Navigation Links
Nventa Announces Presentation of Positive HspE7 Data from,NCI-Sponsored Clinical Trial in Cervical Dysplasia

dging trial by mid-2007, pending submission of the final sections of an amendment to our original HspE7 Investigational New Drug application to the U.S. Food and Drug Administration."

Trial Design

------------

The trial presented today was a single-arm, open-label, Phase II study to establish the response rate and safety profile of HspE7 in women with biopsy-proven CIN III. The secondary aim was to correlate clinical responses to HspE7 vaccination in women infected with HPV 16 compared to women infected with other HPV types. Responses to HspE7 were determined by pathology of post-vaccination Loop Electrosurgical Excision Procedure (LEEP) specimens. (LEEP is a standard procedure for patients with high grade dysplasia to remove the affected areas.) A pathologic complete response (pCR) was defined as a specimen negative for CIN. A partial response (PR) was determined by a 50 percent or more reduction of lesion size post-vaccination.

Trial Results

-------------

71 patients were registered, of whom 62 were eligible after screening. 58 patients completed the trial and were evaluable (31 in cohort 1, 27 in cohort 2). There were no significant HPV type differences between the 2 cohorts so responses were combined for analysis. Of the 58 patients, 13 (22.5 percent) had a pCR; 32 (55 percent) had a PR and 11 (19 percent) had stable disease. Two (3.5 percent) patients in cohort 2 had microinvasive disease and were defined as progressive disease. The overall response rate was 45/58 (78 percent). 33/58 (57 percent) of the patients were infected with HPV 16 prior to vaccination or in subsequent visits. There was no significant difference in regression in women infected with HPV 16 compared to those without HPV 16 infection (88 percent vs. 70 percent; p=0.12). Similar responses were seen in patients infected with multiple HPV types compared to those infected with one type (p=0.20). HspE7 showed efficacy in patients infected with HPV types o
'"/>




Page: 1 2 3 4 5 6

Related medicine technology :

1. Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
2. Neose Announces Presentation of Positive Preclinical Data on GlycoPEGylated Factor VIIa at the XXI Congress of the International Society on Thrombosis and Haemostasis
3. Biofrontera AG Announces Clinical Study Confirms Excellent Efficacy of BF-200 ALA In Actinic Keratosis
4. YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial
5. BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
6. Portola Pharmaceuticals Announces Positive Data from a Phase II Study of its Factor Xa Inhibitor at the XXI Congress of the International Society on Thrombosis and Haemostasis
7. Manhattan Pharmaceuticals Announces Results of Phase 2a Studies for Oral Oleoyl-estrone
8. AVI BioPharma Partner Cook Medical Announces Completion of Patient Enrollment for APPRAISAL Phase II Clinical Trial for Treatment of Cardiovascular Disease
9. Protox Announces Positive Clinical Data from Prostate Cancer Study
10. Inspire Announces Webcast of Presentation at C.E. Unterberg, Towbin Emerging Growth Opportunities Conference
11. NexMed Announces Completion of Patient Enrollment in Two Pivotal Phase 3 Studies for Anti-Fungal Product
Post Your Comments:
(Date:1/15/2014)... MultiCell Technologies, Inc. (OTC Bulletin Board: MCET.OB ... composition of matter, biological targets, mechanism of action, methods ... This patent application describes a novel class ... which interfere with the basic homeostatic cellular processes in ...
(Date:1/15/2014)... Jan. 15, 2014  According to Millennium Research Group ... intelligence, the United States ... markets will expand moderately through 2022, with embolization ... particular, increasing interest in drug-eluting beads (DEBs) and ...
(Date:1/15/2014)... 2014  Valeant Pharmaceuticals International, Inc. (NYSE: VRX ... period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976 ... by its indirect wholly-owned subsidiary, Sapphire Subsidiary Corp. ("Purchaser"), ... of Solta Medical, Inc. (NASDAQ: SLTM ) ...
Breaking Medicine Technology:MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 2MultiCell Technologies Files Patent Application Covering New Class of RNA Therapeutics 3US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 2US and European Transcatheter Embolization and Occlusion Device Market to Surpass $1.6 Billion by 2022 3Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3
(Date:7/9/2014)... active in almost all types of cancer sends the ... help fuel a tumour,s uncontrolled growth, new research suggests. ... identified a molecular trigger responsible for ratcheting up activity ... that makes the building blocks cancer cells need to ... pathway, called SREBP, controls the flow of messages to ...
(Date:7/9/2014)... most common type of lung cancer, researchers have uncovered ... in forming tumors. The new knowledge may expand treatments ... changes already are available or are in clinical trials. ... from The Cancer Genome Atlas (TCGA), including researchers at ... Medical School and other institutions, studied tumors from 230 ...
(Date:7/9/2014)... a relatively optimistic picture of women,s chances of surviving ... the chest wall or skin, but not beyond. ... size and whether they have involved lymph nodes, are ... advanced" tumors, suggesting that they are a relatively serious ... breast cancers of this and other types account for ...
(Date:7/9/2014)... drug users in Russia might contribute to HIV ... conducted by researchers from Boston University Schools of ... Petersburg Pavlov State University, sought to discover the ... of a cohort of HIV-positive people with lifetime ... arrested by police were more likely to share ...
(Date:7/9/2014)... Although feelings are personal and subjective, the ... that objectively represents emotions across different senses, situations ... Cornell University neuroscientist Adam Anderson. , "We discovered ... orbitofrontal cortex, an area of the brain associated ... which captures an individual,s subjective feeling," says Anderson, ...
Breaking Medicine News(10 mins):Health News:Signal may send cancer's cellular factories into overdrive 2Health News:Lung cancer study hints at new treatments 2Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 2Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 3Health News:BU researchers relate arrests with HIV risk environment 2Health News:Study cracks how the brain processes emotions 2
... that post-menopausal women who gain weight in adulthood are at ... irrespective of whether they are on hormone replacement therapy (HRT). ... have explored the relationship between breast cancer types and weight ... publication of the American Cancer Society. ,The effect ...
... officials in Tripura have announced that, they are taking preventive ... malaria from the past three months//. ,A ... also scheduled to visit Tripura to assess the situation and ... resistance. He also stated that almost 200 teams, consisting ...
... many youth under a spell. Recent figures have revealed the ... an increase of 400%, ever since the labour has come ... specialized services to remedy this menace, among children. Neil McKeganey, ... said: "These figures are shocking and they underline the reason ...
... is witness to an International Aids Candlelight Memorial which is ... very much a domestic problem and disassociating from it is ... estimated that nearly 2700 New Zealanders are suffering HIV. The ... people who had died of AIDS. But this time, it ...
... to end the medicos stir, the government has issued ... senior faculty members// who are supporting them. ... vacate hostels if they fail to return to work," ... step was taken after government issued advertisements for recruiting ...
... havoc with health, a new study has found that more ... suffers// from metabolic syndrome, a condition which predisposes people to ... per cent of the people in the age group of ... signified by combination of factors like high blood pressure, high ...
Cached Medicine News:Health News:Obese Women At Increased Risk Of Developing Breast Cancer 2Health News:Striking Students Asked to Vacate Hostels 2
... the heart of the Espion2 Electrophysiology system. ... aluminum chassis, real-time DSP, USB control, an ... differential amplifiers. The E2 connects to any ... over standard wi-fi Ethernet. The E2 includes ...
... breakthrough in visual field testing that's so ... FDT, the first visual field instrument that's ... to be used even in pre-test. Affordably ... clinical trials behind it to validate performance. ...
... Automatic Perimeter, a compact version of ... reputation, provides an accurate visual field ... and has function required for visual,field ... visual field very quickly. It ...
... AAA Endoprosthesis is an innovative device designed ... for patients with abdominal aortic aneurysms (AAA). ... bifurcated graft with an outer self-expanding Nitinol ... and material durability. The function of the ...
Medicine Products: