajikistan is cause for alarm 2Health News:No more peek-a-boo hospital gowns, no more bottoms up 2Health News:Amniotic membrane used to repair human articular cartilage 2Health News:Institute for Aging Research study says going barefoot in home may contribute to elderly falls 2Health News:Institute for Aging Research study says going barefoot in home may contribute to elderly falls 3Health News:Migraine sufferers who experienced childhood abuse have greater risk of cardiovascular disease 2
... A common sight in laboratories everywhere, ... rugged, dependable centrifuge standards for decades ... The Model K's simple, classic design ... it a standard for centrifuge performance, ...
... Hybridizer hybridization ovens are designed to create the ... Temperature control (ambient to 99.9C) , Variable ... saturation of samples, whether it be for washing ... displays the current temperature inside the chamber, ,is ...
... is the first automated system for the ... thermal and wash cycles for the hybridization ... A 12-position GeneMachines HybStation allows for ... individual ports allow for independent probe introduction ...
Maxi XL Hybridization Oven for Extra Large bottles. 6 bottle (70 mm) rotisserie + shaker tray available for simultaneous use. Includes linear and orbital shaker trays, 4 extra large bottles, pack o...
Medicine Products: