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Novel Mechanism Insights and Additional Data on CombinatoRx Drug,Candidates to Be Presented at Upcoming EULAR Meeting

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Jun 6, 2007 - CombinatoRx, Incorporated (NASDAQ: CRXX), today announced that data from its randomized, blinded, placebo-controlled phase 2 clinical trials of CRx-102 in patients with osteoarthritis (OA) and rheumatoid arthritis (RA) will be featured at the European League against Rheumatism (EULAR) Annual Congress of Rheumatology meeting, June 13-16, 2007 in Barcelona, Spain.

Schedule of Events:

-- Satellite Symposium, Room 111, Thursday, June 14, 2007 8:15-9:45am

"Novel Approaches to Improve Treatment Outcomes in Arthritis"

Co-Chairs: Steven Abramson, MD, Professor, Medicine and Pathology, Hospital for Joint Diseases, New York, NY and Josef Smolen, MD, Professor, Rheumatology, Medical University of Vienna, Vienna, Austria.

-- Poster #THU0051, Thursday, June 14, 2007, 11:45-1:30pm

"Inhibition of Macrophage and Chrondrocyte Inflammatory Mediators by CRx-102, a Novel Synergistic Combination Drug Candidate", Fraser, et.al.

-- Poster #SAT0236, Saturday, June 16, 2007, 10:15-11:45am

"Response and State-Attainment Criteria in Hand OA: Analyses from a Placebo-Controlled Clinical Trial of CRx-102, a Novel Synergistic Combination Therapy", Kvien, et.al.

-- Poster #SAT0049, Saturday, June 16, 2007, 10:15-11:45am

"A Phase 2a Trial to Evaluate CRx-102 for the Treatment of Active Rheumatoid Arthritis", Kirwan, et.al.

Abstracts are currently available online via the EULAR website (www.EULAR.org) and the posters will be available on the CombinatoRx website (www.combinatorx.com) following presentation.

About CRx-102

CRx-102 is an oral synergistic combination drug candidate containing the cardiovascular agent dipyridamole and an unconventionally low dose of the steroid prednisolone. CRx-102 works through a novel mechanism of action in which dipyridamole selectively amplifies prednisolone's anti-inflammatory and
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